Axamon
Axamon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Axamon
ATX code: N07AA
Active ingredient: ipidacrine (ipidacrine)
Producer: Obninsk Chemical-Pharmaceutical Company (Russia), PIK-PHARMA (Russia)
Description and photo update: 2019-16-08
Prices in pharmacies: from 419 rubles.
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Axamon is a cholinesterase inhibitor, an agent for the treatment of disorders of the nervous system.
Release form and composition
Axamon is produced in tablets and in solution for subcutaneous or intramuscular administration.
The active ingredient in all forms of the drug is ipidacrine hydrochloride in the form of a monohydrate. 1 tablet contains 15 mg of active ingredient. Excipients in the tablets are sodium carboxymethyl starch, ludipress and calcium stearate. The solution contains 0.1M hydrochloric acid solution and water for injection.
Pharmacological properties
Pharmacodynamics
Axamon is a reversible cholinesterase inhibitor that blocks membrane potassium channels, directly stimulating impulse conduction in the central nervous system and neuromuscular synapse. Enhances the action of acetylcholine, adrenaline, histamine, oxytocin and serotonin on smooth muscles.
Axamon has the following pharmacological effects:
- improvement and stimulation of impulse conduction in the central nervous system and neuromuscular transmission;
- improvement of conductivity in the peripheral nervous system in case of disorders due to inflammation, trauma, exposure to local anesthetics, potassium chloride, some antibiotics, etc.;
- increased contractility of smooth muscle organs under the influence of agonists of adrenaline, acetylcholine, histamine, oxytocin and serotonin receptors (excluding potassium chloride);
- improvement of memory, inhibition of the progressive development of dementia.
Axamon has no embryotoxic, teratogenic, carcinogenic, immunotoxic and mutagenic effects. Does not affect the endocrine system.
Pharmacokinetics
When taken orally, it is rapidly absorbed from the gastrointestinal tract. The time to reach the maximum plasma concentration is 60 minutes. The connection with plasma proteins is 40–55%. The half-life is about 40 minutes. The active substance is metabolized in the liver. It is excreted through the kidneys (the main route is tubular secretion, 1/3 of the dose is excreted by glomerular filtration) and extrarenally.
When administered intramuscularly and subcutaneously, it is rapidly absorbed. The time to reach the maximum plasma concentration is 25-30 minutes. Communication with plasma proteins - 40-50%. It enters the tissue quickly. The active substance is metabolized in the liver. It is excreted through the kidneys (the main route is tubular secretion, 1/3 of the dose is excreted by glomerular filtration) and extrarenally. With parenteral administration, the half-life of the drug is 2–3 hours. After parenteral administration, 34.8% of the dose is excreted unchanged in the urine.
Indications for use
According to the instructions, Axamon is prescribed for the treatment of:
- Polyneuritis;
- Neuritis;
- Myasthenia gravis and myasthenic syndromes;
- Multiple sclerosis;
- Myelopolyradiculoneuritis;
- Neuropathy;
- Paresis and bulbar paralysis, accompanied by movement disorders;
- Alzheimer's disease;
- Encephalopathy of vascular, traumatic and other origin;
- Circulatory disorders of the brain.
Axamon effectively eliminates functional disorders of the nervous system, such as disorientation, lability, poor concentration, memory impairment. The drug is included in the complex therapy of demyelinating diseases, it is prescribed for traumatic brain injuries.
There are many positive reviews about the use of Axamon for the treatment of children with cerebral dysfunction and learning difficulties. It was also noted that due to the relaxing effect on the muscles, the drug can be used with weakness of labor and intestinal atony.
Contraindications
- Epilepsy;
- Angina pectoris;
- Severe bradycardia;
- Bronchial asthma;
- Extrapyramidal and vestibular disorders;
- Sensitivity to drug components;
- Lactation period;
- Pregnancy.
The drug is contraindicated in children under 18 years of age.
Instructions for the use of Axamon: method and dosage
Axamon is administered intramuscularly, subcutaneously and taken orally.
For lesions of the peripheral nervous system, 20 mg is prescribed 3 times a day.
With myasthenia gravis, myasthenic syndrome, demyelinating lesions of the nervous system, an increased dosage is used: 20-40 mg 4-5 times a day. The maximum allowable daily dosage is 180-200 mg.
For the treatment of Alzheimer's disease and other types of dementia, the dosage is selected individually, on average it is 10-20 mg 2-3 times a day. This takes into account the fact that no more than 200 mg of the drug can be administered per day. The duration of treatment is from 1 to 12 months.
When prescribing the drug in high doses, it is recommended to take it 4-5 times a day with a break of 2-3 hours.
With intestinal atony, 15-20 mg of the drug is prescribed 2-3 times a day for 1-2 weeks.
Side effects
The drug is well tolerated in most cases. In some cases, the use of Axamon causes:
- Nausea;
- Jaundice;
- Diarrhea;
- Vomiting;
- Decreased appetite;
- Strengthening intestinal peristalsis;
- Dizziness;
- Ataxia;
- Rash;
- Itchy skin;
- Chest pain;
- Bradycardia;
- Bronchospasm;
- Decrease in body temperature;
- Increased sweating;
- Weakness;
- Drowsiness;
- Limb tremor;
- Miosis;
- Headache;
- Convulsions.
Overdose
Symptoms: bronchospasm, decreased appetite, increased sweating, lacrimation, nystagmus, pupil constriction, vomiting, increased gastrointestinal motility, spontaneous urination and defecation, jaundice, intracardiac conduction disturbance, anxiety, arrhythmias, decreased blood pressure, anxiety, anxiety, speech disorders, drowsiness, general weakness, ataxia, convulsions, coma.
Treatment: gastric lavage, use of m-anticholinergics (metacin, cyclodol, atropine), symptomatic therapy.
special instructions
During the period of use of Axamon, it is undesirable to consume alcohol, engage in activities that require increased attention and speed of reaction. Also, when using the product, it is recommended to avoid driving vehicles.
Patients with ulcerative lesions of the gastrointestinal tract, thyrotoxicosis, diseases of the cardiovascular system should take the drug only under the supervision of a physician.
The product is available with a prescription.
Application during pregnancy and lactation
When using Axamon, an increase in the tone of the uterus is observed, which can provoke premature birth, therefore it is contraindicated to use it during pregnancy.
There are no data on the action of Axamon during breastfeeding, therefore the drug is contraindicated during this period.
Pediatric use
It is forbidden to use Axamon to treat patients under the age of 18.
Drug interactions
In combination with drugs to suppress the central nervous system, an increase in the sedative effect is possible.
When taken together with other m-cholinomimetic agents and cholinesterase inhibitors, side effects and the action of Axamon are enhanced.
With myasthenia gravis, in cases of joint administration of ipidacrine and other cholinergic drugs, the likelihood of a cholinergic crisis increases.
If β-blockers were used before the start of Axamon therapy, the risk of developing bradycardia increases.
Weakens the inhibitory effect of local anesthetics, potassium chloride, aminoglycosides on the conduction of excitation along peripheral nerves and neuromuscular transmission.
Drinking alcohol increases the side effects of Axamon.
Analogs
Among the analogues of Axamon, drugs can be distinguished: Ipidacrine, Amiridin and Neuromidin.
Terms and conditions of storage
The drug must be stored in a dark and dry place, out of the reach of children, at temperatures up to 25 ° C.
Shelf life of Axamon is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Axamon
Reviews about Axamon indicate that this drug is effective in the treatment of diseases of the peripheral nervous system, myasthenia gravis (ptosis decreases, fatigue of facial muscles and weakness decrease). In the treatment of encephalopathies, polyneuropathies and memory impairments, Axamon is also effective, but in these cases, long-term treatment is required.
The drug is also successfully used as part of the complex therapy of facial nerve neuropathy (there is no nerve degeneration with the formation of facial muscle contractures).
Users note the good tolerance of Axamon: there are practically no serious complications when using it. The most common side effects (heartburn, nausea, dizziness, epigastric pain) depend on the dose. There are isolated reports of insomnia and agitation. When re-administered after discontinuation, the drug was well tolerated.
The price of Axamon in pharmacies
The approximate price for Axamon is: 50 tablets 20 mg - 700 rubles, 10 ampoules 5 mg / ml - 600 rubles, 10 ampoules 15 mg / ml - 1050 rubles.
Axamon: prices in online pharmacies
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Drug name Price Pharmacy |
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Axamon 5 mg / ml solution for intramuscular and subcutaneous administration 1 ml 10 pcs. 419 RUB Buy |
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Axamon solution for intramuscular injection and for subcutaneous injection 5mg / ml 1ml 10 pcs. 659 r Buy |
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Axamon 20 mg tablets 50 pcs. RUB 678 Buy |
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Axamon tablets 20mg 50 pcs. 845 RUB Buy |
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Axamon 15 mg / ml solution for intramuscular and subcutaneous administration 1 ml 10 pcs. RUB 958 Buy |
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Axamon solution for intramuscular injection and for subcutaneous injection 15mg / ml 1ml 10 pcs. 1339 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
