9 months Folic acid
Latin name: Folic acid 9 months
ATX code: B03BB01
Active ingredient: Folic acid (Folic acid)
Producer: Valenta Pharmaceuticals, PJSC (Russia)
Description and photo update: 2018-24-10
Prices in pharmacies: from 80 rubles.
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9 months Folic acid is a drug that replenishes folic acid deficiency.
Release form and composition
Dosage form release 9 months Folic acid - film-coated tablets: yellow, biconvex, round; the core on the fracture is light yellow with splashes (in a cardboard box 3, 6 or 9 blisters of 10 tablets each).
Composition of 1 tablet:
- active ingredient: folic acid - 0.4 mg;
- auxiliary components: lactose monohydrate, magnesium stearate, Kollidon VA-64, colloidal silicon dioxide;
- shell: Opadry II (series 85) [polyvinyl alcohol, talc, macrogol, titanium dioxide (E171), yellow iron oxide (E172), quinoline yellow-based aluminum varnish (E104)].
Pharmacological properties
Pharmacodynamics
Folic acid is a vitamin of group B (B 9, B c), it can be synthesized by the intestinal microflora. It is restored in the body to tetrahydrofolic acid, which is a coenzyme and is necessary for various metabolic processes.
Folic acid is required for the formation of normoblasts and the normal maturation of megaloblasts. Participates in the synthesis of nucleic acids, amino acids (including glycine, methionine), pyrimidines, purines, in the exchange of histidine and choline, and also stimulates erythropoiesis.
Pharmacokinetics
Folic acid is fully and well absorbed in the gastrointestinal tract, mainly in the upper duodenum. It binds to plasma proteins almost completely.
Under the influence of the enzyme dihydrofolate reductase, it is activated in the liver, turning into tetrahydrofolic acid. T max (time to reach maximum concentration) ranges from 30 to 60 minutes. Penetrates the blood-brain and placental barriers into breast milk.
Excretion occurs mainly by the kidneys in the form of metabolites, with a significant excess of the daily dose - in an unchanged form.
It is excreted using hemodialysis.
Indications for use
- folic acid deficiency;
- defects of the neural tube in the fetus in the first trimester of pregnancy (prevention of development).
Contraindications
- cobalamin deficiency;
- malignant neoplasms;
- pernicious anemia;
- childhood;
- individual intolerance to any component of the drug.
Instructions for use 9 months of Folic acid: method and dosage
The drug is taken orally, preferably after meals.
Recommended dosage regimen:
- folic acid deficiency: 1 tablet a day;
- prevention of the development of neural tube defects in the fetus (I trimester of pregnancy): 1-2 tablets per day.
Side effects
- digestive system: anorexia, nausea, bitterness in the mouth, bloating;
- allergic reactions: hyperthermia, itching, skin rash, erythema, bronchospasm.
During a long course, the development of hypovitaminosis B 12 can be observed.
Overdose
Overdose can occur with prolonged use (longer than 1–2 months) of folic acid in doses exceeding 1 mg per day, as well as as a result of combined therapy with vitamin and mineral complexes.
special instructions
In order to prevent hypovitaminosis, a balanced diet is more preferable. Foods rich in folic acid include nuts, fresh liver, green vegetables (carrots, lettuce, tomatoes, spinach), legumes, beets, cheese, cereals, eggs.
For the treatment of B 12 -deficient (pernicious), aplastic and normocytic anemia, as well as anemia refractory to therapy for 9 months, folic acid is not used.
The drug for pernicious anemia improves hematological parameters, but at the same time masks neurological complications. Until pernicious anemia is ruled out, it is not recommended to prescribe the drug in a daily dose of more than 0.1 mg (except for taking by lactating / pregnant women).
It should be taken into account that patients on hemodialysis should be prescribed increased doses of the drug.
During treatment, cholestyramine should be taken 4-6 hours before or 1 hour after taking 9 months of folic acid, antacids - after 2 hours.
It should be borne in mind that drugs with antibacterial action can distort (underestimate) the results of a microbiological assessment of the concentration of folic acid in erythrocytes and plasma. When using the drug in large doses, as well as during long-term therapy, the concentration of vitamin B 12 may decrease.
Application during pregnancy and lactation
The drug is indicated in preparation for pregnancy (1–3 months before the planned pregnancy) and during the first few weeks after conception (I trimester).
Pediatric use
According to the instructions, folic acid is not prescribed for 9 months in childhood.
Drug interactions
Possible interactions:
- oral contraceptives, pain relievers (long-term use), drugs with anticonvulsants (including carbamazepine and phenytoin), estrogens: an increase in the need for folic acid;
- phenytoin: a decrease in its effectiveness (an increase in its dose may be required);
- trimethoprim, methotrexate, triamterene, pyrimethamine: decrease in the effectiveness of folic acid due to inhibition of dihydrofolate reductase (instead of 9 months of folic acid, patients are prescribed calcium folinate);
- cholestyramine, antacids, sulfonamides (including sulfasalazine): decreased absorption of folic acid;
- chloramphenicol, neomycin, polymyxins, tetracyclines: reduced absorption of folic acid.
Analogs
Folic acid analogs for 9 months are: Mamifol, Folacin, Folic acid.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Folic acid 9 months reviews
According to reviews, 9 months Folic acid is an effective drug necessary when planning pregnancy and throughout the first trimester. A convenient dosing regimen is noted. Of the shortcomings, they point to the possibility of developing side effects and high cost compared to analogues.
Price for 9 months Folic acid in pharmacies
The approximate price for 9 months of Folic acid (in a package of 30 tablets) is 103-136 rubles.
9 months Folic acid: prices in online pharmacies
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Drug name Price Pharmacy |
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9 months Folic acid 400 mcg film-coated tablets 30 pcs. RUB 80 Buy |
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9 months folic acid tablets p.o. 0.4mg 30 pcs. 118 RUB Buy |
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9 months Folic acid 400 mcg film-coated tablets 90 pcs. 320 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
