Phenylpiracetam
Phenylpiracetam: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Fonturacetam
ATX code: N06BX
Active ingredient: fonturacetam (Fonturacetam)
Producer: Obninsk Chemical-Pharmaceutical Company, CJSC (Russia)
Description and photo updated: 2020-19-03
Phenylpiracetam is a nootropic drug.
Release form and composition
The drug is produced in the form of tablets: flat-cylindrical, round, from white to white with a yellow tint; in a dosage of 50 mg - with a chamfer, in a dosage of 100 mg - with a chamfer and a risk (10 pcs. in a blister strip, in a cardboard box 1, 2, 3, 4 or 5 packages and instructions for use of Phenylpiracetam).
1 tablet contains:
- active substance: phonylpiracetam - 50 or 100 mg;
- additional components: microcrystalline cellulose, povidone K17, magnesium stearate, sodium carboxymethyl starch.
Pharmacological properties
Pharmacodynamics
Phenylpiracetam is a nootropic agent that has a pronounced antiamnestic effect. The active substance has a direct stimulating effect on the integrative activity of the brain. The drug promotes memory consolidation, improves concentration and mental activity, facilitates the learning process, increases the speed of information transfer between the cerebral hemispheres and the resistance of the brain tissue to toxic effects and hypoxia. The tool normalizes the course of excitation and inhibition processes in the central nervous system (CNS), demonstrates anxiolytic activity and anticonvulsant properties, and improves mood.
The active substance has a positive effect on blood circulation and metabolic processes in the brain, stimulates redox reactions. As a result of increased glucose utilization, it increases the energy potential of the body. In ischemic areas of the brain, it leads to an improvement in regional blood flow. Phenylpiracetam increases the level of serotonin, dopamine and norepinephrine in the brain, does not affect the concentration of gamma-aminobutyric acid (GABA), and does not interact with GABA A and GABA B receptors. Spontaneous bioelectrical activity of the brain is not significantly affected by fonturacetam.
With course use, the drug exhibits anorexigenic activity, has an unexpressed diuretic effect. Does not affect respiration and cardiovascular system (CVS). To a moderate extent, it affects motor reactions, enhances physical performance.
The psychostimulating effect of the drug dominates in the ideational sphere, its moderate psychostimulating effect is combined with anxiolytic activity. Phenylpiracetam improves mood, by increasing the pain threshold it provides a certain analgesic effect.
Promotes an increase in the body's resistance to stress against the background of intense physical and psycho-emotional stress, excessive fatigue, at low temperatures, immobilization, hypokinesia. During treatment with phonylpiracetam, an improvement in vision is recorded, manifested in an increase in acuity, brightness and visual fields. The active substance improves the blood supply to the lower extremities. It has immunostimulating properties, as evidenced by the increased production of antibodies with the introduction of antigen, but at the same time does not cause the development of immediate hypersensitivity and does not lead to a change in the allergic inflammatory reaction of the skin caused by the introduction of a foreign protein.
In the case of course use of Phenylpiracetam, tolerance, drug dependence, withdrawal syndrome do not develop. The effect of the agent is noted already with the introduction of a single dose, which is of great importance when used in extreme conditions.
No carcinogenic, teratogenic, mutagenic and embryotoxic properties were found in the agent, it has low toxicity, in an acute experiment its lethal dose is 800 mg / kg.
Pharmacokinetics
The drug is quickly absorbed, penetrates into various tissues and organs, easily overcomes the blood-brain barrier. After oral administration, the absolute bioavailability of fonturacetam is 100%, the maximum concentration (C max) in the blood is observed after 1 hour, the half-life (T 1/2) is 3-5 hours.
In the body, the agent is not metabolized. In unchanged form, it is eliminated in the urine on average 40% of the drug, with bile and then - 60%.
Indications for use
- lesions of the central nervous system of various origins, mainly associated with vascular pathologies and impaired cerebral metabolism, intoxication (including with manifestations of chronic cerebrovascular insufficiency and post-traumatic conditions), accompanied by a decrease in intellectual-mnestic functions and motor activity;
- psychoorganic syndromes, the symptoms of which include intellectual-mnestic disorders and apathic-abulic phenomena; sluggish states in schizophrenia;
- violations of the learning process;
- neurotic conditions characterized by increased exhaustion, lethargy, weakening of psychomotor activity, memory impairment, impaired attention;
- convulsive conditions;
- alimentary-constitutional (primary) obesity;
- hypoxia (prevention);
- chronic alcoholism (to reduce the severity of the phenomena of intellectual-mnestic disorders, asthenia);
- inversion of the “sleep - wakefulness” cycle, correction of the daily biorhythm.
Phenylpiracetam is also recommended for use in order to correct the functional state against the background of extreme conditions of professional activity to prevent fatigue and to enhance mental and physical performance, in stressful situations in order to increase the body's stability.
Contraindications
Absolute:
- age up to 18 years;
- pregnancy;
- breast-feeding;
- hypersensitivity to any component of Phenylpiracetam tablets.
Relative (it is recommended to carry out drug therapy with extreme caution):
- organic lesions of the liver and kidneys in severe form;
- severe atherosclerosis;
- severe course of arterial hypertension;
- a history of panic attacks, acute psychotic conditions, accompanied by psychomotor agitation (due to the increased risk of exacerbation of panic, anxiety, hallucinations and delirium);
- predisposition to allergic reactions to nootropic drugs from the pyrrolidone group.
Phenylpiracetam, instructions for use: method and dosage
Phenylpiracetam tablets should be taken orally immediately after meals.
The dose and duration of therapy should be determined by the attending physician. Doses of the drug are determined taking into account the characteristics of the patient's condition. A single dose can be 100-250 mg (on average - 150 mg), a daily dose - 200-300 mg (on average - 250 mg). The maximum allowable daily dose should not exceed 750 mg.
It is recommended to take a daily dose of less than 100 mg once a day (in the morning), over 100 mg - divided into 2 doses. The course of treatment can vary from 14 to 90 days, the average duration of therapy is 30 days. If necessary, a second course is possible 1 month after the end of therapy.
In the treatment of alimentary-constitutional obesity, as well as in order to enhance performance, Phenylpiracetam is recommended to be taken 1 time per day (in the morning) at 100-200 mg. In the treatment of primary obesity, the duration of admission is 30-60 days, to improve performance - 14 days (for athletes - 3 days).
Taking pills later than 15 hours is not recommended.
Side effects
Against the background of treatment with Phenylpiracetam, insomnia may develop (mainly when using the drug after 15 hours). Sometimes in the first 3 days of the course, the appearance of such undesirable effects as a feeling of warmth, hyperemia of the skin, increased blood pressure, psychomotor agitation can be observed.
Overdose
There are no reports of overdose cases of Phenylpiracetam. If an overdose is suspected, symptomatic treatment is performed.
special instructions
In patients with excessive psychoemotional exhaustion against the background of fatigue, stress, chronic insomnia on the first day of treatment after a single dose of Phenylpiracetam, there may be a sharp need for sleep. Such patients are advised to begin the course of therapy on non-working days on an outpatient basis.
Influence on the ability to drive vehicles and complex mechanisms
In view of the existing risk of drowsiness, especially in the first days of taking the drug, you must be careful when driving vehicles and controlling other complex moving mechanisms.
Application during pregnancy and lactation
Pregnant and breastfeeding women should not be prescribed Phenylpiracetam, since there are no data from clinical studies in this category of patients.
Pediatric use
Nootropic drug is not used in pediatric practice due to the lack of information confirming the safety and effectiveness of its use in children and adolescents.
With impaired renal function
In severe organic kidney damage, Phenylpiracetam should be used with caution.
For violations of liver function
In severe organic liver damage, drug treatment should be carried out with caution.
Drug interactions
- drugs that stimulate the central nervous system, antidepressants, other nootropic drugs: their therapeutic effect is potentiated;
- hexobarbital, ethanol: the severity of the hypnotic effect of these substances is weakened;
- antipsychotics: phonylpiracetam refers to the pronounced antagonists of the cataleptic action of these funds.
Analogs
The analogues of Phenylpiracetam are Slim Storey prof, Phenotropil, etc.
Terms and conditions of storage
Store in a place protected from light at a temperature not exceeding 30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Phenylpiracetam
Rare reviews of Phenylpiracetam are mostly positive. Patients consider the drug to be a good nootropic agent demonstrating a sufficiently mild prolonged effect to achieve the required clinical result.
However, sometimes there are complaints about the appearance of adverse reactions during therapy, especially drowsiness / insomnia. Some patients report too weak effect of Phenylpiracetam.
Price for Phenylpiracetam in pharmacies
The reliable price of Phenylpiracetam is unknown, since at the moment there is no nootropic drug in the pharmacy network.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
