Phlebof
Phlebof: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Phlebopha
ATX code: C05CA03
Active ingredient: diosmin (diosmin)
Manufacturer: Ozone, LLC (Russia)
Description and photo update: 2018-25-10
Prices in pharmacies: from 202 rubles.
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Phlebofa is an angioprotective agent that has a venotonic effect.
Release form and composition
Phlebofu is produced in the form of tablets: biconvex, oblong, on one side with a risk, from gray-brown to gray-yellow color with possible inclusions of lighter and darker shades (10 pieces in a blister strip, in a cardboard box 1-10 packs; 10, 20, 30, 40, 50, 60 or 100 pcs. In a polymer can, in a cardboard bundle 1 can; it is allowed to complete 2 or 3 cardboard packs in a cardboard package).
1 tablet contains:
- active substance: diosmin - 0.6 g (in terms of the anhydrous substance);
- additional components: sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate, gelatin.
Pharmacological properties
Pharmacodynamics
Diosmin is a benzopyrone derivative; belongs to the group of bioflavonoids, has a phlebotonic and venoprotective effect, reduces the permeability of the vascular wall. The substance helps to reduce the extensibility and increase the tone of the veins, to reduce venous stasis in the lower extremities. The venotonic effect of the drug is dose-dependent, its mechanism is not fully understood. It is assumed that the active substance of Phlebofa blocks the activity of catechol-O-methyltransferase, leading to the breakdown of norepinephrine, which increases venous tone. This hypothesis was confirmed by experimental studies under ex vivo conditions, during which diosmin increased the vasoconstrictor effect of serotonin, adrenaline, and norepinephrine on separated fragments of the great saphenous vein and superficial veins of the forearm. Also, due to the effect of the substance, a decrease in the serum concentration of enzymes that regulate the metabolism of mucopolysaccharides in the venous wall was noted.
According to the data of clinical studies, diosmin helps to reduce the capacity of the venous bed and the volume of venous stasis (according to the results of occlusive plethysmography), to reduce the average pressure in the superficial and deep veins of the legs (according to the results of Doppler ultrasound) and to increase the systolic and diastolic blood pressure (BP) against the background of postoperative orthostatic hypotension. By increasing the frequency of contraction and tone of the lymphatic capillaries, increasing their functional density and reducing lymphatic pressure, the drug enhances lymphatic drainage.
Due to the effect of diosmin, the processes of blood microcirculation are improved - the resistance of the capillaries increases (it has a dose-dependent nature) and their permeability decreases. The substance helps to reduce the adhesion of leukocytes to the venous wall and their movement into paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue. Possessing anti-inflammatory effect, Phlebofa inhibits the production of prostaglandins and thromboxane and the production of free radicals.
Pharmacokinetics
After taking Phlebof's tablets, diosmin is rapidly absorbed from the gastrointestinal tract (GIT) and is detected in the blood plasma 2 hours after administration. Oral bioavailability of the substance is about 40-57.9%. In the process of metabolic transformation of a part of the drug with the participation of cecum bacteria, hippuric and benzoic acids are formed. The maximum concentration of the substance in the plasma is observed 5 hours after ingestion. The accumulation of diosmin occurs in all the walls of the saphenous veins of the lower extremities and vena cava, to a lesser extent in the lungs, liver, kidneys and other tissues.
The volume of distribution is 62.1 liters, the maximum value of the selective accumulation of diosmin and / or its metabolites is noted in the vein wall 9 hours after administration and remains for 96 hours. The agent is rapidly biotransformed in the liver to form the main metabolite, hydroxyphenylpropionic acid. Diosmin metabolites are excreted mainly by the kidneys in the form of conjugates with glucuronic acid. 79% of the taken substance is excreted by the kidneys, 11% by the intestines, 2.4% by the bile.
Phlebofa is characterized by enterohepatic circulation. After ingestion of radioactively labeled diosmin, about 86% is excreted by the intestines and kidneys within 48 hours.
Indications for use
- varicose veins of the lower extremities (to eliminate symptoms);
- chronic form of lymphovenous insufficiency of the lower extremities (to eliminate symptoms);
- acute hemorrhoids (in combination therapy to relieve symptoms);
- disorders of microcirculation processes (for example, in the case of idiopathic edema).
Contraindications
- age up to 18 years;
- I trimester of pregnancy;
- lactation period;
- hypersensitivity to the constituents of the product.
Instructions for use of Phlebofe: method and dosage
Phlebof tablets are taken orally.
The recommended dosage regimen, taking into account the indications:
- varicose veins of the lower extremities: take on an empty stomach in the morning, 0.6 g (1 tablet), the course is on average 2 months;
- chronic lymphovenous insufficiency: take 0.6 g on an empty stomach in the morning, average course - 2 months; in severe forms of the disease (convulsions, pain, swelling, etc.), it is possible to prescribe a longer course, but the total duration of continuous therapy should not be more than 4 months, repeated courses are allowed at intervals of 2-3 months; when treating a disease in the II and III trimesters of pregnancy, the drug is taken once a day at a dose of 0.6 g, the duration of admission is no more than 1 month, therapy must be completed 2-3 weeks before childbirth;
- exacerbation of hemorrhoids: taken with meals, daily dose - 1.2-1.8 g (2-3 tablets), course - 7 days, further, if necessary, it is possible to take 0.6 g once a day (1 tablet) for 1–2 months;
- microcirculation disorders: take 0.6 g on an empty stomach in the morning, course - 1-2 months.
In case of missing one or more receptions of Phlebofa, treatment should be continued as usual at the recommended dosages.
Side effects
- central nervous system: rarely - dizziness, malaise, headache;
- Gastrointestinal tract: often - vomiting, heartburn, nausea, constipation, diarrhea, dyspeptic disorders; infrequently - colitis;
- allergic reactions: rarely - urticaria; with an unknown frequency - isolated edema of the lips, eyelids, face; extremely rare cases - angioedema;
- skin and subcutaneous fatty tissue: rarely - itching, skin rashes.
Overdose
Overdose cases have not been established. Due to the wide therapeutic range of diosmin, the probability of intoxication with its overdose is insignificant. There is no specific antidote.
special instructions
If the combination therapy of acute hemorrhoids fails to achieve a quick clinical effect, it is required to consult a proctologist and, if necessary, after an additional examination, adjust the treatment.
In case of impaired venous circulation, in order to achieve the maximum effect from taking Phlebofe, it is desirable during the period of therapy to reduce excess body weight as much as possible and avoid prolonged standing. In some cases, wearing compression hosiery may be recommended to improve blood circulation.
If, against the background of taking Phlebofa, there is no decrease in the severity of the symptoms of the disease or an aggravation of their manifestations is noted, you should consult a doctor.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Phlebofa does not have a negative effect on the patient's ability to drive vehicles and various mechanisms.
Application during pregnancy and lactation
The experience of using Phlebofa during pregnancy is limited. There are no reports of any harmful effects of the use of diosmin in pregnant women in clinical practice. When conducting experimental studies, the teratogenic effect of the drug on the development of the fetus was not revealed. However, for safety reasons, taking the drug in the first trimester of pregnancy is contraindicated.
If it is necessary to use the drug in the II and III trimesters of pregnancy, a preliminary consultation with a specialist is required.
For breastfeeding women, taking Phlebofe is contraindicated, since there is no information about its penetration into breast milk.
Pediatric use
It is contraindicated for patients under 18 years of age to take the drug, since studies on its use in children and adolescents have not been conducted.
Drug interactions
There are no data on clinically significant interactions of diosmin with other medicinal substances / preparations.
Analogs
The analogues of Phlebofa are Vasoket, Diosmin, Venolek, Phlebodia 600.
Terms and conditions of storage
Store in a place protected from light and out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Phlebof
Reviews about Phlebof are mostly positive. Patients who received the drug note its effectiveness in the treatment of varicose veins and exacerbation of hemorrhoids. According to reviews, the remedy helps to reduce venous stasis, increase the tone of veins and capillaries, relieve swelling, pain and heaviness in the legs. Patients note a convenient scheme for taking the drug, and the fact that its cost is lower than similar in effect to imported drugs. This is of great importance when undergoing a planned course of therapy.
The disadvantages of the drug include the development of such undesirable reactions as weakness, nausea, heartburn, pain in the epigastric region, diarrhea.
The price of Phlebofu in pharmacies
The price of Phlebofu can be approximately: 600 mg tablets (30 pcs. In a package) - from 880 to 930 rubles.
Phlebofa: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Phlebofa cream-gel cream-gel 50 ml 1 pc. 202 RUB Buy |
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Phlebofa 600 mg tablets 30 pcs. RUB 500 Buy |
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Phlebofa 600mg tablets 30 pcs. 740 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
