Phenazalgin
Fenazalgin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Phenazalgin
ATX code: G04BX06
Active ingredient: phenazopyridine (Phenazopyridine)
Producer: Obninsk Chemical-Pharmaceutical Company, CJSC (Russia)
Description and photo update: 2020-05-03
Prices in pharmacies: from 446 rubles.
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Fenazalgin is a local analgesic drug used in urology.
Release form and composition
The drug is produced in the form of film-coated tablets: brown, biconvex, round; the core in cross section is brown with white blotches, reddening in air (6, 7 or 10 pieces in a blister, in a cardboard box 1, 2, 3, 4 or 5 contour packs and instructions for use of Fenazalgin).
1 tablet contains:
- active substance: phenazopyridine hydrochloride - 100 mg;
- additional components: microcrystalline cellulose - 115.5 mg, sodium carboxymethyl starch - 26 mg, talc - 3.75 mg, colloidal silicon dioxide - 2.5 mg, magnesium stearate - 2.25 mg;
- film shell: hypromellose 6 - 3.9 mg, titanium dioxide - 1.3 mg, polydextrose - 1.5 mg, talc - 1.288 mg, macrogol 3350 - 0.6 mg; dyes - iron oxides: yellow - 0.763 mg, red - 0.37 mg and black - 0.279 mg.
Pharmacological properties
Pharmacodynamics
The active substance is excreted in the urine and has a local analgesic effect on the mucous membrane of the lower urinary tract. Thanks to this effect, the severity of dysuric phenomena, such as frequent urination, burning sensation, and pain, is reduced. The exact mechanism of action of Phenazalgin has not been established.
Pharmacokinetics
The pharmacokinetic properties of the drug have not been thoroughly studied. The active substance and its metabolites are intensively excreted by the kidneys from the body. When phenazopyridine is used in a daily dose of 600 mg, 90% of the drug is excreted within 24 hours, while in unchanged form - 41%, and in the form of a metabolite - 49%.
Indications for use
Phenazalgin is recommended for the symptomatic treatment of dysuria (including burning, pain, frequent urination) caused by irritation of the mucous membrane of the lower urinary tract as a result of trauma, infections, surgery, endoscopic procedures, the use of a catheter or probe.
Contraindications
Absolute:
- renal failure;
- functional disorders of the liver;
- anemia and methemoglobinemia;
- age up to 18 years;
- lactation period;
- hypersensitivity to any component of Phenazalgin.
Relative (use the drug in the presence of the following diseases / conditions should be under medical supervision):
- heart failure;
- deficiency of glucose-6-phosphate dehydrogenase;
- neuromuscular diseases;
- age over 65;
- pregnancy.
Phenazalgin, instructions for use: method and dosage
Phenazalgin tablets should be taken orally after meals with a full glass of water. They must be swallowed whole, without breaking or chewing.
It is recommended to take the drug 3 times a day, 200 mg (2 tablets). The course of treatment should not exceed two days, including when combined with antimicrobial agents.
If you accidentally miss the next dose, you should take it as soon as possible. Do not double the dose to compensate for the missed dose.
Side effects
- nervous system: rarely (frequency of occurrence from 1/10 000 to 1/1000) - dizziness, headache, aseptic meningitis;
- immune system: rarely - itching, skin rash, fever and other hypersensitivity reactions; extremely rare (less than 1/10 000) - bronchospasm;
- kidneys and urinary tract: uronephrolithiasis, acute nephrotoxicity (caused by overdose);
- digestive system: rarely - vomiting, nausea, diarrhea; extremely rare - jaundice, acute hepatotoxicity (due to overdose);
- blood and lymphatic system: sulfhemoglobinemia, methemoglobinemia, hemolytic anemia (against the background of glucose-6-phosphate dehydrogenase deficiency), pancytopenia, neutropenia, leukopenia;
- allergic reactions: allergic hepatitis, anaphylactoid reaction;
- others: rarely - staining of urine in a dark orange or reddish color; staining of feces in an orange-red color; extremely rarely (with prolonged use) - a change in the pigmentation of the sclera and skin with yellowish staining, yellowing of the nails; eye irritation, blurred vision, reversible loss of color vision, ear pain, swelling of the face, upper and lower extremities.
Overdose
Exceeding the recommended dose of Phenazalgin, especially in patients with reduced renal function and the elderly, may cause an increase in its serum concentration in the blood and the occurrence of toxic reactions. Overdose symptoms may include methemoglobinemia (mainly in the presence of glucose-6-phosphate dehydrogenase deficiency), nephro- and hepatotoxic effects, increased severity of other side effects.
In this condition, Phenazalgin therapy should be canceled, vomiting and other measures should be taken to promote the elimination of phenazopyridine from the body, symptomatic treatment is also recommended. In order to eliminate methemoglobinemia and the symptoms caused by it, intravenous administration of a solution of methylene blue 1% at a dose of 1–2 mg / kg is prescribed.
special instructions
Reception of Phenazalgin in order to relieve symptoms of dysuria as a result of infection should not delay the timely diagnosis and pathogenetic treatment. The drug is recommended for the elimination of pain and other manifestations of dysuria and cannot be used as a drug for specific antimicrobial therapy.
In individuals with deficiency of glucose-6-phosphate dehydrogenase, the use of Phenazalgin can cause hemolysis of erythrocytes and the development of methemoglobinemia.
Staining during treatment of the sclera and skin in a yellowish color may indicate the accumulation of phenazopyridine due to its overdose or impaired renal function, or the use of the agent for more than 2 days, which requires discontinuation of its intake.
The duration of therapy should not exceed 2 days. In the course of toxicological studies, it was found that one of the phenazopyridine metabolites, namely 2,3,6-triaminopyridine, is capable of damaging cardiomyocytes and cells of striated muscle tissue. As a result, special care is required when prescribing Fenazalgin to patients with neuromuscular diseases and lesions of the cardiovascular system.
Phenazopyridine can cause staining of contact lenses, therefore, when using the drug, you should stop wearing them.
During the period of treatment with Phenazalgin, changes in the results of urine tests carried out by photometric, colorimetric and fluorimetric methods (establishing the concentration of porphyrins, ketone bodies, urobilinogen) may be noted.
In case of development of negative phenomena, you should stop taking the drug and urgently consult a doctor.
Influence on the ability to drive vehicles and complex mechanisms
Patients driving motor vehicles and other complex moving mechanisms, if an adverse reaction in the form of dizziness occurs during treatment, should not perform such activities.
Application during pregnancy and lactation
Data confirming the presence of a teratogenic effect in Phenazalgin, in the experiment when it was used in combination with sulfacitin in rats at a daily dose of up to 110 mg / kg and in rabbits at a daily dose of up to 39 mg / kg, were not obtained. However, due to the limited clinical data on the use of phenazopyridine in pregnant women, as well as its ability to pass through the placenta, the drug during gestation should be used only under strict indications, if the expected benefit to the woman outweighs the possible threat to the fetus.
It is not established whether phenazopyridine is excreted in breast milk, therefore, during the period of breastfeeding, treatment with Phenazalgin is contraindicated. If you need to take the drug during lactation, you should stop breastfeeding.
Pediatric use
For persons under 18 years of age, drug therapy is contraindicated due to the lack of information on its effectiveness and safety in patients of this age group.
With impaired renal function
Patients with renal insufficiency are contraindicated in taking Phenazalgin tablets. The risk of age-related decline in kidney function must also be considered.
For violations of liver function
Phenazalgin is contraindicated in patients with any liver dysfunction.
Use in the elderly
Persons over 65 years of age Fenazalgin should be taken with caution due to lack of experience in use.
Drug interactions
With the combined use of Phenazalgin with ciprofloxacin, an increase in the bioavailability of the latter is possible.
There is no information on the interaction of phenazopyridine with other drugs.
If necessary, Phenazalgin can be taken in combination with antimicrobial drugs.
Analogs
There are no data on analogues of Phenazalgin.
Terms and conditions of storage
Store out of the reach of children, protected from light, at a temperature not exceeding 30 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Phenazalgin
The reviews about Phenazalgin found on specialized sites are usually positive. Patients note that the analgesic urological drug, exerting a narrowly targeted effect on the urinary tract with dysuria, quickly relieves pain, effectively relieves burning sensation, and reduces the frequency of urge to urinate. However, since phenazopyridine only weakens the severity of the symptoms of the disease, but does not eliminate the causes of its development, for successful treatment, the drug should be used in combination with antibiotics prescribed by the doctor.
The disadvantages of the drug are usually attributed to its high cost and staining of urine during treatment in a bright orange color.
Price for Phenazalgin in pharmacies
The price of Phenazalgin in the form of film-coated tablets can be 480-500 rubles per package containing 10 pcs. 100 mg.
Fenazalgin: prices in online pharmacies
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Drug name Price Pharmacy |
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Phenazalgin 100 mg film-coated tablets 10 pcs. 446 r Buy |
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Phenazalgin tablets p.p. 100mg 12pcs RUB 488 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
