Aminoven Infant
Aminoven Infant: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. With impaired renal function
- 10. For violations of liver function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Aminoven Infant
ATX code: B05BA01
Active ingredient: amino acids for parenteral nutrition (Aminoacids for parenteral nutrition)
Producer: Fresenius Kabi Deutschland, GmbH (Fresenius Kabi Austria, GmbH) (Austria)
Description and photo update: 2019-10-07
Prices in pharmacies: from 4299 rubles.
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Aminoven Infant is a solution of amino acids for parenteral nutrition.
Release form and composition
Dosage form - solution for infusion: transparent or somewhat opalescent, from light yellow to colorless (in a cardboard box there are 10 bottles of 100 or 250 ml each with / without plastic holders and instructions for use of Aminovena Infant).
Active substances in 1 liter of solution (6/10% solution):
- L-isoleucine - 4.8 / 8 g;
- L-phenylalanine 2.25 / 3.75 g;
- L-tryptophan 1.206 / 2.01 g;
- L-arginine - 4.5 / 7.5 g;
- L-valine - 5.4 / 9 g;
- L-leucine - 7.8 / 13 g;
- L-methionine 1.872 / 3.12 g;
- L-threonine 2.64 / 4.4 g;
- L-histidine 2.856 / 4.76 g;
- L-alanine 5.58 / 9.3 g;
- L-proline 5.826 / 9.71 g;
- L-serine 4.602 / 7.67 g;
- L-tyrosine 2.52 / 4.2 g (N-acetyl-L-tyrosine 3.106 / 5.176 g);
- L-cysteine - 0.312 / 0.52 g (N-acetyl-L-cysteine - 0.42 / 0.7 g);
- L-lysine 5.11 / 8.51 g (L-lysine monoacetate 7.2 / 12 g);
- L-malic acid - 1.572 / 2.62 g;
- glycine - 2.49 / 4.15 g;
- taurine - 0.24 / 0.4 g
Auxiliary component: water for injection - up to 1 liter.
Solution characteristics (6/10%):
- total amino acid content - 60/100 g;
- total nitrogen content - 9 / 14.9 g;
- theoretical osmolarity - 531/885 mOsm / l;
- titratable acidity - 27–40 / 27–40 mmol NaOH / l;
- pH - 5.5-6.0 / 5.5-6.0.
Pharmacological properties
Pharmacodynamics
The amino acids that make up Aminovena Infant are among the physiological components. After parenteral administration of the solution, they are included in the pool of free amino acids of the body and take part in all metabolic processes, including used for protein biosynthesis.
Pharmacokinetics
When administered intravenously, the bioavailability of Aminovena Infant is 100%. After inclusion in the total pool of free amino acids of the body, distribution occurs in the interstitial fluid and the intercellular space of tissues and organs.
The concentration of free amino acids in the cytoplasm of cells and blood plasma is regulated within narrow limits and depends on several factors, including age, nutritional status and general condition of the patient. Aminoven Infant, when administered correctly (at a constant rate and slowly), does not lead to an imbalance of amino acids. In patients with severely impaired liver and kidney function, there is a dysregulation of the amino acid balance. In such cases, special prescriptions of amino acid solutions should be used for parenteral nutrition.
Only a small part of amino acids is eliminated by the kidneys. The value of the half-life of a drug from plasma is largely determined by age.
Indications for use
Aminoven Infant is prescribed for partial parenteral nutrition of newborns, premature infants and young children.
Complete parenteral nutrition is provided with simultaneous use with fat emulsions, carbohydrate solutions, as well as preparations of vitamins, trace elements and electrolytes.
Contraindications
Absolute:
- overhydration;
- metabolic acidosis;
- metabolic disorders of amino acids;
- hypokalemia.
Relative (the use of Aminovena Infant requires individual dosing):
- liver failure;
- renal failure.
Aminoven Infant, instructions for use: method and dosage
The drug is intended for long-term drip intravenous administration. The duration of use is determined by the need for parenteral nutrition.
Aminoven Infant 6%
The drug is injected into the central or peripheral veins.
Maximum daily dose:
- up to 1 year: 1.5-2.5 g / kg, or 25-40 ml / kg;
- 2-5 years: 1.5 g / kg, or 25 ml / kg.
The maximum injection rate is up to 0.1 g / kg, which is 1.67 ml / kg per hour.
Aminoven Infant 10%
The drug is injected mainly into the central veins.
Maximum daily dose:
- up to 1 year: 1.5–2.5 g / kg, or 15–25 ml / kg;
- 2–5 years: 1.5 g / kg, or 15 ml / kg;
- 6-14 years: 1 g / kg, or 10 ml / kg.
The maximum injection rate is up to 0.1 g / kg, which is 1 ml / kg per hour.
Side effects
Adverse events with the correct use of Aminovena Infant were not found.
In cases of infusion of the drug into peripheral veins, signs of a local reaction in the form of redness, phlebitis, thrombosis are possible. It is recommended to monitor the puncture areas daily.
Overdose
The main symptoms (if the rate of administration of the drug or dosage is exceeded): chills, vomiting, nausea, renal aminoacidosis. Acute circulatory disorders are also possible.
Therapy: immediate cancellation of the administration of Aminovena Infant. In case of hyperkalemia, a 5% glucose solution is injected at a dose of 200-500 ml, with 1-3 IU (international units) of insulin added for every 3-5 g of glucose.
special instructions
If infused too quickly, the loss of amino acids through the kidneys is possible, resulting in an imbalance of amino acids.
In young children, with parenteral nutrition, the following indicators should be taken into account: urine nitrogen, content of electrolytes, ammonia, glucose, triglycerides (with additional administration of fat emulsions), serum osmolarity, liver enzymes, water-salt metabolism and acid-base balance.
With impaired renal function
In renal failure, the dose is selected individually.
For violations of liver function
In case of liver failure, the dose is selected individually.
Drug interactions
Due to the increased risk of microbial contamination, Aminoven Infant should not be mixed with other drugs.
The addition of other substances / drugs to Aminoven Infant should be avoided, due to the likelihood of toxic reactions. In any case, you should be sure of the compatibility of the drugs, thorough mixing and maintaining sterility. Solutions with the addition of other medicines are not subject to storage.
Analogs
Analogues of Aminovena Infant are: Aminovenosis PED 6%, Aminoven, Aminoplasmal E, Aminosol-Neo, Aminosteril KE, Vamin 14 without electrolytes, Infusamin, Vaminolact, Likvamin, Nephrotect, Freamin III, Neonutrin, etc.
Terms and conditions of storage
Store in a place protected from light at temperatures up to 25 ° C, do not freeze. Keep out of the reach of children.
Shelf life is 2 years.
The solution should be used immediately after opening the bottle; if necessary, the drug can be stored for no more than 24 hours in the refrigerator.
Terms of dispensing from pharmacies
Released for hospitals.
Reviews about Aminovena Infant
Reviews about Aminovena Infant are extremely rare, since the drug is used in a hospital setting.
Price for Aminoven Infant in pharmacies
The approximate price for Aminoven Infant 10% (10 bottles of 100 ml) is 4300 rubles.
Aminoven Infant: prices in online pharmacies
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Drug name Price Pharmacy |
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Aminoven Infant 10% solution for infusion 100 ml 10 pcs. 4299 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
