Lazolvan Rino - Instructions, Use During Pregnancy, Price, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Lazolvan Reno

Lazolvan Rino: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Lasolvan Rhino

ATX code: R01AA09

Active ingredient: tramazoline (tramazoline)

Producer: Instituto de Angeli (Italy)

Description and photo updated: 2018-16-05

Prices in pharmacies: from 250 rubles.

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Lazolvan Rino is an anti-congestive agent for topical use in ENT practice.

Release form and composition

Lazolvan Rino dosage form is a dosed nasal spray: a clear solution of a pale yellow color with the smell of eucalyptus (10 ml in glass brown bottles equipped with a dispensing device and a nasal adapter with a protective cap, in a cardboard box 1 bottle).

Composition of 1 dose of the drug:

• active substance: tramazoline hydrochloride monohydrate - 82 μg (in terms of tramazoline hydrochloride);
• additional components: purified water - 66 358 mcg, povidone - 2101 mcg, glycerol 85% - 700 mcg, citric acid monohydrate - 270 mcg, sodium chloride - 183 mcg, sodium hydroxide - 154 mcg, magnesium sulfate heptahydrate - 49 mcg, hypromellose (hydroxypropyl methylcellulose) - 35 μg, magnesium chloride hexahydrate - 35 μg, L-menthol (levomenthol) - 14 μg, benzalkonium chloride - 14 μg, racemic camphor - 14 μg, calcium chloride dihydrate - 11 μg, cineole (eucalyptol) - 7 μg, sodium bicarbonate - 1 μg.

Pharmacological properties

Pharmacodynamics

Tramazoline hydrochloride - the active ingredient of Lazolvan Rino - is an alpha ₂ -adrenomimetic that has a vasoconstrictor effect. Due to vasoconstriction after contact with the nasal mucous membranes, the drug reduces their swelling, as a result of which the patency of the nasal passages is quickly restored and nasal breathing is facilitated.

The drug begins to act 5 minutes after instillation, its effect lasts for 8-10 hours.

Pharmacokinetics

The pharmacokinetics of tramazoline in humans have not been studied. In the course of studies on monkeys, rabbits and rats, it was found that when the drug is administered orally or intranasally, from 50 to 80% of the dose received is absorbed. Both tramazoline and its metabolites are distributed in all internal organs; the highest concentration was found consistently in the liver.

The main metabolites of tramazoline after oral and topical administration are determined in urine.

The half-life is 5-7 hours.

Indications for use

According to the instructions, Lazolvan Rino is prescribed to relieve swelling of the mucous membrane and eliminate nasal congestion caused by acute respiratory diseases and / or hay fever (rhinitis, hay fever).

Also, the drug can be recommended to facilitate the outflow of the contents of the paranasal sinuses with sinusitis and otitis media (eustachitis).

Contraindications

Absolute:

• atrophic rhinitis;
• angle-closure glaucoma;
• a history of instructions on previous operations on the skull, carried out through the nasal cavity;
• children under 6 years old;
• I trimester of pregnancy;
• hypersensitivity to any component of the drug.

Relative (Lasolvan Reno should be used with caution):

• heart disease;
• arterial hypertension;
• hyperthyroidism;
• porphyria;
• pheochromocytoma;
• hypertrophy of the prostate;
• the simultaneous use of tricyclic antidepressants, MAO (monoamine oxidase) inhibitors, antihypertensive or vasopressor agents.

Instructions for the use of Lazolvan Rino: method and dosage

Lazolvan Rino is administered intranasally.

Adults and children from 6 years old are prescribed 1 injection in each nostril. The frequency of instillations should not exceed 4 times a day. It is recommended to clear the nasal passages before injecting.

The duration of treatment is 5-7 days.

Use of the drug:

1. Remove the protective cap from the bottle.
2. Before the first use, press the dispenser several times into the air until a steady cloud of aerosol appears.
3. Keeping the head straight, insert the tip into the nostril and press the dispenser once.
4. Repeat the procedure for the second nasal passage.
5. Remove the tip and inhale normally through the nose.
6. Put a protective cap on the bottle.

It is recommended to clean the handpiece after each use.

Side effects

Classification of reported side effects by frequency of development: often - from ≥ 1% to <10%, infrequently - from ≥ 0.1% to <1%, rarely - from ≥ 0.01% to <0.1%, unspecified frequency - the frequency of these phenomena is not possible to assess, their relationship with the use of the drug is regarded as possible, they are registered during the post-marketing period.

Lasolvan Reno can cause the following adverse reactions:

• from the respiratory system: often - nasal discomfort; infrequently - rhinorrhea, dry nose, sneezing, swelling of the nose; rarely - nosebleeds;
• on the part of the cardiovascular system: infrequently - palpitations; unspecified frequency - increased blood pressure, arrhythmia, tachycardia;
• from the immune system: unknown frequency - hypersensitivity reactions;
• from the gastrointestinal tract: infrequently - nausea;
• from the skin and subcutaneous tissues (as symptoms of hypersensitivity): unknown frequency - rash, skin edema, itching;
• from the nervous system: rarely - disturbances in taste, dizziness; infrequently - headache; unspecified frequency - sedation, drowsiness;
• mental disorders: infrequently - anxiety; unknown frequency - insomnia, hallucinations.

Overdose

With an overdose of tramazoline, blood pressure (BP) may increase and tachycardia may occur, followed by them, especially in children, a sharp decrease in blood pressure, a decrease in body temperature, the development of reflex bradycardia and shock are possible.

Considering the experience of using other alpha-adrenergic agonists, the clinical picture of intoxication may be indistinct, which is due to the likelihood of a change in the phases of stimulation and depression of the central nervous system (CNS) and cardiovascular system (CVS), especially in children. CNS stimulation symptoms: agitation, anxiety, hallucinations, convulsions. Symptoms of CNS depression: lethargy, decrease in body temperature, drowsiness, coma.

Also, in case of an overdose, the following symptoms may develop: respiratory failure (including respiratory failure, respiratory arrest), cyanosis of the lips, miosis, mydriasis, pallor, fever, increased sweating, cardiac dysfunction (including bradycardia, cardiac arrest), mental disorders.

In case of a nasal overdose of tramazoline, it is necessary to urgently rinse the nose. When symptoms of intoxication appear, symptomatic therapy is performed.

special instructions

The recommended duration of treatment should not be exceeded. If after 7 days there is no improvement in the condition, you need to consult a doctor who will decide whether it is advisable to continue therapy or the need to stop it.

Avoid getting the spray in the eyes.

With prolonged use, Lasolvan Rino, like other vasoconstrictor nasal agents, can cause the development of chronic nasal congestion and inflammation, as well as atrophy of the nasal mucosa.

Influence on the ability to drive vehicles and complex mechanisms

Special studies on the effect of tramazoline on the reaction rate and the ability to concentrate with its intranasal use have not been carried out. However, given the risk of such side effects from the central nervous system and psyche, such as sedation, drowsiness, fatigue, dizziness and hallucinations, it is recommended to refrain from performing potentially dangerous work and driving a car during the treatment period.

Application during pregnancy and lactation

According to long-term clinical experience of use, during pregnancy, Lazolvan Rino does not have a negative effect. During lactation, the safety of using the drug has not been confirmed.

In the first trimester of pregnancy, Lazolvan Reno should not be used. In the II and III trimesters, as well as during breastfeeding, the drug can be used, but only as directed by a doctor.

Pediatric use

In pediatrics, the drug is not used to treat patients under the age of 6 years.

Drug interactions

• antihypertensive agents (especially those that affect the sympathetic nervous system): various cardiovascular effects may develop;
• tricyclic antidepressants: the risk of arrhythmias increases;
• vasoconstrictor drugs, some antidepressants (MAO inhibitors, tricyclic antidepressants): blood pressure may rise.

Analogs

There are no structural analogues of Lazolvan Reno at the moment.

Terms and conditions of storage

Store no more than 3 years at temperatures up to 25 ° C out of the reach of children.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan Reno

The drug effectively eliminates the main symptoms of the common cold, such as nasal congestion and swelling of the nasal mucosa, and is well tolerated and practically does not cause side effects. According to reviews, Lazolvan Rino helps to get rid of the symptoms of a cold in a matter of minutes and at the same time does not cause a feeling of dryness in the nose, which is characteristic of many other vasoconstrictor drugs.

However, it should be remembered that long-term use of the drug is contraindicated, since in this case there is a high risk of atrophy of the nasal mucosa.

Price for Lazolvan Reno in pharmacies

The price of Lazolvan Reno is 274–326 rubles for 1 bottle of 10 ml.

Lazolvan Reno: prices in online pharmacies

Drug name Price Pharmacy

Lasolvan Rino 1.18 mg / ml 82 μg / dose nasal spray 10 ml 1 pc. RUB 250 Buy

Lasolvan Rino nasal spray dosed 82 mcg / dose vial. 10ml 316 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!