Layfferon
Layfferon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Lifferon
ATX code: L03AB05
Active ingredient: Interferon alfa-2b human recombinant (Interferon alfa-2b human recombinant)
Manufacturer: Vector-Medica (Russia)
Description and photo update: 2018-21-11
Prices in pharmacies: from 531 rubles.
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Layfferon is a drug with antiviral, antitumor, immunomodulatory effects.
Release form and composition
Dosage forms of Layfferon:
- solution for intramuscular (intramuscular), subconjunctival injection and instillation into the eye: slightly opalescent or transparent, colorless (in a cardboard box 1 or 2 blisters of 5 ampoules / vials);
- lyophilisate for the preparation of a solution for intramuscular injection, subconjunctival administration and instillation into the eye: white hygroscopic powder or porous mass (in a cardboard box 1 or 2 blisters of 5 ampoules / vials).
Composition of 1 ampoule / bottle of solution:
- active substance: human recombinant interferon alpha-2b - 0.5; 1; 3 or 5 million IU (international units);
- auxiliary components: edetate disodium - 0.1 mg; sodium chloride - 7.5 mg; nipagin - 1 mg; sodium hydrogen phosphate dodecahydrate - 4.53 mg; oxyglutathione - 0.03 mg; sodium dihydrogen phosphate dihydrate - 1.5 mg; tween-80 - 0.1 mg; water for injection - up to 1 ml.
Composition of 1 ampoule / vial of lyophilisate:
- active substance: human recombinant interferon alpha-2b - 0.5; 1; 3 or 5 million IU;
- auxiliary components: carbamide - 0.1 mg; D-sorbitol - 3 mg; sodium chloride - 9.2 mg; sodium dihydrogen phosphate dihydrate - 0.37 mg; sodium hydrogen phosphate dodecahydrate - 2.74 mg; dextran with a molecular weight of 30,000-40,000 (in the form of a solution of Reopolyglucin, which contains 100 mg / 1 ml of dextran in 0.9% sodium chloride solution) - 8 mg.
Pharmacological properties
Pharmacodynamics
Layfferon has antiviral, immunomodulatory and antitumor activity.
Pharmacokinetics
When administered parenterally, Layfferon degrades. In unchanged form, it is partially excreted mainly by the kidneys.
With prolonged use in individuals, therapy can lead to the appearance of antibodies to interferon and, accordingly, a decrease in the therapeutic effect.
Indications for use
According to the instructions, Layfferon is prescribed as part of complex therapy.
In adult patients, indications for use are the following conditions / diseases:
- acute viral hepatitis B - moderate / severe forms at the beginning of the icteric period up to the fifth day of jaundice (at a later date, the appointment of Layfferon is less effective; with developing hepatic coma and cholestatic course of the disease, therapy is ineffective);
- stage IV kidney cancer, hairy cell leukemia, malignant skin lymphomas (fungal mycosis, primary reticulosis, reticulosarcomatosis), subleukemic myelosis, Kaposi's sarcoma, chronic myeloid leukemia, essential thrombocythemia, histiocytosis from Langerhans cell carcinoma and squamous cell carcinoma, basal cell carcinoma
- acute lingering hepatitis B and C, chronic active hepatitis B and C, including with a delta agent with / without accompanying signs of cirrhosis;
- viral (influenza, adenoviral, enterovirus, herpetic, mumps), viral-bacterial and mycoplasma meningoencephalitis. The most effective use of Layfferon in the first four days of illness;
- viral conjunctivitis, keratoconjunctivitis, keratitis, keratoiridocyclitis, keratouveitis;
- multiple sclerosis.
For children from 1 year old, Layfferon is recommended to be used for the treatment of such diseases:
- juvenile respiratory papillomatosis of the larynx (application begins the next day after removal of papillomas);
- acute lymphoblastic leukemia in remission after the end of inductive chemotherapy (at 4–5 months of remission).
Contraindications
- allergic diseases in severe forms;
- pregnancy and lactation;
- individual intolerance to the components of the drug.
Instructions for the use of Layfferon: method and dosage
Method of application of Layfferon: i / m, i / under the lesion, subconjunctivally, topically.
The lyophilisate is dissolved in water for injection or in 0.9% sodium chloride solution immediately before use. The contents of 1 ampoule / vial are diluted in the following volumes:
- 1 ml - for intramuscular use and introduction into the focus;
- 5 ml - for subconjunctival and topical administration.
The solution should be colorless, with a slight opalescence, without impurities and sediment. The dissolving time is approximately 10 minutes.
Intramuscular (i / m) administration
- acute viral hepatitis B: 1 million IU twice a day for a course of 5-6 days, after which Layfferon is administered for another five days in a daily dose of 1 million IU. According to indications (after carrying out control biochemical blood tests), treatment can be continued for two weeks at 1 million IU twice a week. The total course dose is 15–21 million ME;
- chronic viral hepatitis B with a delta agent without accompanying signs of liver cirrhosis: for 1 month, twice a week at a daily dose of 0.5-1 million IU. A second course of therapy - after 1–6 months;
- acute protracted and chronic viral hepatitis B with the exclusion of delta infection and in the absence of signs of liver cirrhosis: twice a week, 1 million IU for 1-2 months. In case of insufficiency / lack of effect, therapy can be extended up to 3–6 months or after the end of 1–2 months of therapy with an interval of 1–6 months, 2–3 similar courses are carried out;
- chronic viral hepatitis B with a delta agent and signs of liver cirrhosis: within 1 month, 0.25-0.5 million IU per day, twice a week. In cases of signs of decompensation, similar courses are repeated with intervals of at least 2 months;
- acute protracted and chronic active hepatitis C, proceeding without signs of liver cirrhosis: three times a week, 3 million IU for a course of 6–8 months. In cases where there is no therapeutic effect, the use of Layfferon can be extended up to 12 months. The repeated course is shown with a break of 3–6 months;
- viral, viral-bacterial and mycoplasma meningoencephalitis: twice a day, 1 million IU for a course of 10 days in combination with antiviral and antibacterial chemotherapy drugs. The dose and scheme of application of Layfferon is set individually based on the severity of the patient's condition;
- hairy cell leukemia: 3-6 million IU daily for 2 months. The daily dose after normalization of the hemogram should be reduced to 1-2 million IU. The dosage regimen for maintenance treatment is 3 million IU twice a week for a course of 6-7 weeks. The total course dose is 420-600 million IU and more;
- kidney cancer: 3 million IU per day for a course of 10 days. With a break of three weeks, 3–9 or more repeated courses are carried out. Heading dose of Layfferon - 120-300 million IU and more;
- malignant lymphomas and Kaposi's sarcoma: daily 3 million IU per day for a course of 10 days in combination with glucocorticosteroids and cytostatics (prospidin, cyclophosphamide). In case of reticulosarcomatosis and the tumor stage of fungal mycosis, it is advisable to use Layfferon alternately: IM 3 million ME and inside the focus 2 million ME for 10 days. With the erythrodermic stage of fungal mycosis in cases of an increase in body temperature above 39 ° C and with an exacerbation of the process, the drug is canceled. If the therapeutic effect is assessed as insufficient, Layfferon is re-prescribed after 10-14 days. After improvement of the condition, maintenance therapy is carried out once a week for 3 million IU for a course of 6-7 weeks;
- acute lymphoblastic leukemia in children in remission (Layfferon is prescribed after the end of inductive chemotherapy at 4–5 months of remission) - once a week, 1 million IU for a course of 6 months, the drug is used once every two weeks for two years. At the same time, supportive chemotherapy should be carried out;
- chronic myeloid leukemia: 3 million ME daily or every other day 6 million ME. Duration of use - from 10 weeks to six months;
- subleukemic myelosis and essential thrombocytopenia (for the correction of hyperthrombocytosis): daily or once every two days, 1 million IU for a course of 20 days;
- Langerhans cell histiocytosis: 3 million IU per day for a course of 30 days. With interruptions of 30-60 days, repeated courses are held for 1-3 years;
- multiple sclerosis: 1 million ME each; frequency of application - from one to three times a day (determined by the disease: cerebellar syndrome - 1-2 times a day, pyramidal syndrome - 3 times a day) for 10 days; in the future, Layfferon is administered once a week at 1 million ME for a course of 5-6 months. Heading dose - 50-60 million ME;
- juvenile respiratory papillomatosis of the larynx: daily at 0.1–0.15 million ME / kg for a course of 45–50 days, then 3 times a week at the same dose for a course of 1 month. The second and third courses are held with a break of 2-6 months.
In the presence of a high pyrogenic reaction to the introduction of Layfferon (at a body temperature of 39 ° C), the combined use of indomethacin and paracetamol is recommended.
Perifocal introduction
In the treatment of basal cell and squamous cell carcinoma, keratoacanthoma, Layfferon is injected under the lesion once a day, 1 million IU for a course of 10 days. In cases of pronounced local inflammatory reactions, the frequency of application is reduced to once every 2-3 days. If necessary, at the end of the course, cryodestruction is performed.
Subconjunctival introduction
In the treatment of stromal keratitis and keratoiridocyclitis, Layfferon is used daily or once every two days (depending on the severity of the process) at 0.06 million IU (in a volume of 0.5 ml). Injections should be performed under local anesthesia (0.5% dicaine solution). The duration of the course is 15-25 injections.
Local application
In the treatment of conjunctivitis and superficial keratitis, 2 drops of the prepared solution are applied to the conjunctiva of the affected eye 6-8 times a day. As the condition improves, the number of instillations is reduced to 3-4 times a day. The duration of the course is 2 weeks.
To prepare the solution, 5 ml of 0.9% sodium chloride solution for injection must be added to the contents of the ampoule (1 million IU). If it is necessary to store the solution, the rules of asepsis and antiseptics must be observed. The drug is transferred into a sterile vial with a stopper. Layfferon can be used for 12 hours at a storage temperature of 4–10 ° C.
Side effects
Possible side reactions (depending on the method of application):
- parenteral administration: flu-like syndrome, fever, chills, fatigue, malaise, headache; disorders can be partially controlled with acetaminophen / paracetamol;
- local application on the mucous membrane of the eyes: edema of the conjunctiva of the lower fornix, hyperemia of the mucous membrane of the eye, conjunctival infection, single follicles.
Also, during the use of Layfferon, deviations from the norm of laboratory parameters may be observed, which manifest themselves as leukopenia, lymphopenia, thrombocytopenia, an increase in the level of alanine aminotransferase, alkaline phosphatase. In order to timely identify these deviations during treatment, general clinical blood tests should be repeated every 14 days, biochemical ones - every 28 days. In most cases, the disorders are minor, asymptomatic and reversible.
If severe side effects develop or persist for a long period, the doctor may temporarily reduce the dose.
Overdose
There are no reports of overdose cases.
Possible symptoms: increased severity of adverse reactions.
Therapy: symptomatic or withdrawal of Lifferon.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
During the use of Layfferon, fatigue, drowsiness or disorientation may develop, in this regard, patients should refrain from driving vehicles.
Application during pregnancy and lactation
Layfferon is not prescribed during pregnancy / breastfeeding.
Drug interactions
Interferon alpha can reduce the activity of P450 cytochromes and, as a result, disrupt the metabolism of the following drugs: curantil, cimetidine, phenytoin, theophylline, warfarin, propranolol, diazepam, some cytostatics.
It is necessary to avoid combined use with drugs that depress the central nervous system, immunosuppressive drugs (including corticosteroids).
Layfferon can enhance the neurotoxic, cardiotoxic or myelotoxic effect of drugs that were prescribed earlier or simultaneously with it.
It is not recommended to drink alcohol during therapy.
Analogs
Laifferon's analogs are Intron A, Reaferon-EC, Realdiron, Interferal, Grippferon, Viferon, Interferal, Altevir, Reaferon-LIPINT, Reaferon-ES-Lipint.
Terms and conditions of storage
Store in a place protected from light at a temperature of 2-8 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Layfferon
Reviews about Layfferon are few, since it is used as part of a complex treatment. Often they indicate the development of side effects, which manifest themselves mainly in the form of a significant increase in body temperature.
The price of Layfferon in pharmacies
The approximate price for Layfferon is: solution (5 pcs. 3 million IU each) - 1308 rubles; lyophilisate (5 pcs. 1 or 3 million IU) - 536 or 1197 rubles.
Layfferon: prices in online pharmacies
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Drug name Price Pharmacy |
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Layfferon 1 million IU lyophilisate for preparing a solution for intramuscular subconjunctival administration and for instillation into the eye 5 pcs. RUB 531 Buy |
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Layferon 1 million IU solution for intramuscular subconjunctival administration and instillation into the eye 5 pcs. RUB 539 Buy |
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Layfferon 1 million IU lyophilisate for preparing a solution for intramuscular subconjunctival administration and for instillation into the eye 5 pcs. 567 r Buy |
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Layfferon 3 million IU lyophilisate for preparing a solution for intramuscular subconjunctival administration and for instillation into the eye 5 pcs. 1120 RUB Buy |
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Layfferon 3 million IU solution for intramuscular subconjunctival administration and instillation into the eye 5 pcs. 1149 RUB Buy |
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Layfferon lyoph. for prig of solution for intramuscular subconjunctiva. entered and burying. in the eye 3 million IU 5 pcs. 1271 RUB Buy |
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Layferon 5 mlnIU solution for intramuscular subconjunctival administration and instillation into the eye 5 pcs. 1834 RUB Buy |
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Layfferon 5 million IU lyophilisate for preparing a solution for intramuscular subconjunctival administration and for instillation into the eye 5 pcs. 1869 RUB Buy |
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Layfferon 5 million IU lyophilisate for preparing a solution for intramuscular subconjunctival administration and for instillation into the eye 5 pcs. 2217 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
