Femoston
Instructions for use:
- 1. Pharmacological action and pharmacokinetics
- 2. Instructions for use and dosage
- 3. Indications for use
- 4. Contraindications to use
- 5. Special instructions
- 6. Overdose
- 7. Drug interactions
- 8. Pregnancy and lactation
- 9. Side effects
- 10. Terms and conditions of storage
Prices in online pharmacies:
from RUB 665
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Pharmacological action and pharmacokinetics of Femoston
Femoston is a combination drug used for hormone replacement therapy. The active substances are estradiol and dydrogesterone. As auxiliary preparations are used: colloidal silicon dioxide, hypromellose, magnesium stearate, corn starch.
Estradiol is biologically and chemically identical to the natural human sex hormone. With the help of estradiol in a woman's body, the estrogen deficiency that occurs due to menopause is replenished, while simultaneously providing therapy for the psychoemotional and vegetative symptoms of menopause: dizziness, "hot flush", increased sweating, sleep disturbances, involutional skin processes, increased nervous irritability. Estradiol helps to maintain the tone and elasticity of the urinary tract. Also, estradiol is a prophylactic agent against osteoporosis and fractures, helps preserve bone tissue.
Dydrogesterone is a progestogenic drug that ensures the onset of the secretion phase in the inner mucous layer of the uterus, thus reducing the risk of hyperplasia and the development of carcinogenesis. Dydrogesterone has no androgenic, estrogenic, glucocorticosteroid, or anabolic activity.
The combination of estradiol and dydrogesterone in Femoston provides a low-dose regimen of hormone replacement therapy.
Research has shown that Femoston can help prevent post-menopausal bone loss caused by estrogen deficiency.
Estradiol is readily absorbed after oral administration. The drug is metabolized in the liver to form estrone and estrone sulfate. It is excreted mainly in the urine.
Dydrogesterone is readily absorbed in the gastrointestinal tract. Completely metabolized. The main metabolite of dydrogesterone is 20-dihydrodidrogesterone. Complete elimination of the drug occurs after 72 hours.
Femoston instructions for use and dosage
Femoston is taken one tablet, once a day, regardless of food intake.
Femoston 1/10 - in the first part of the 28-day cycle, consisting of 14 days, white tablets are taken containing 1 mg of estradiol. In the second half of the cycle, gray tablets containing 10 mg of dydrogesterone and 1 mg of estradiol are taken.
Femoston 2/10 - in the first part of the 28-day cycle, consisting of 14 days, pink tablets containing 2 mg of estradiol are taken. In the second half of the cycle, yellow tablets containing 10 mg of dydrogesterone and 2 mg of estradiol are taken.
For patients whose menstrual cycles have not stopped, the use of Femoston is recommended to start on the first day of the cycle. Patients who have had more than one year since their last menstrual period can start taking Femoston at any time.
Indications for Femoston's use
Like its counterparts, Femoston is used as hormone replacement therapy for disorders caused by natural menopause or menopause that occurs as a result of surgery. And also as a prevention of postmenstrual osteoporosis.
Contraindications to the use of Femoston
- suspected or diagnosed breast cancer;
- suspected or diagnosed malignant estrogen-dependent neoplasms;
- suspected or established pregnancy;
- lactation period;
- vaginal bleeding;
- deep vein thrombosis;
- porphyria;
- liver disease;
- intolerance to the components of Femoston.
Caution should be exercised in persons receiving hormone replacement therapy in the presence of the following conditions: arterial hypertension, endometriosis, uterine leiomyoma, thrombosis and the risk of their development, diabetes mellitus, benign liver tumor, cholelithiasis, migraine, systemic lupus erythematosus, renal failure, epilepsy, otosclerosis …
special instructions
When signs of deterioration in liver function, migraine-like attacks, a pronounced rise in blood pressure, pregnancy appear, Femoston should be stopped. If the development of thrombosis is observed, during therapy with Femoston, the instruction recommends the abolition of the drug.
According to the data of the studies, with the long-term use of Femoston analogues from the number of hormone replacement therapy drugs, for more than 10 years, there is a slight increase in the diagnosis of breast cancer.
Like its counterparts, Femoston is not a contraceptive; if necessary, it is recommended to combine its use with non-hormonal contraceptives.
Overdose by Femoston
The reviews received about an overdose by Femoston show that among the possible symptoms may be: nausea, vomiting, dizziness, drowsiness. For the treatment of an overdose with Femoston, the instructions recommend symptomatic therapy.
Drug interactions
When taken simultaneously with drugs-inducers of microsomal liver enzymes, such as rifampicin, phenytoin, rifabutin, carbamazepine and barbiturates, the effect of Femoston may be weakened.
Natural herbal preparations that contain St. John's wort can have a stimulating effect on estrogen metabolism.
Pregnancy and lactation
Femoston's instructions are not recommended for use during pregnancy and lactation.
Femoston side effects
From the side of the digestive system: flatulence, abdominal pain, nausea, very rarely - vomiting.
From the reproductive system possible: breakthrough bleeding, breast tenderness, pain in the pelvic region; rarely - dysmenorrhea, cervical erosion, change in secretion, premenstrual-like syndrome.
From the side of the central nervous system: migraines, dizziness, depression, nervousness.
From the side of the cardiovascular system: rarely - venous thromboembolism, extremely rarely - myocardial infarction.
Possible manifestations of dermatological and allergic reactions: rash, itching, urticaria.
According to reviews, Femoston can give side effects in the form of: vaginal candidiasis, changes in body weight, breast carcinoma, peripheral edema, changes in the curvature of the cornea.
Storage conditions and periods
Femoston should be stored out of the reach of children, at a temperature not exceeding 30 ° C. Shelf life is 3 years.
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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
