Epigenes intimacy
Epigen intima: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Epigen intim
ATX code: D06BB
Active ingredient: ammonium glycyrrhizinate (Ammonium glycyrrhizinate)
Manufacturer: Heminova International S. A. (Cheminova Internacional SA) (Spain)
Description and photo update: 2020-18-04
Prices in pharmacies: from 879 rubles.
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Epigen intim is an antiviral immunostimulating agent for external and local use.
Release form and composition
The drug is produced in the form of a spray for local and external use: from a pale yellow to pale brown color, a liquid with a characteristic odor (15 or 60 ml in a plastic bottle with a spray, each bottle is packed in a PVC film; in a cardboard box, instructions for application of Epigen intim and 1 balloon complete with a spray nozzle for intravaginal use; a free sample - 15 ml each in a plastic bottle with a spray, 1 balloon with a nozzle for intravaginal use in a cardboard box).
100 ml of spray contains:
- active substance: activated glycyrrhizic acid (equivalent to ammonium glycyrrhizinate) - 0.1 g;
- additional components: ascorbic acid, malic acid, folic acid, fumaric acid, tween 80 (polysorbate 80), purified water, propylene glycol.
Pharmacological properties
Pharmacodynamics
Activated glycyrrhizic acid is produced from licorice root through extraction. Providing a complex effect, the drug demonstrates an immunostimulating, anti-inflammatory local, antiviral, antipruritic and regenerating effect.
The active substance induces the production of its own interferons. An immunostimulating effect is manifested by an increase in the number and activity of T-lymphocytes, a decrease in the level of immunoglobulin G (IgG), and an increase in immunoglobulin A (IgA) and immunoglobulin M (IgM). The active ingredient has antiviral activity against DNA and RNA of various types of viruses in vivo and in vitro, including Varicella Zoster, cytomegalovirus (CMV), herpes simplex virus of the first (HSV-1) and second (HSV-2) type, various types of virus human papillomas, including oncogenic.
Activated glycyrrhizic acid stops the viral replication process in the early stages, leads to the release of the virion from the capsid, thereby blocking its penetration into the cell. It inactivates these viruses when used in a dose that is not toxic to normally functioning cells. Mutant viral strains that are resistant to iodouridine and acyclovir exhibit high sensitivity to glycyrrhizic acid, as well as non-mutant ones.
The stimulating effect of Epigen intima on humoral and cellular factors of immunity is combined with its anti-inflammatory activity. The drug significantly slows down the release of kinins and the production of prostaglandins by connective tissue cells in the area of inflammation. The regenerating effect is due to the improvement of reparative processes in the skin and mucous membranes.
Pharmacokinetics
In the case of external and local application, glycyrrhizic acid accumulates in the lesions. Systemic absorption is slow, it is detected in the blood in trace amounts.
Indications for use
- infection caused by the human papillomavirus, including the isolation of this virus with a high oncogenic risk in the asymptomatic course of the disease (treatment as part of complex and combination therapy);
- HSV-1 and HSV-2 infection (treatment as part of complex therapy);
- infection caused by the Varicella Zoster virus (shingles) (treatment as part of complex therapy);
- CMV infections (as part of complex therapy);
- genital warts and pathologies of the cervix, excited by the human papillomavirus, CMV (prevention and treatment);
- infections caused by HSV-1 and HSV-2, Varicella Zoster virus, CMV, human papillomavirus (prevention of relapse);
- vulvovaginal candidiasis, nonspecific vulvovaginitis, bacterial vaginosis - conditions accompanied by a decrease in local immunity (prevention and treatment as part of complex therapy);
- discomfort in the genital area, accompanied by burning, itching and dryness of the mucous membranes, including after intercourse, as well as against the background of insufficient ovarian function.
Contraindications
The use of Epigen intima is contraindicated in the presence of hypersensitivity to any of its components.
Epigen intima, instructions for use: method and dosage
Spray Epigen intim is used intravaginally, intraurethrally and externally.
Before use, the balloon with the drug must be shaken; during the procedure, it should be kept in an upright position.
For external use, the agent is recommended to be applied from a distance of 4–5 cm to the entire affected skin surface by pressing the valve 1–2 times, which is the optimal therapeutic dose.
For intravaginal administration of the spray, you should use the special nozzle with a spray attached to the preparation. Having removed the valve from the spray bottle, you need to put the nozzle valve on the bottle. After that, it is required to insert the nozzle into the vagina and, by means of 1-2 clicks, to inject, this dose has an optimal therapeutic effect.
When using Epigen intima by men, in addition to external use, the spray can be injected into the external opening of the urethra by pressing 1-2 times of the spray valve.
Recommended frequency and duration of Epigena intim application, depending on the indications:
- HSV-1 infection, shingles: apply to the lesion 6 times / day, course - 5 days; in the case of a persistent course of the infectious process, treatment is prolonged until the symptoms of the lesion completely stop;
- HSV-2 infection (genital herpes), CMV infections: externally and intravaginally 5 times / day, duration of use - 14 days; after stopping the relapse - externally and intravaginally 3 times / day, course - 10 days; in order to prevent relapses - externally and intravaginally 2 times / day, morning and evening; the course is carried out from 18-20 days of the menstrual cycle until the end of menstruation;
- papillomavirus infection: the period before removal of genital warts - 3 times / day throughout the entire stage of etiotropic treatment; period after destruction - 5 times / day for 10 days or more until complete healing; prevention of immediate relapses - 3 times / day, course - 30 days;
- progression of human papillomavirus infection (for prophylaxis): before and after intercourse, as well as when provoking factors such as fatigue, stress, microflora disturbances, respiratory viral infections, antibiotics / cytostatics are taken - intravaginally and externally 3 times / day throughout the period of exposure to these factors;
- nonspecific vulvovaginitis, vulvovaginal candidiasis, bacterial vaginosis: intravaginally 3-4 times / day, duration of treatment - 7-10 days; if necessary, repeat the course after 10 days; against the background of respiratory viral infections, taking antibiotics, cytostatics or the occurrence of other provoking factors - intravaginally and externally 3 times / day during the entire time of exposure to these factors;
- phenomena of discomfort in the genital area, accompanied by burning, itching and dryness of the mucous membranes: 2 times / day, morning and evening, course - 14–21 days; in order to prevent discomfort - regularly after intercourse.
As a prophylactic antiviral agent, Epigen Intim is recommended to be used before and after intercourse.
Side effects
During the period of drug therapy, there may be an individual intolerance to its components. In some cases, local allergic reactions may develop, including manifestations of contact dermatitis.
Overdose
No data available.
special instructions
The attachment must be washed with boiled water and soap and, after drying, stored in the enclosed polyethylene package. Thanks to its design, the nozzle allows for uniform irrigation of the cervix and vaginal walls.
When using Epigen Intim spray in a hospital setting, intravaginal irrigation in mirrors is allowed without a nozzle.
To achieve the effect of the drug, it is not required to pre-wash the application areas.
With the development of signs of intolerance, Epigen intimacy should be canceled.
Application during pregnancy and lactation
Epigen intima can be used throughout the entire period of pregnancy and lactation.
Drug interactions
- antiseptics, antibiotics, analgesics and anti-inflammatory drugs (the main groups of drugs prescribed for the complex therapy of diseases listed in the chapter "Indications for use"): the interaction of Epigen intim with these drugs has not been established;
- other antiviral substances (derivatives of iodouridine, acyclovir, interferon and other immunomodulators): potentiation of the antiviral effect was recorded.
Analogs
Analogues of Epigen intim are Alpizarin, Bonafton, Gerpferon, Locinal Intim, Myrtopleks, Reglivir, Epigen labial.
Terms and conditions of storage
Store out of the reach of children at temperatures between 15 and 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Epigenes intimacy
The reviews about Epigenes intimacy found on specialized sites are mostly positive. Many patients note the effectiveness of an immunostimulating agent in the treatment and prevention of vulvovaginal candidiasis, bacterial vaginosis, viral infections, including those caused by HSV-1 and HSV-2, as part of a combination therapy. The drug has shown good results in relieving itching, burning and other manifestations of discomfort in the intimate area. The advantage of Epigen intimacy is also considered its natural basis and the possibility of using it during pregnancy and lactation.
However, there are also negative reviews, in which they note the absence of the claimed therapeutic effect of the spray, even after its prolonged use. Many consider its high cost to the disadvantages of Epigenes intimacy.
The price of Epigen intimacy in pharmacies
The price of Epigen intim in the form of a spray for local and external use (0.1%) can be 900–990 rubles for a 15 ml bottle; for a bottle of 60 ml - 1950–2010 rubles.
Epigen intim: prices in online pharmacies
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Drug name Price Pharmacy |
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Epigen intim gel gel for external use 250 ml 1 pc. RUB 879 Buy |
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Epigen intim 0.1% spray for local and external use 15 ml 1 pc. RUB 951 Buy |
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Epigen intim gel 250ml 984 RUB Buy |
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Epigen Intim spray for local. and outside. approx. 0.1% 15ml 1099 RUB Buy |
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Epigen intim 0.1% spray for local and external use 60 ml 1 pc. 1603 RUB Buy |
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Epigen Intim spray for local. and outside. approx. 0.1% 60ml 2212 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
