Cytoflavin - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Cytoflavin

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 377 rub.

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Cytoflavin is a complex metabolic drug with a high degree of bioavailability, stimulating intracellular respiration and energy production processes in cells, improving brain metabolism, restoring antioxidant activity, activating intracellular protein synthesis, eliminating disturbances in intellectual-mnestic functions and brain sensitivity, contributing to a faster recovery of consciousness after anesthesia.

Release form and composition

• enteric-coated tablets: round, biconvex, a red shell and two layers of the core from yellow to yellow-orange are visible on the fracture (10 pcs. in blisters, 5 or 10 packs in a cardboard box);
• solution for intravenous (i / v) administration: clear yellow liquid (5 or 10 ml in ampoules of colorless / brown glass, 5 ampoules in blisters, 1 or 2 packs in a cardboard box).

1 tablet contains:

• active ingredients: succinic acid - 300 mg, nicotinamide - 25 mg, riboflavin (inosine) - 50 mg, riboflavin (sodium riboflavin phosphate) - 5 mg;
• auxiliary components: hypromellose, calcium stearate, povidone, polysorbate 80;
• enteric coating: copolymer of ethyl acrylate and methacrylic acid [1: 1], dye azorubin (E 122), propylene glycol.

1 ml of solution contains:

• active ingredients: succinic acid - 100 mg, nicotinamide - 10 mg, riboflavin (inosine) - 20 mg, riboflavin (sodium riboflavin phosphate) - 2 mg;
• excipients: sodium hydroxide, N-methylglucamine (meglumine), water for injection - up to 1 ml.

Indications for use

Enteric-coated tablets

Cytoflavin tablets are recommended for adult patients for the complex therapy of the following conditions / diseases:

• consequences of cerebral infarction;
• other cerebrovascular diseases (CVD), including hypertensive encephalopathy, cerebral atherosclerosis;
• neurasthenia, symptoms of which include fatigue, increased irritability, loss of ability to long-term mental and physical stress.

Solution for intravenous (IV) administration

Cytoflavin solution is used to treat children from birth, including premature babies (with a gestation period of 28–36 weeks), as part of the complex therapy of cerebral ischemia.

In adult patients, the solution is used in the treatment of the following conditions / diseases:

• cerebral infarction;
• consequences of CVD (cerebral infarction, cerebral atherosclerosis);
• toxic and hypoxic encephalopathy due to acute and chronic poisoning, endotoxicosis; depression of consciousness after anesthesia;
• hypoxic encephalopathy in cardiac surgery with the use of artificial circulation (therapy and prevention).

Contraindications

Absolute for all forms of release:

• pregnancy and lactation (lack of data from clinical studies on the safety and efficacy of the drug during this period);
• individual hypersensitivity to the active and auxiliary components of the drug.

Tablets are not recommended for children and adolescents under 18 years of age.

The drug in the form of a solution is not prescribed for patients (except for children during the neonatal period) in a critical condition until the central hemodynamic parameters stabilize and / or in the case of a decrease in the partial pressure of oxygen in arterial blood PaO ₂ <60 mm Hg. Art.

With caution, tablets and a solution of Cytoflavin are used by patients with nephrolithiasis, concomitant gout and hyperuricemia. If you have any of the listed diseases, you should consult your doctor before starting therapy.

In addition, pills are taken with caution for arterial hypotension, diseases of the digestive system, such as erosion, ulcers of the duodenum and / or stomach, gastritis and duodenitis (in the acute stage).

Method of administration and dosage

Enteric-coated tablets

The tablets are taken orally, without chewing, half an hour or more before meals, washed down with water in a volume of 100 ml.

Recommended dosage: 2 pcs. 2 times / day, observing the interval between doses from 8 to 10 hours, preferably in the morning and afternoon (no later than 18 hours).

The duration of the course of therapy is 25 days, a repeated course is allowed with a break of at least 1 month.

Solution for intravenous administration

In adult patients, the Cytoflavin solution is used only intravenously drip, after diluting the ampoule of the drug in 100-200 ml of sodium chloride solution (0.9%) or dextrose solution (5-10%), injected at a rate of 3-4 ml / min.

Recommended dosage:

• cerebral infarction (as early as possible from the onset of the development of the disease): 10 ml every 8-12 hours for 10 days; for the treatment of severe forms of the disease, a single dose should be increased to 20 ml;
• consequences of CVD (cerebral atherosclerosis, cerebral infarction): 10 ml once a day for 10 days;
• toxic and hypoxic encephalopathy: 10 ml every 8-12 hours for 5 days; coma - 20 ml in 200 ml of dextrose solution (5%) for 1 injection, post-anesthetic depression of consciousness - once in the same dose;
• hypoxic encephalopathy in cardiac surgery using artificial circulation: 20 ml per 200 ml of dextrose solution (5%) for 3 days before surgery, on the operating day and within 3 postoperative days.

For children (including premature babies) during the neonatal period, for the treatment of cerebral ischemia, the daily dose of Cytoflavin is determined at the rate of 2 ml per kg of the child's weight. The agent is administered intravenously drip (slowly) after dilution in a ratio of at least 1: 5 in a dextrose solution (5–10%). The first injection is made within 12 hours from birth, the first 2 hours of life are optimal for starting therapy. It is recommended to inject the prepared solution using an infusion pump, maintaining the infusion rate of 1-4 ml / h and ensuring a uniform flow of the drug into the bloodstream throughout the day. More precisely, the dose is determined based on the estimated daily volume of solutions for the main therapy, the state of hemodynamics and indicators of the acid-base state. The average course duration is 5 days.

Side effects

Enteric-coated tablets

Clinically significant side effects after taking Cytoflavin tablets: headache, pain or discomfort in the epigastric region, hypersensitivity reactions in the form of skin hyperemia and itching, hyperuricemia, transient hypoglycemia, exacerbation of concomitant gout.

If you experience / aggravate these or any other adverse reactions that are not listed in the instructions, inform your doctor about it.

Solution for intravenous administration

• immune system: very rarely - allergic reactions, anaphylactic shock, angioedema;
• nervous system: very rarely - dizziness, headache, paresthesia, tremor;
• mental disorders: very rarely - psychomotor agitation (increased physical activity, anxiety);
• heart: very rarely - a feeling of increased heart rate / strength, tachycardia, short pain and discomfort in the sternum;
• vessels: very rarely - an increase or decrease in blood pressure, pallor or hyperemia of the skin of varying severity;
• respiratory system: very rarely - sore throat, shortness of breath, difficulty breathing, dry cough, hoarseness, dysosmia, nasal paresthesia, dyspnea;
• gastrointestinal tract: very rarely - nausea / vomiting, dryness, bitterness, metallic taste in the mouth, short-term pain or discomfort in the epigastric region;
• skin and subcutaneous tissues: very rarely - rash, skin itching, swelling of the face, urticaria;
• metabolism: very rarely - hyperuricemia, transient hypoglycemia, exacerbation of gout; in children (including premature ones) during the neonatal period, alkalosis may develop;
• general disorders and disorders at the injection site: rarely - a feeling of fever, chills, weakness, sweating, fever, pain and redness along the vein (in order to avoid these effects, the recommended dose rate and dosage regimen must be observed).

If you experience / aggravate these or any other adverse reactions that are not listed in the instructions, inform your doctor about it.

special instructions

When taking Cytoflavin orally, patients with hypertension may need to adjust the doses of antihypertensive drugs taken simultaneously.

In the process of treating newborns (including premature babies) by intravenous administration of a solution of Cytoflavin, it is necessary to monitor the acid-base state of capillary blood at least 2 times a day - before and during infusion. It is also recommended to monitor serum lactate and glucose levels whenever possible.

Situations in which the rate of administration of Cytoflavin should be reduced or the infusion of the drug should be temporarily stopped in newborn (premature) children:

• the appearance of signs of respiratory-metabolic (mixed) alkalosis, which threatens to impair cerebral circulation in children on artificial respiration;
• the appearance of laboratory signs of metabolic alkalosis, threatening the appearance or increased frequency of apnea attacks, in children with preserved spontaneous breathing with respiratory support by the CPAP method (Continuous Positive Airway Pressure), or receiving an air-oxygen mixture through a mask.

Patients with diabetes mellitus are treated under the control of blood glucose concentration.

In the course of drug therapy, it is possible to stain urine in an intense yellow color.

The use of Cytoflavin does not affect the ability to drive vehicles, work with moving machines and mechanisms, perform the work of dispatchers and operators.

Drug interactions

Inosine, succinic acid and nicotinamide, which are part of Cytoflavin, are compatible with medicinal substances / preparations used simultaneously.

Pharmacological interaction of riboflavin:

• doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin: their activity decreases;
• imipramine, chlorpromazine, amitriptyline: increase the excretion of riboflavin in the urine;
• thyroid hormones: accelerate its metabolism;
• chloramphenicol: riboflavin reduces and prevents such side effects as optic neuritis, hematopoietic disorders;
• drugs that stimulate hematopoiesis, antihypoxants, anabolic steroids: riboflavin is compatible with these drugs;
• streptomycin: incompatible with riboflavin.

Analogs

There is no information on direct analogues of Cytoflavin.

Terms and conditions of storage

Store in a dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Cytoflavin: prices in online pharmacies

Drug name Price Pharmacy

Cytoflavin solution for intravenous administration 10 ml 5 pcs. 377 r Buy

Cytoflavin enteric-coated tablets 50 pcs. RUB 400 Buy

Cytoflavin solution for intravenous injection 10ml 5 pcs 564 RUB Buy

Cytoflavin enteric-coated tablets 100 pcs. RUB 682 Buy

Cytoflavin tablets p.o. enteric solution. 100 pieces. 843 RUB Buy

Cytoflavin solution for intravenous administration 10 ml 10 pcs. 979 r Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!