Celestoderm-B with garamycin
Celestoderm-B with garamycin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Celestoderm-V with garamycin
ATX code: D.07. XC01
Active ingredient: Betamethasone + Gentamycin (Betamethasonum + Gentamycinum)
Manufacturer: SCHERING-PLOUGH LABO, NV (Belgium)
Description and photo updated: 2018-11-07
Prices in pharmacies: from 358 rubles.
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Celestoderm-B with garamycin is a combined preparation containing an antibiotic aminoglycoside and a glucocorticosteroid.
Release form and composition
Dosage forms of release of the drug Celestoderm-B with garamycin:
- ointment for external use: soft, from light yellow to almost white, homogeneous, without foreign inclusions (in aluminum tubes of 15 or 30 g, in a cardboard box 1 tube);
- cream for external use: white, homogeneous, soft, free from foreign inclusions (in aluminum tubes of 15 or 30 g, in a cardboard box 1 tube).
Active substances in the composition of 1 g of ointment / cream:
- betamethasone 17-valerate - 0.001 22 g (corresponds to the content of betamethasone - 0.001 g);
- gentamicin sulfate - 0.001 g [equivalent to 0.001 g, or 1000 IU (international units) gentamicin].
Auxiliary components that make up Celestoderm-B with garamycin:
- as part of 1 g of ointment: white soft paraffin - 0.898 78 g; liquid paraffin - 0.1 g;
- as part of 1 g of cream: cetostearyl alcohol - 0.072 g; purified water - up to 1 g; white soft paraffin - 0.15 g; sodium hydroxide and phosphoric acid - until the pH is established; liquid paraffin - 0.06 g; chlorocresol - 0.001 g; macrogol cetostearyl ether - 0.022 5 g; sodium dihydrogen phosphate dihydrate - 0.003 39 g (corresponds to the content of sodium dihydrogen phosphate monohydrate - 0.003 g); phosphoric acid 0.000 02 g.
Pharmacological properties
Pharmacodynamics
The preparation Celestoderm-B with garamycin contains betamethasone valerate, a glucocorticosteroid with anti-inflammatory, antipruritic and vasoconstrictor action, and gentamicin, an antibiotic with broad-spectrum antibacterial activity. Bacteria susceptible to gentamicin include
sensitive strains of Staphylococcus aureus (coagulase-positive, coagulase-negative and some penicillinase-producing strains), as well as gram-negative bacteria - Klebsiella pneumonia, Proteus vulgaris, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa.
Indications for use
Celestoderm-B cream and ointment with garamycin is used for local therapy of skin pathologies that can be treated with glucocorticosteroids, in the presence of a secondary infection caused by microorganisms susceptible to gentamicin, or in the presence of suspicions of such an infection:
- anogenital and senile itching;
- intertrigo;
- neurodermatitis;
- eczema (children's, atopic, coin-like);
- psoriasis;
- dermatitis (contact, seborrheic, solar, exfoliative, radiation).
The preparation in the form of a cream is prescribed for patients with diseases of wet or oily skin; Celestoderm-B ointment - with skin lesions with eczema or psoriasis.
Contraindications
Absolute:
- fungal skin diseases, herpes simplex, chicken pox, skin manifestations of syphilis, skin tuberculosis;
- post-vaccination skin reactions and vaccination period;
- age less than 6 months;
- long-term therapy of large areas of skin during pregnancy;
- period of breastfeeding;
- individual intolerance to the components contained in the preparation.
Relative (diseases / conditions in the presence of which the appointment of the drug Celestoderm-B with garamycin requires caution):
- pregnancy, especially the first trimester;
- long-term therapy of large areas of the skin, especially in children;
- the presence of skin cracks;
- the use of occlusive dressings.
Instructions for the use of Celestoderm-B with garamycin: method and dosage
The ointment / cream is applied externally: a thin layer is applied to the affected skin. The frequency of use of the drug is 2 times a day (morning and evening).
The frequency of use is established by the doctor taking into account the severity of the pathology. In mild cases, it is usually sufficient to use Celestoderm-B with garamycin once a day, in more severe cases, more often.
The duration of the course of therapy directly depends on the patient's response to the drug, the location of the lesion and the degree of its severity.
Side effects
During the period of therapy with Celestoderm-B with garamycin, a violation of skin pigmentation, the development of a rash and hypersensitivity reactions are possible.
Side effects due to betamethasone (especially when using occlusive dressings):
- irritation, burning sensation, dryness, maceration, or atrophy of the skin;
- folliculitis;
- hypertrichosis;
- steroid acne;
- hypopigmentation;
- perioral dermatitis;
- allergic contact dermatitis;
- secondary infection;
- striae;
- prickly heat.
On the background of the use of gentamicin, transient skin irritation may occur, which usually does not require discontinuation of therapy.
In cases of prolonged use of Celestoderm-B with garamycin or its application to large areas, systemic side effects characteristic of glucocorticosteroids may develop:
- violation of the menstrual cycle;
- insomnia;
- excitation;
- hyperglycemia;
- exacerbation of hidden foci of infection;
- ulceration of the mucous membrane of the gastrointestinal tract;
- swelling;
- increased blood pressure;
- osteoporosis;
- increase in body weight.
Children may also develop side effects due to betamethasone:
- increased intracranial pressure (bilateral edema of the optic nerve head, headache, bulging fontanelle);
- lag in weight gain;
- growth retardation;
- Itsenko-Cushing's syndrome;
- suppression of the function of the hypothalamic-pituitary-adrenal system (including the lack of response to stimulation of adrenocorticotropic hormone, a decrease in the concentration of cortisol in the plasma).
Overdose
The main symptoms: excessive or prolonged use of local glucocorticosteroids or the use of doses exceeding the recommended ones can serve to suppress the function of the pituitary-adrenal system, which may cause symptoms of hypercortisolism, including Itsenko-Cushing's syndrome, and develop secondary adrenal cortex insufficiency. With a single overdose of gentamicin, no symptoms were observed. Prolonged use of the drug or its use in doses exceeding the recommended ones can lead to a significant growth in the lesion focus of insensitive microflora, including fungal ones.
Therapy: symptomatic treatment is prescribed. Acute symptoms of hypercortisolism are reversible in most cases. If necessary, correct electrolyte imbalance. With chronic toxic effects, treatment is gradually canceled. If there is an uncontrolled growth of insensitive microorganisms or the development of a fungal infection, the therapy is stopped and the appropriate treatment is selected.
special instructions
If the effect of treatment is absent within 14 days of using the drug, it is recommended to clarify the diagnosis.
Cancellation of the drug and the selection of appropriate therapy is required if irritation or hypersensitivity reactions develop.
Any side effects of systemic glucocorticosteroids, including suppression of the function of the adrenal cortex, can also be observed when using glucocorticosteroids for topical use, especially in children.
With the use of occlusive dressings, treatment of large body surfaces and prolonged use, the systemic absorption of local glucocorticosteroids may increase. In such situations, especially in children, it is important to observe appropriate precautions, including the possibility of canceling the drug Celestoderm-B with garamycin, which is determined by the doctor depending on the severity of the pathology.
With topical use, the systemic absorption of gentamicin may increase when applied to large areas of the skin, especially with prolonged therapy or the presence of skin cracks. In such cases, side effects characteristic of gentamicin with its systemic use may develop, and therefore its careful use is recommended, especially in children, which requires a doctor's determination of the frequency of use and the duration of treatment.
There are reports of cross-allergic reactions to antibacterial agents from the aminoglycoside group.
With prolonged local use of gentamicin, the growth of insensitive microflora, including fungal ones, is rarely observed. In such cases, as well as in the event of irritation, hypersensitivity reactions and superinfection, therapy is canceled and appropriate treatment is prescribed.
Celestoderm-B with garamycin is intended exclusively for external use and should not be used in ophthalmology.
Application during pregnancy and lactation
According to the instructions, Celestoderm-B with garamycin is contraindicated during breastfeeding. During pregnancy, long-term drug therapy of large areas of the skin is contraindicated.
The drug is used with caution during pregnancy, especially in the first trimester.
Pediatric use
The drug is contraindicated in children under 6 months of age.
Drug interactions
There are no data on the interaction of the drug Celestoderm-B with garamycin with other drugs.
Analogs
Analogs of Celestoderm-B with garamycin are: Gentazon, Betaderm, Belogent, Akriderm GENTA.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Celestoderm-B with garamycin
According to reviews, Celestoderm-B with garamycin is an effective drug in the treatment of dermatitis. Among the disadvantages are the presence of an antibiotic in it, its high cost and the absence in pharmacies.
Price for Celestoderm-B with garamycin in pharmacies
Approximate price for Celestoderm-B with garamycin:
- cream (30 g per package) - 353 rubles;
- ointment (15 g per package) - 197 rubles.
Celestoderm-B with garamycin: prices in online pharmacies
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Drug name Price Pharmacy |
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Celestoderm-B with garamycin ointment for external use 15 g 1 pc. 358 RUB Buy |
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Celestoderm-B with garamycin cream for external use 15 g 1 pc. 395 RUB Buy |
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Celestoderm-B with garamycin cream for external use 30 g 1 pc. 440 RUB Buy |
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Celestoderm-B with garamycin cream 15g 466 r Buy |
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Celestoderm-B with garamycin ointment for external use 30 g 1 pc. 497 r Buy |
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Celestoderm-B with garamycin cream 30g 557 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
