Pradaxa
Instructions for use:
- 1. Pharmacological action of the drug
- 2. Indications for the use of the drug
- 3. Instructions for use
- 4. Contraindications to use
- 5. Precautions
- 6. Side effects
- 7. Storage conditions
Prices in online pharmacies:
from 1368 rub.
Buy
Pradaxa is an antithrombotic and anticoagulant drug used in traumatology and orthopedics for the prevention of venous thromboembolism in the postoperative period. The drugs Warfarin, Fenilin and Marcumar are analogs of Pradaxa. Some reviews about Pradax say that this drug is the most effective and modern of all known coagulants.
The drug is produced in hard opaque capsules with a blue lid. Inside the capsules are yellow pellets. Dabigatran etexilate is the main active ingredient of this drug.
Pharmacological action of the drug Pradaxa
The action of the drug is to suppress the activity of thrombin. Dabigatran etexilate is a low molecular weight substance with no pharmacological activity. After oral administration, this compound is very rapidly absorbed and, upon hydrolysis, turns into dabigatran. Dabigatran is an active, competitive, reversible direct thrombin inhibitor. This substance inhibits the activity of thrombin, which binds fibrin, free thrombin, and also inhibits thrombin-induced platelet aggregation.
In medical reviews about Pradax it is said that the effectiveness of this medication is reduced by 20% with a body weight of more than 120 kg. With a body weight of about 48 kg, the effectiveness of the drug increases by 25% (in comparison with patients with an average body weight).
Indications for the use of the drug Pradaxa
The instructions for Pradaksa indicate that this drug should be prescribed for the prevention of venous or systemic thromboembolism in patients after orthopedic surgery. Pradaxa is sometimes prescribed for patients with atrial fibrillation to reduce cardiovascular mortality rates.
Instructions for use
According to the instructions, Pradaxa in capsule form should be taken once or twice a day (regardless of meal time). Do not open capsules and drink plenty of liquid.
For the prevention of venous thromboembolism, it is recommended to take 220 mg of the drug once a day (2 capsules 110 mg each). For patients with moderate renal impairment, the dose of Pradaxa should be reduced to 150 mg (two 75 mg capsules).
After knee replacement, medication should be started one to four hours after surgery. Immediately after the operation, it is recommended to take one capsule of the drug per day (110 mg), and then increase the dose to two capsules daily. The course of admission is ten days or 28-35 days (after hip arthroplasty).
Patients with atrial fibrillation need to take Pradaxa twice a day at a daily dose of 300 mg.
Contraindications to the use of Pradaxa
According to the instructions, Pradaxa and Pradaxa analogs should not be taken with known hypersensitivity to any of the components of the drug, with severe renal failure, with active clinically significant bleeding, pharmacologically induced or spontaneous disruption of homeostasis. You should not use the drug in case of liver dysfunction, malignant neoplasms, as well as with a history of intracranial hemorrhage, a history of spinal trauma or brain injury, gastrointestinal ulcer, esophageal varicose veins, intracerebral or intraspinal vascular disorders.
The simultaneous use of Pradaxa and antiplatelet agents increases the risk of bleeding three times. The use of this medication in combination with other anticoagulants is contraindicated.
There is no clinical data on the effects of taking this medication in patients under the age of 18.
Precautions
Pradaxa and Pradaxa analogues should be used with caution in conditions associated with an increased risk of bleeding. During the period of drug treatment, bleeding of various localization may develop. A decrease in the concentration of hematocrit and / or hemoglobin in the blood, which is accompanied by a decrease in blood pressure, is the basis for searching for a source of bleeding.
Side effect of Pradaxa
Many reviews about Pradax say that long-term use of the drug for prevention is sometimes accompanied by the appearance of urticaria, rash, itching, bronchospasm, diarrhea, abdominal pain, dyspepsia. Sometimes, while taking this medication, thrombocytopenia, anemia, gastroesophageal reflux disease, gastroesophagitis, hyperbilirubinemia, hematuria, urogenital bleeding, cutaneous hemorrhagic syndrome develop.
Storage conditions Pradaksa
Pradaxa in vials or blisters is stored at a temperature not exceeding 25 ° C. The product should be stored for no more than three years. After opening the bottle, the drug is recommended to be used within a month.
Pradaxa: prices in online pharmacies
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Drug name Price Pharmacy |
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Pradaxa 75 mg capsule 30 pcs. 1368 RUB Buy |
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Pradaxa 110 mg capsule 30 pcs. 1585 RUB Buy |
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Pradaxa 150 mg capsule 30 pcs. 1661 RUB Buy |
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Pradaxa capsules 150mg 30 pcs. Boehringer Ingelheim 1704 RUB Buy |
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Pradaxa capsules 75mg 30 pcs. 1756 RUB Buy |
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Pradaxa capsules 110mg 30 pcs. RUB 1817 Buy |
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Pradaxa capsules 75mg 30 pcs. 1943 RUB Buy |
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Pradaxa 110 mg capsule 60 pcs. 2891 RUB Buy |
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Pradaxa 150 mg capsule 60 pcs. RUB 2960 Buy |
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Pradaxa 150 mg capsule 180 pcs. RUB 8998 Buy |
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Pradaxa 110 mg capsules 180 pcs. RUB 9065 Buy |
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Pradaxa capsules 150mg 180 pcs. Boehringer Ingelheim RUB 9511 Buy |
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Pradaxa capsules 110mg 180 pcs. 9653 RUB Buy |
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Pradaxa capsules 110mg 180 pcs. RUB 10,419 Buy |
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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
