Postinor
Postinor: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for use a: scab and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Postinor
ATX code: G03AD01
Active ingredient: levonorgestrel (levonorgestrel)
Producer: Gedeon Richter (Hungary)
Description and photo update: 2019-16-08
Prices in pharmacies: from 384 rubles.
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Postinor is a postcoital oral contraceptive.
Release form and composition
Dosage form - tablets: in the form of a disk, almost white or white, with a chamfer, on one side there is a circular engraving “INOR. (2 pcs. In blisters, 1 blister in a cardboard box).
Active ingredient: levonorgestrel, 1 tablet - 0.75 mg.
Auxiliary components: colloidal silicon dioxide, magnesium stearate, potato starch, corn starch, talc, lactose monohydrate.
Pharmacological properties
Pharmacodynamics
Levonorgestrel is a synthetic progestogen with a contraceptive effect and a pronounced progestogenic and antiestrogenic effect. When used in the recommended doses, it suppresses ovulation and prevents fertilization if intercourse occurs in the pre-ovulation phase, which is characterized by the highest probability of fertilization. It can also lead to changes in the endometrium that prevent implantation. Postinor's effectiveness will be minimal if the implantation has already taken place.
The probability of preventing pregnancy with timely administration of the drug is about 85%. The longer the time interval between sexual intercourse and taking the drug, the less its effectiveness (95% during the first 24 hours, 85% - after 24-48 hours and 58% - after 48-72 hours). Therefore, Postinor should be taken as early as possible (but no later than 3 days after intercourse), if no contraceptive has been used. In therapeutic doses, levonorgestrel does not significantly alter blood clotting factors and does not affect the metabolism of carbohydrates and fats.
Pharmacokinetics
When taken orally, levonorgestrel is rapidly and almost 100% absorbed. After taking 0.75 mg of the drug, its maximum concentration is reached after 1.6 hours and is approximately 14.1 ng / ml. After reaching the maximum value, the concentration of levonorgestrel gradually decreases, and the half-life reaches 26 hours.
Levonorgestrel is excreted in approximately equal amounts in urine and faeces exclusively in the form of metabolites. Its biotransformation corresponds to the metabolic processes of steroids. Levonorgestrel is hydroxylated in the liver, after which its metabolites are excreted in the form of conjugated glucuronides. Metabolites of a substance with clinically significant pharmacological activity are currently unknown.
Levonorgestrel binds to sex hormone binding globulin (SHBG) and to plasma albumin. Approximately 1.5% of the administered dose of Postinor is present in the body unchanged, and 65% of the active substance binds to SHBG. Absolute bioavailability reaches almost 100% of the dose taken.
Indications for use
According to the instructions, Postinor is a drug used for emergency (post-coital) contraception (after unprotected intercourse or sexual contact using an unreliable method of contraception).
Contraindications
Absolute:
- Severe liver failure;
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- Age under 16;
- Pregnancy;
- Hypersensitivity to any of the components of the Postinor tablets.
Carefully:
- Crohn's disease;
- Jaundice (including history);
- Diseases of the biliary tract and liver;
- Lactation.
Instructions for use of Postinor: method and dosage
Postinor tablets should be taken orally. In total, you need to take 2 tablets within 72 hours after sexual intercourse, while the second tablet - 12-16 hours after taking the first.
To achieve the effect, the drug must be taken as soon as possible after intercourse (no later than 72 hours after it).
If you vomit within 3 hours of any tablet dose, you must take an additional tablet.
Side effects
- Transient adverse reactions (do not require drug treatment): often (more than 10% of cases) - lower abdominal pain, fatigue, acyclic spotting (bleeding), nausea; sometimes (in less than 10% of cases) - breast tenderness, headache, dizziness, diarrhea, vomiting, delayed menstruation (in case of a delay of more than 5-7 days, pregnancy must be excluded);
- Allergic reactions: rash, itching, hives, swelling of the face.
Overdose
An increase in the severity of side effects is considered a sign of Postinor's overdose. There is no specific antidote. If necessary, symptomatic therapy is prescribed.
special instructions
Postinor is intended solely for emergency contraception and should not be used as a permanent contraceptive method.
It should be borne in mind that this contraceptive does not protect against sexually transmitted diseases.
Postinor should be taken after unprotected intercourse as soon as possible, since its effectiveness decreases over time (%):
- Less than 24 hours - 95%;
- 25-48 hours - 85%;
- 49-72 hours - 58%.
The drug can be used on any day of the menstrual cycle, but if the cycle is irregular, pregnancy should be excluded before taking the contraceptive. Local barrier contraception (such as a cervical cap or condom) should be used before your next period. Repeated use of Postinor (after a second unprotected intercourse) during one menstrual cycle is not recommended, as the frequency of acyclic bleeding or bleeding increases.
The drug, as a rule, does not affect the course of the menstrual cycle, however, menstruation may be delayed for several days and the appearance of acyclic bleeding. If there is a delay of more than 5-7 days or a change in the nature of menstruation (abundant or scanty discharge), pregnancy must be excluded. Lower abdominal pain and fainting may indicate the development of an ectopic pregnancy.
By adolescents under 16, Postinor can only be used in exceptional cases (for example, after rape) after a mandatory consultation with a gynecologist.
If the function of the digestive system is impaired, the effectiveness of the drug may decrease.
The effect of levonorgestrel on reaction rate and the ability to concentrate has not been studied.
Application during pregnancy and lactation
Pregnancy is a strict contraindication to taking Postinor.
The results of relevant studies did not reveal a negative effect on the fetus in women who, when using this emergency contraceptive, still became pregnant.
Levonorgestrel is determined in breast milk. After taking the pills, breastfeeding should be canceled for at least 24 hours.
With impaired renal function
Information on the use of Postinor in patients with renal dysfunction is not provided by the manufacturer.
Drug interactions
Drugs that induce liver enzymes accelerate the metabolism of levonorgestrel.
The following drugs can reduce the effectiveness of Postinor: St. John's wort preparations, tacrolimus, oxcarbazepine, topiramate, nevirapine, tretinoin, lansoprazole, amprecavil, barbiturates, incl. primidone, phenytoin and carbamazepine, tetracycline, ritonavir, rifabutin, ampicillin, griseofulvin, rifampicin.
Levonorgestrel increases plasma concentrations of glucocorticosteroids, reduces the effectiveness of anticoagulants (coumarin derivatives, phenindione) and hypoglycemic drugs. Women who take these funds should consult a doctor before using Postinor.
Levonorgestrel inhibits the metabolism of cyclosporine, thereby increasing the risk of its toxicity.
Analogs
Postinor's analogs are: Ginepriston, Zhenale, Escapel, Laktinet, Eskinor-F, Implanon, Charosetta, Mifepriston, Exluton.
Terms and conditions of storage
Keep out of the reach of children at a temperature of 15 to 25 ºС.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Postinor
On the Internet there are a variety of reviews about Postinor. Most women claim that the drug allows you to successfully avoid an unplanned pregnancy, but taking it is often accompanied by severe side reactions: severe bleeding, intense pain in the lower abdomen, and absence of menstruation.
Gynecologists believe that patients tolerate the use of levonorgestrel better than the Yuzpe method, which is an alternative to using Postinor and involves taking high-dose pills as regular contraception. Also, the drug is often more effective than the above method.
However, most experts advise using a contraceptive only if absolutely necessary: after unprotected intercourse or rape, if a woman has spontaneous prolapse of the IUD, or a condom breaks during intercourse, while skipping another contraceptive pill. This is due to the fact that the consequences of taking Postinor can be serious and unexpected, depending on the individual reaction of the woman's body to a high dose of levonorgestrel. Some doctors argue that regular and uncontrolled use of the drug can cause irreparable harm to a woman's health and even lead to infertility. Therefore, only occasional intake of the drug is allowed, and if it is necessary to take it again, patients should think about the selection of regular contraception,which act on the body is much milder. Also, after taking the pill, you should not drink alcoholic beverages.
The price of Postinor in pharmacies
The approximate price for Postinor in pharmacies varies from 358 to 500 rubles (2 pcs in a package).
Postinor: prices in online pharmacies
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Drug name Price Pharmacy |
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Postinor 0.75 mg tablets 2 pcs. 384 r Buy |
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Postinor tablets 0.75mg 2 pcs. 404 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
