Suprima-kof - Instructions For Use, Price Of Tablets, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Suprima-kof

Suprima-kof: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Suprima-Kof

ATX code: R05CB06

Active ingredient: ambroxol (Ambroxol)

Manufacturer: Shreya Life Science, Pvt. Ltd. (Shreya Life Sciences, Pvt. Ltd.) (India)

Description and photo update: 2020-17-01

Prices in pharmacies: from 194 rubles.

Buy

Suprima-kof is a drug with mucolytic and secretolytic activity, a stimulator of the motor function of the respiratory tract.

Release form and composition

Dosage form of the drug - tablets: round, with beveled edges, from white to white-yellowish color, with a risk on one side (10 tablets in blisters, in a cardboard box 1-2 blisters and instructions for use of Suprima-kof).

Composition for 1 tablet:

• active substance: ambroxol (in the form of hydrochloride) - 30 mg;
• auxiliary components: propyl parahydroxybenzoate, croscarmellose sodium, corn starch, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch, methyl parahydroxybenzoate, calcium hydrogen phosphate, talc.

Pharmacological properties

Pharmacodynamics

The active substance of Suprima-kof - ambroxol hydrochloride, is a mucolytic agent with a secretolytic, secretomotor, expectorant effect.

The mechanism of action of the substance is due to the stimulation of serous cells of the glands of the bronchial mucosa, an increase in the content of mucous secretions and the release of a surfactant (surfactant) in the alveoli and bronchi. Ambroxol activates hydrolyzing enzymes and enhances the release of lysosomes from Clara cells, which leads to a decrease in sputum viscosity. It also has the ability to increase the motor activity of the ciliated epithelium and increase mucociliary transport.

With oral administration, the effect of Ambroxol develops within 30 minutes and lasts up to 6-12 hours.

Pharmacokinetics

Ambroxol hydrochloride is highly absorbed. The maximum plasma concentration (C _max) is reached within 2 hours. About 80% of the agent binds to plasma proteins.

The drug penetrates the blood-brain and placental barriers, as well as into breast milk.

Biotransformed in the liver, resulting in the formation of glucuronic conjugates and dibromantranilic acid.

The drug is excreted by the kidneys: about 5% - unchanged, about 90% - in the form of water-soluble metabolites. The half-life (T _1/2) varies from 7 to 12 hours, it does not change in patients with impaired liver function, but increases in severe chronic renal failure.

Indications for use

Suprima-kof is prescribed for the treatment of diseases of the respiratory tract, accompanied by the formation of viscous sputum, such as:

• acute and chronic bronchitis;
• chronic obstructive pulmonary disease;
• bronchiectasis;
• pneumonia;
• bronchial asthma, in which sputum discharge is difficult.

Contraindications

Absolute:

• children under 5 years old;
• I trimester of pregnancy;
• known hypersensitivity to any component of the drug.

Suprima-kof tablets should be used with caution in case of gastric ulcer and duodenal ulcer, renal and / or liver failure.

Suprima-kof, instructions for use: method and dosage

Suprima-kof is indicated for oral administration. The tablets should be swallowed whole with enough liquid.

Recommended dosage regimen depending on the patient's age:

• children 6-12 years old: ½ tablet 2-3 times a day (daily dose 30-45 mg), after 2-3 days - ½ tablet 2 times a day (daily dose 30 mg);
• adolescents from 12 years old and adults: 1 tablet 3 times a day (total dose - 90 mg), after 2-3 days - 1 tablet 2 times a day (60 mg) or ½ tablet 3 times a day (45 mg).

In severe cases of the disease, the dose is not reduced during the entire treatment period.

Side effects

Suprima-kof is generally well tolerated. In rare cases, it causes the following side effects:

• from the digestive system: dry mouth, diarrhea, constipation; with prolonged use in high doses - heartburn, nausea, vomiting, gastralgia;
• from the nervous system: headache, weakness;
• from the respiratory system: rhinorrhea, dryness in the airways;
• on the part of the skin: exanthema;
• from the urinary system: dysuria;
• allergic reactions; urticaria, skin rash, allergic contact dermatitis, Quincke's edema, anaphylactic shock.

Overdose

An overdose of ambroxol is manifested by nausea, dyspepsia, diarrhea, and vomiting.

In case of taking an excessive dose of Suprima-kof, if no more than 1–2 hours have passed, induction of vomiting, gastric lavage, and the use of fat-containing foods are recommended. Overdose treatment is symptomatic.

special instructions

Suprima-kof should be used with caution in patients with impaired mucociliary transport or a weakened cough reflex, since they have a risk that sputum will accumulate.

Influence on the ability to drive vehicles and complex mechanisms

The components in the composition of the Suprima-kof tablets do not have a negative effect on the speed of reactions, do not reduce the ability to concentrate.

Application during pregnancy and lactation

The drug is contraindicated in the first trimester of pregnancy.

In the II-III trimesters of pregnancy and during lactation, mucolytic can be used only in cases where the expected benefit to the mother is higher than the potential risks to the fetus / child. Care must be taken.

Pediatric use

Suprima-kof is not used to treat children under 5 years of age.

With impaired renal function

Suprima-kof tablets should be taken with caution in patients with renal insufficiency.

For violations of liver function

A mucolytic drug should be used with caution in patients with hepatic impairment.

Use in the elderly

Elderly patients should take Suprima-kof tablets with caution.

Drug interactions

During treatment with ambroxol, you should avoid taking antitussives (for example, containing codeine), since they, by reducing cough, make it difficult for sputum to pass.

Suprima-kof increases the penetration into the bronchial secretion of antibiotics such as amoxicillin, cefuroxime, doxycycline, erythromycin.

Analogs

Analogues of Suprima-kof are Ambrohexal, Halixol, Ambrobene, Ambroxol, Ambrosan, Bromhexin, Bronchorus, Solution Tablets, Bronchoxol, Vicks Active AmbroMed, Zvezdochka Broncho, Lazongin, Lazolvan, Orvis Broncho, Neo-Bronhollava Taboleth and Rembrox dr.

Terms and conditions of storage

Store in a dry place out of reach of children at temperatures up to 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Suprima-kof

According to reviews, Suprima-kof is an effective mucolytic agent that well reduces the viscosity of sputum and improves its discharge. Effective for wet coughs.

Price for suprima coffee in pharmacies

The price of Suprima-kof in the form of 30 mg tablets is approximately 188 rubles. per pack of 20

Suprima-coffee: prices in online pharmacies

Drug name Price Pharmacy

Suprima-kof 30 mg tablets 20 pcs. 194 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!