Ketoaminol
Ketoaminol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Ketoamynol
ATX code: V06DD
Active ingredient: amino acids (aminoacids)
Manufacturer: Nanjing Baijingyu Pharmaceutical Co. Ltd (China)
Description and photo update: 28.11.2018
Prices in pharmacies: from 3137 rubles.
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Ketoaminol is a drug that has a metabolic effect that replenishes amino acid deficiencies. It is used for renal failure as a nutrient.
Release form and composition
Dosage form - film-coated tablets: oblong, biconvex, yellow; the cross-section shows the core of almost white or white color (20 pcs. in blisters, 5 packs in bags, 1 bag in a cardboard box and instructions for use of Ketoaminol).
Active ingredients in 1 tablet:
- lysine monoacetate - 105 mg;
- 4-methyl-2-oxo-valerate calcium (alpha-ketoanalogue leucine) - 101 mg (calculated on dry matter);
- 3-methyl-2-oxo-butyrate calcium (valine alpha-ketoanalogue) - 86 mg (in terms of dry matter);
- 2-oxo-3-phenyl-calcium propionate (phenylalanine alpha-ketoanalogue) - 68 mg (in terms of dry matter);
- D, L-3-methyl-2-oxo-calcium valerate (isoleucine alpha-ketoanalogue) - 67 mg (in terms of dry matter);
- 2-hydroxy-4-methylthio-butyrate calcium (methionine alpha-hydroxyanalogue) - 59 mg (in terms of dry matter);
- threonine - 53 mg;
- histidine - 38 mg;
- tyrosine - 30 mg;
- tryptophan - 23 mg.
The total nitrogen content is 36 mg, calcium is 50 mg (1.25 mmol).
Additional components:
- excipients: starch, povidone K30, macrogol 6000, silicon dioxide, magnesium stearate, microcrystalline cellulose, talc, crospovidone;
- composition of the film shell: macrogol 6000, methacrylic acid and ethyl acrylate copolymer (1: 1), talc, titanium dioxide, quinoline yellow dye.
Pharmacological properties
Pharmacodynamics
Ketoaminol ensures the intake of essential amino acids into the patient's body with renal insufficiency with minimal nitrogen intake.
After absorption, keto and hydroxy acids are transaminated to form the corresponding essential amino acids, while the amino group is transferred from the nonessential amino acids. Due to the repeated use of the amino group, the accumulation of uremic toxins decreases, the formation of urea slows down.
In the remaining nephrons, hydroxy and keto acids do not cause hyperfiltration. The drug has a beneficial effect on renal hyperphosphatemia and secondary hyperparathyroidism. In some cases, it even improves the course of osteodystrophy.
The use of Ketoaminol in combination with a low protein diet reduces nitrogen intake, while preventing the development of adverse events that usually occur due to insufficient protein intake and malnutrition.
Pharmacokinetics
In patients with uremia, the processes of absorption of amino acids, apparently, do not cause disturbances in their plasma concentrations, i.e., their absorption is not disturbed. Changes in plasma concentrations presumably occur at stages following the absorption of amino acids; they are detected at an early stage of the disease.
In healthy volunteers, plasma keto acid concentrations increase within 10 minutes after oral administration of ketoaminol. Depending on individual characteristics, an increase in concentration is possible up to 5 times from the initial one.
The maximum plasma concentrations (C max) are noted after 20-60 minutes, after 90 minutes they return to the initial. Thus, the absorption of the drug from the gastrointestinal tract is rapid.
The simultaneous increase in plasma levels of keto acids and the corresponding amino acids suggests a high rate of transamination. Given the presence of physiological pathways for the utilization of keto acids in the human body, exogenous keto acids are likely to be quickly incorporated into metabolic cycles. They go through catabolic pathways similar to those of regular amino acids.
The elimination of keto acids has not been studied.
Indications for use
Ketoaminol is prescribed for adult patients with chronic renal failure to prevent and treat disorders caused by abnormal protein metabolism. The drug is used in combination with a low-protein diet, not exceeding the daily amount of protein 40 g. The glomerular filtration rate in patients usually does not exceed 25 ml / min.
Contraindications
- hypercalcemia;
- violation of amino acid metabolism;
- age up to 18 years;
- breastfeeding (there is no experience with the drug during this period);
- individual hypersensitivity to any component of Ketoaminol.
The drug should be used with caution in the treatment of patients with hereditary phenylketonuria, since the tablets contain phenylalanine.
Due to the lack of clinical data, taking the drug during pregnancy requires caution.
Ketoaminol, instructions for use: method and dosage
Ketoaminol tablets should be taken orally, with food: swallow whole with enough liquid, without chewing or biting.
The daily dose for adults is 1 tablet for every 5 kg of body weight or 0.1 g / kg. Thus, a patient weighing 70 kg is usually prescribed 4–8 tablets 3 times a day.
The drug is recommended to be taken while the patient is on a low-protein diet (no more than 40 g of protein per day), and the glomerular filtration rate does not exceed 25 ml / min.
Side effects
In very rare cases, the drug causes the development of hypercalcemia. In this case, first reduce the dose of vitamin D. If the disorder persists, reduce the dose of Ketoaminol and other sources of calcium.
Overdose
Overdose cases have not been reported to date.
special instructions
Taking the drug with food improves absorption and metabolism to the corresponding amino acids. It is necessary to provide sufficient caloric content of food.
Serum calcium levels should be monitored regularly throughout the therapy period.
In the case of the simultaneous use of aluminum hydroxide or phosphates, it is necessary to control their serum concentration.
Influence on the ability to drive vehicles and complex mechanisms
The components in the Ketoaminol composition do not have a negative effect on the cognitive and psychophysical functions of a person.
Application during pregnancy and lactation
In preclinical studies, no direct or indirect negative impact on the course of pregnancy, embryofetal development, the process of childbirth and postnatal development was revealed. However, there are no clinical data on the use of Ketoaminol in pregnant women, and therefore the drug should be used with caution during this period.
There is no experience with the use of Ketoaminol during lactation.
Pediatric use
The drug is not prescribed to patients under the age of 18, which is due to the lack of data on the efficacy and safety of its use in this age group.
Drug interactions
You should not take Ketoaminol tablets at the same time as drugs that can form poorly soluble compounds with calcium (for example, tetracyclines, fluoride, iron and estramustine preparations, quinolone derivatives such as norfloxacin and ciprofloxacin). If it is necessary to use such combinations, you should maintain at least two-hour intervals between their receptions.
With the combined use of calcium preparations, the development or enhancement of hypercalcemia is possible.
As the serum calcium concentration increases, the sensitivity to cardiac glycosides increases and, as a result, the risk of arrhythmia increases.
Phosphates should be used with caution (monitoring of their serum concentration is required).
As uremic symptoms decrease while taking Ketoaminol, it is necessary to reduce the dose of simultaneously used aluminum hydroxide.
Analogs
Analogs of Ketoaminol are: Ketosteril, Keto analogs of amino acids, Likvamin, Vaminolact, Neonutrin, Aminosteril II Novum, Aminosteril III Novum, Vamin 14, etc.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C in a place out of the reach of children, protected from moisture and light.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ketoaminol
There are no reviews of Ketoaminol on the forums and sites, therefore, it is not possible to assess the degree of effectiveness and tolerability of the drug based on patient reports.
The price of Ketoaminol in pharmacies
Depending on the pharmacy chain, the price of Ketoaminol per pack containing 100 tablets can be 2250–3500 rubles.
Ketoaminol: prices in online pharmacies
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Drug name Price Pharmacy |
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Ketoaminol film-coated tablets 100 pcs. RUB 3137 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
