Lazolvan MAX - Instructions For Use, Price, Reviews, Analogs, Price

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Lazolvan MAX

Lazolvan MAX: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. In case of impaired liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Lasolvan Max

ATX code: R05CB06

Active ingredient: ambroxol (ambroxol)

Manufacturer: Boehringer Ingelheim (Germany)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 204 rubles.

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Lazolvan MAX is an expectorant, mucolytic.

Release form and composition

Lazolvan MAX dosage form - capsules of prolonged action: hard gelatinous, oblong, orange, with the symbol of the manufacturer's company (Boehringer Ingelheim); the capsule cap is red and the inscription "MUC 01" is white. The contents of the capsule are yellowish-white shiny granules, a small amount of powder.

Composition of 1 capsule:

• active substance: ambroxol hydrochloride - 75 mg;
• auxiliary components: crospovidone, carnauba wax, stearyl alcohol, magnesium stearate;
• capsule: gelatin, purified water, titanium dioxide, dyes - iron oxide red and yellow, ink (shellac, titanium dioxide).

Pharmacological properties

Pharmacodynamics

Ambroxol has the ability to increase the secretion of the respiratory tract, enhance the production of pulmonary surfactant and stimulate ciliary activity. This increases the flow and transport of mucus (mucociliary clearance), which promotes better sputum discharge and relieves coughing.

With prolonged (at least 60 days) use of the drug by patients with chronic obstructive pulmonary disease, a significant decrease in the number and duration of exacerbations and the number of days of antibiotic therapy was noted.

Pharmacokinetics

Ambroxol is rapidly and almost completely absorbed. The maximum plasma concentration after taking one capsule is achieved in 6.5 hours. The relative bioavailability of the drug is 95%. The connection with plasma proteins is 90%.

When taken orally, Ambroxol quickly passes from the blood to the tissues. Its volume of distribution is 552 liters. The highest concentration is observed in the lungs. 70% of the dose of ambroxol is metabolized in the liver, mainly by glucuronidation and by partial degradation. About 30% of the drug is exposed to the effect of the first pass through the liver. Ambroxol is metabolized to dibromantranilic acid mainly through the CYP3A4 isoenzyme.

The thermal half-life is approximately 10 hours. The total clearance is 660 ml / min. 83% of the single dose taken is excreted in the urine within 5 days. Age and gender have no effect on the pharmacokinetics of the drug.

Indications for use

According to the instructions, Lazolvan MAX is indicated for the treatment of the following respiratory diseases, accompanied by the separation of viscous sputum:

• pneumonia;
• acute and chronic bronchitis;
• chronic obstructive pulmonary disease;
• bronchiectasis;
• bronchial asthma, accompanied by obstructed sputum discharge.

Contraindications

Absolute contraindications:

• age up to 18 years;
• pregnancy (I trimester) and lactation;
• increased sensitivity to the components of the drug.

Relative contraindications:

• renal failure;
• liver failure;
• pregnancy (II – III trimesters).

Instructions for use of Lazolvan MAX: method and dosage

Lazolvan MAX capsules are taken orally, regardless of food intake, whole, without opening or chewing, drinking plenty of liquid.

It is recommended to take 1 capsule of prolonged action per day.

If the symptoms of the disease persist within 4-5 days of taking the drug, it is recommended to consult a doctor.

Side effects

• gastrointestinal tract: nausea, vomiting, dyspepsia, abdominal pain;
• skin, subcutaneous tissues and the immune system: rash, urticaria, itching, hypersensitivity reactions, angioedema, anaphylactic reactions (including anaphylactic shock).

Overdose

In case of an overdose of Lazolvan MAX, there may be side effects of the drug, such as nausea, vomiting, dyspepsia, diarrhea, abdominal pain.

Recommended treatment: gastric lavage within 1-2 hours after taking the drug, symptomatic therapy.

special instructions

There are isolated reports of cases of the development of Stevens-Johnson syndrome and toxic epidermal necrolysis during the period of treatment with expectorants. In this regard, if signs of these diseases appear and worsen (lesions of the skin and mucous membranes, fever, body pain, rhinitis, cough, sore throat), the drug should be discontinued and a doctor should be consulted.

Influence on the ability to drive vehicles and complex mechanisms

Studies of the effect of Lazolvan MAKS on the ability to drive vehicles and other complex mechanisms that require the speed of psychomotor reactions have not been conducted.

Application during pregnancy and lactation

Ambroxol is able to penetrate the placental barrier. The studies did not reveal an undesirable effect of the drug on pregnancy, embryonic, fetal, postnatal development and childbirth. Numerous data on its use after the 28th week of pregnancy did not reveal a negative effect on the fetus. However, in the first trimester, Lasolvan MAX is contraindicated. Its use in the II and III trimesters is possible only when the expected benefit to the mother outweighs the possible risk to the fetus.

Ambroxol may be excreted in breast milk, and therefore the drug is contraindicated for use during lactation.

Pediatric use

Lazolvan MAX is contraindicated for use in pediatrics.

With impaired renal function

In case of impaired renal function, taking the drug is permissible only as directed by a doctor. The drug is contraindicated in renal failure.

If liver function is impaired

Lasolvan MAX should not be taken by patients with hepatic impairment.

Use in the elderly

Elderly patients do not need dose adjustment.

Drug interactions

When ambroxol is taken together with amoxicillin, cefuroxime and erythromycin, the penetration of these drugs into the bronchial secretion increases.

It is contraindicated to use Lazolvan MAX with antitussive drugs that impede the excretion of sputum.

Analogs

Lazolvan MAX analogs are Ambrobene, Ambrohexal, Ambroxol, Ambrolor, Ambrosan, Bronchoxol, Bronchorus, Vicks Active AmbroMed, Lazongin, Medox, Neo-Bronchol, ORVIS Broncho, Remebrox, Suprima-kof, Toraxol Solushned Tabletts, Follys.

Terms and conditions of storage

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan MAX

Reviews of Lazolvan MAX indicate the effectiveness of the drug in the fight against cough. The convenience of use is especially noted, since you need to drink it only once a day. There are isolated reports of the absence of the drug's effect, and among the minuses, the high cost and the presence of contraindications are also mentioned.

Price for Lazolvan MAX in pharmacies

The approximate price for Lazolvan MAX (capsules of prolonged action 75 mg, 10 pcs.) Is 230 rubles.

Lazolvan MAX: prices in online pharmacies

Drug name Price Pharmacy

Lazolvan Max 75 mg capsules of prolonged action 10 pcs. 204 RUB Buy

Lazolvan Max capsules prolonged action 75mg 10 pcs. 245 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!