Ladasten
Ladasten: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Ladasten
ATX code: A.13. A
Active ingredient: Adamantilbromphenylaminum (Adamanthylbromphenylaminum)
Manufacturer: LEKKO, CJSC (Russia)
Description and photo update: 2018-24-10
Ladasten is an antiasthenic drug.
Release form and composition
Ladasten is produced in the form of tablets: white with a creamy shade or white, flat-cylindrical, round, with a bevel; 100 mg - with a risk (in blisters of 25 pcs., in a cardboard box 1 or 2 packs).
Composition of 1 tablet:
- active substance: adamantyl bromophenylamine (adamantylphenylamine) - 50 or 100 mg;
- auxiliary components: magnesium stearate, microcrystalline cellulose, potato starch.
Pharmacological properties
Pharmacodynamics
Ladasten is an adamantane derivative that has a positive effect on mental and physical performance.
The actions of the drug due to its constituent components:
- has an immunostimulating, anxiolytic, activating effect;
- shows actoprotective activity;
- does not possess addictive potential, muscle relaxant and hypnosedative properties, due to which, unlike other psychostimulants, it practically does not cause the phenomenon of hyperstimulation, depletion of the body's functional capabilities;
- helps to increase endurance and restore activity;
- shows its therapeutic effect in the form of a distinct reduction in somatovegetative manifestations, indicators of emotional stress, asthenic symptoms in the first days of treatment in asthenic and anxiety-asthenic disorders;
- enhances GABAergic mediation by decreasing the expression of the gene that reuptakes the mediator that controls the synthesis of the GABA transporter.
The mechanism of action of the drug is associated with an increase in the release of dopamine from presynaptic terminals, a blockade of its reuptake, and an increase in biosynthesis, which is due to the expression of the tyrosine hydroxylase gene and its modulating effect on the GABA-benzodiazepine-chlorion-form receptor complex that develops under stress, eliminating a decrease in the benzodiazepine receptor complex.
The drug is non-toxic.
Pharmacokinetics
Characteristics of adamantyl bromophenylamine (adamantylphenylamine):
- absorption: T max (time to reach maximum concentration) - 2–4 hours; C max (maximum concentration in blood plasma) - 363.3 ng / ml;
- Excretion: T½ (half-life) - 11.21 hours.
Indications for use
- neurasthenia;
- asthenic conditions of various origins, including somatic pathologies and after infectious diseases.
Contraindications
- age under 18;
- pregnancy;
- period of breastfeeding;
- individual intolerance to the components of the drug.
Instructions for the use of Ladasten: method and dosage
The tablets are taken orally, regardless of food, until 4 pm (later the drug is not recommended to be taken).
The optimal single dose is 0.05–0.1 g; daily - 0.1-0.2 g, divided into 2 doses.
The duration of therapy is 14–28 days.
Side effects
During the period of taking Ladasten, sleep disorder and excessive activation may develop, which does not require discontinuation of therapy, but in such cases it is advisable to reduce the dose of the drug.
In case of hypersensitivity to the components of the drug, allergic reactions may develop.
Overdose
Main symptoms: sedation.
Therapy: non-specific detoxification treatment.
special instructions
Before starting treatment with Ladasten, you should consult your doctor.
Application during pregnancy and lactation
According to the instructions, Ladasten is contraindicated for use during pregnancy and lactation.
Pediatric use
The drug is contraindicated in children under the age of 18.
Drug interactions
With the combined use of adamantyl bromophenylamine (adamantylphenylamine) with sodium thiopental, the hypnotic effect of the second decreases, with benzodiazepines - their anxiolytic effect remains unchanged.
Analogs
Ladasten's analogues are: Stimol, Milayf, Bemaktor, Fitovit, Apilak, Pantokrin, Gerimaks, Metaprot, Biosed.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ladasten
According to reviews, Ladasten in some cases is a fast-acting and effective drug, in others - on the contrary, absolutely ineffective and causing side effects.
Price for Ladasten in pharmacies
The approximate price of Ladastena (25 tablets per pack) is 298 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
