Lipothioxone
Lipothioxone: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Lipothioxon
ATX code: A16AX01
Active ingredient: thioctic acid (Thioctic acid)
Producer: Sotex PharmFirma (Russia)
Description and photo update: 28.11.2018
Prices in pharmacies: from 339 rubles.
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Lipothioxone is a metabolic agent with hypolipidemic, hepatoprotective, hypoglycemic and hypocholesterolemic effects.
Release form and composition
Dosage form - concentrate for preparation of solution for infusion: clear liquid from greenish to light yellow color (in a cardboard box 1 blister or plastic package containing 5 ampoules of 12 or 24 ml each, and instructions for the use of Lipothioxone).
Composition for 1 ampoule:
- active substance: thioctic (α-lipoic) acid - 300 or 600 mg (in the form of meglumine thioctate - 583.86 or 1167.72 mg; formed as a result of the interaction of thioctic acid and meglumine);
- auxiliary components (300/600 mg): anhydrous sodium sulfite - 6/12 mg; macrogol-300 - 2400/4800 mg; meglumine - up to pH 8-9 (12.5-35 mg / 25-70 mg); edetate disodium - 6/12 mg; water for injection - up to 12/24 ml.
Pharmacological properties
Pharmacodynamics
Thioctic (α-lipoic) acid is an endogenous antioxidant that binds free radicals, the formation of which in the body occurs during the oxidative decarboxylation of α-keto acids. As a coenzyme of mitochondrial multienzyme complexes, thioctic acid is involved in the oxidative decarboxylation of α-keto acids and pyruvic acid.
Lipothioxone has hepatoprotective, hypolipidemic, hypoglycemic and hypocholesterolemic effects. By the nature of the biochemical effect, α-lipoic acid is close to the B vitamins.
The main effects of thioctic acid:
- a decrease in the concentration of glucose in the blood;
- increased glycogen in the liver;
- overcoming insulin resistance;
- participation in the regulation of carbohydrate and lipid metabolism;
- stimulation of cholesterol metabolism;
- improving the functional state of the liver and increasing the trophism of neurons.
Pharmacokinetics
The maximum concentration of thioctic acid when administered intravenously is reached in 10-11 minutes, it is 0.025-0.038 mg / ml. The area under the concentration-time curve is ~ 0.005 mg h / ml. Bioavailability at the level of 30%.
The substance has the effect of the first passage through the liver. The formation of metabolites is associated with conjugation and oxidation of the side chain.
The volume of distribution is ~ 450 ml / kg. Excretion of the substance and its metabolites occurs mainly by the kidneys (from 80 to 90%). The half-life is 20-50 minutes. The total plasma clearance is in the range of 10-15 ml / min.
Indications for use
Lipothioxone is prescribed for the treatment of diabetic and alcoholic polyneuropathy.
Contraindications
- pregnancy and lactation;
- children and adolescents under 18 years of age;
- individual intolerance to the components of the drug.
Lipothioxone, instructions for use: method and dosage
Lipothioxone is administered intravenously as an infusion after dilution in isotonic sodium chloride solution.
In severe pathology, the solution is injected once a day at a dose of 300-600 mg drip for 50 minutes.
The recommended duration of therapy is 2–4 weeks. At the end of this period, treatment is continued with oral administration of thioctic acid in the same dose for a minimum period of 3 months.
Side effects
In very rare cases, against the background of the administration of Lipothioxone, the development of disorders in the form of seizures, diplopia, thrombophlebitis, punctate hemorrhages in the skin and mucous membranes, hemorrhagic rash (purpura), thrombocytopathy is noted.
If the solution is injected quickly, breathing difficulties and an increase in intracranial pressure (manifested as a feeling of heaviness in the head) are possible. These side reactions usually go away on their own.
Urticaria, systemic allergic reactions (up to anaphylactic shock) may occur.
Improving glucose uptake can lead to the development of hypoglycemia.
Overdose
Main symptoms: vomiting, nausea, headache.
Therapy: symptomatic. The specific antidote is unknown.
special instructions
Patients with diabetes mellitus, especially at the beginning of the use of Lipothioxone, require frequent monitoring of the concentration of glucose in the blood. Sometimes the dose of hypoglycemic agents must be reduced.
It is recommended to refrain from drinking alcohol during the treatment period, since it reduces the effect of the therapy.
Ampoules should be taken out of the package only immediately before use, since Lipothioxone has a high photosensitivity. During the infusion, it is advisable to protect the bottle with the solution from exposure to light by wrapping it with aluminum foil or placing it in light-protective bags.
After dilution, Lipothioxone should be used within 6 hours, provided it is stored in a dark place.
Application during pregnancy and lactation
Lipothioxone is contraindicated for women during pregnancy / lactation.
Pediatric use
Patients under 18 years of age are not prescribed Lipothioxone.
Drug interactions
- cisplatin: its effect is reduced;
- insulin and other oral hypoglycemic agents: the hypoglycemic effect is enhanced;
- glucose solution, Ringer's solution, compounds reacting with disulfide and SH-groups (including their solutions): incompatibility, since difficultly soluble complex compounds of α-lipoic acid are formed with sugar molecules.
Analogs
Lipothioxone analogs are: Thiolepta, Berlition 300, Thiolipon, Lipoic acid, Neurolipon, Espa-Lipon, Octolipen, Thioctic acid, Tiogamma, etc.
Terms and conditions of storage
Store in a place protected from light at a temperature of 15-25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Lipothioxone
Reviews of Lipothioxone are few. In some cases, experts note the development of side effects, most often in the form of hypoglycemia (for a dosage of 600 mg). There are also disorders of the digestive system and an increase in the level of liver enzymes.
The advantages usually include a convenient dosing regimen and an affordable cost.
Price for Lipothioxone in pharmacies
The approximate price for Lipothioxone (5 ampoules of 24 ml) is 773–853 rubles.
Lipothioxone: prices in online pharmacies
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Drug name Price Pharmacy |
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Lipothioxone 25 mg / ml concentrate for preparation of solution for infusion 12 ml 5 pcs. 339 r Buy |
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Lipothioxone conc. for prig solution for inf. 25mg / ml 12ml 5 pcs. 349 r Buy |
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Lipothioxone conc. for prig solution for inf. 25mg / ml 24ml 5 pcs. 727 RUB Buy |
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Lipothioxone 25 mg / ml concentrate for preparation of solution for infusion 24 ml 5 pcs. 727 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
