Legalon 70
Legalon 70: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Legalon 70
ATX code: A05BA03
Active ingredient: milk thistle fruit extract (Silybi mariani fructuum extract)
Manufacturer: Madaus, GmbH (Madaus, GmbH) (Germany)
Description and photo updated: 2019-29-07
Prices in pharmacies: from 248 rubles.
Buy
Legalon 70 is a drug of detoxification and hepatoprotective action.
Release form and composition
The preparation is produced in the form of capsules: size No. 2, hard, gelatinous, brown cap and body; the contents of the capsules are yellow powder (10 pcs. in a blister of aluminum foil and PVC film; in a cardboard box 2, 3 or 6 blisters and instructions for the use of Legalon 70).
1 capsule contains:
- active substance: dry extract of milk thistle fruit (36-44 ÷ 1) - 86.5-93.35 mg, equivalent of silymarin DNPH (dinitrophenylhydrazine) - 70 mg; silymarin HPLC (high performance liquid chromatography) / DAB 54.1 mg (eluent ethyl acetate) calculated as silibinin;
- additional components: sodium carboxymethyl starch (type A), mannitol, povidone, polysorbate 80, magnesium stearate;
- capsule shell: sodium lauryl sulfate, gelatin, titanium dioxide (E171), iron dyes red and black oxides (E172).
Pharmacological properties
Pharmacodynamics
Legalon 70 refers to hepatoprotective agents. The active substance of the drug, interacting with free radicals in the liver and converting them into compounds that are less toxic, interrupts the process of lipid peroxidation, preventing the destruction of cellular structures. The drug stimulates the production of functional and structural proteins, as well as phospholipids, in damaged liver cells (hepatocytes), as a result of specific stimulation of the RNA polymerase A enzyme. By stabilizing cell membranes, it prevents the loss of cell components - transaminases, increases the rate of liver cell regeneration. It inhibits the penetration into the cell of some substances toxic to the liver (in particular, the poison of the pale toadstool).
Pharmacokinetics
Silymarin is characterized by slow and low absorption, the half-absorption period is 2.2 hours. Metabolic transformation occurs through conjugation in the liver, the half-life is 6 hours. It is excreted mainly with bile in the form of sulfates and glucuronides, does not accumulate in the body. Intestinal-hepatic circulation is observed.
Indications for use
Legalon 70 is recommended for use for the treatment and prevention of toxic liver damage due to diseases / conditions such as:
- previous hepatitis of viral / toxic etiology, liver injury, surgery on the abdominal organs;
- chronic hepatitis, biliary dyskinesia, hepatocholecystitis, pancreatitis, liver cirrhosis;
- medicinal liver damage caused by the use of tetracycline, aminoglycosides, barbiturates, immunosuppressants, non-steroidal anti-inflammatory drugs (NSAIDs), anti-tuberculosis drugs, tranquilizers;
- toxic liver damage by organic solvents;
- poisoning with salts of heavy metals, mushrooms, halogenated hydrocarbons;
- alcohol intoxication;
- hyperlipidemia, atherosclerosis (prevention).
Contraindications
The use of the drug is contraindicated in case of hypersensitivity to any of its components.
Legalon 70, instructions for use: method and dosage
Legalon 70 capsules are taken orally after meals with a little water.
The recommended single therapeutic dose is 2 capsules, the maintenance dose is 1 capsule, with a frequency of administration 3 times a day.
Side effects
Allergic reactions may occur during treatment with the drug, in rare cases, a laxative effect may be observed.
Overdose
There is no data.
special instructions
There is no data.
Application during pregnancy and lactation
Pregnant and breastfeeding women are not recommended drug therapy.
Drug interactions
There are reports of the antagonistic interaction of silymarin with adrenergic blockers yohimbine and phentolamine.
Analogs
The analogues of Legalon 70 are Legalon 140, Silimar, Karsil, Forliver Help, Karsil Forte, Silibinin, etc.
Terms and conditions of storage
Store out of the reach of children, protected from light penetration, at a temperature not exceeding 30 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Legalon 70
The reviews on Legalon 70 found on medical websites are mostly positive. The drug is considered by many to be an effective natural and safe remedy for maintaining normal liver function. Patients note that after 1–2 months of treatment with the drug, pain, discomfort, unpleasant tingling and a feeling of heaviness in the right hypochondrium disappear. There are reports of the beneficial effects of Legalon 70 capsules on the digestive tract and pancreas. Many advise for the fastest recovery of the liver during therapy, strictly follow the recommended dosage regimen, give up alcohol and be sure to adhere to an appropriate diet.
The disadvantages of a hepatoprotective agent, some refer to its high cost and diarrhea that sometimes occurs during treatment. In some reviews, it is noted that an improvement in the condition was observed only during the course of treatment, and after its completion, all symptoms of liver damage appeared again.
Price for Legalon 70 in pharmacies
The price of Legalon 70, 70 mg capsules, can be 30 pcs per pack. - 260-310 rubles; per package 60 pcs. - 390-530 rubles.
Legalon 70: prices in online pharmacies
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Drug name Price Pharmacy |
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Legalon 70 70 mg capsules 30 pcs. 248 r Buy |
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Legalon 70 capsules 30 pcs. 328 RUB Buy |
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Legalon 70 70 mg capsules 60 pcs. 468 r Buy |
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Legalon 70 capsules 60 pcs. 664 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
