Levomethyl
Levometil: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Levometil
ATX code: D06C
Active ingredient: dioxomethyltetrahydropyrimidine + chloramphenicol (dioxomethyltetrahydropyrimidine + chloramphenicol)
Producer: GREEN OAK, CJSC (Russia)
Description and photo update: 2018-25-10
Prices in pharmacies: from 29 rubles.
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Levomethyl is a combined antimicrobial agent used to treat purulent wounds.
Release form and composition
Dosage form Levomethyl - ointment for external use: white with a yellowish tinge or white (in an aluminum tube 30 or 40 g, in a cardboard box 1 tube; in a polymer can 0.1; 0.5; 1; 1.5; 2; 2, 5; 3; 5; 10 or 20 kg - for medical institutions).
The composition of the ointment (in 100 g):
- active substances: chloramphenicol (chloramphenicol) - 0.75 g, dioxomethyltetrahydropyrimidine (methyluracil) - 4 g;
- auxiliary components: macrogol 400 (polyethylene oxide 400), macrogol 1500 (polyethylene oxide 1500).
Pharmacological properties
Pharmacodynamics
Levomethyl is a combined drug for external use that has antimicrobial and anti-inflammatory effects.
The active substance of Levomethyl - chloramphenicol - is an antibiotic. It inhibits the mechanism of protein synthesis of microorganisms, which determines its pronounced antimicrobial and bacteriostatic effect. Shows activity against a wide range of gram-positive and gram-negative bacteria (streptococci, staphylococci, intestinal and Pseudomonas aeruginosa and others). Chloramphenicol easily penetrates deep into tissues without damaging the biological membranes of cells. The antibacterial effect of the substance does not diminish in the presence of necrotic masses and pus.
Dioxomethyltetrahydropyrimidine normalizes the metabolism of nucleic acids, stimulates regeneration processes in wounds, the formation of granulation tissue, and epithelization of wounds. In addition, dioxomethyltetrahydropyrimidine has anti-inflammatory (dehydrating) effects.
Pharmacokinetics
A small amount of active substances penetrates into the general bloodstream. The drug has no systemic effect.
Indications for use
According to the instructions, Levomethyl is indicated for use in purulent wounds (including those infected with mixed microflora) in the first (purulent-necrotic) phase of the wound process.
Contraindications
Absolute:
- dermatitis, skin mycoses, psoriasis, eczema;
- increased individual sensitivity to any component of the drug.
Relative (the use of Levomethyl requires caution):
- pregnancy, lactation period;
- children's age up to 1 year.
Instructions for the use of Levometil: method and dosage
Levomethyl ointment is used externally.
A column of ointment 1 cm long and 5 mm in diameter weighs on average 0.3 g. This amount contains approximately 10 mg of chloramphenicol and 20 mg of dioxomethyltetrahydropyrimidine.
For adults and children over 1 year old, the drug is applied once a day directly to the damaged skin area at the rate of 0.3 g per 1 cm 2 of the wound surface, or applied to a sterile gauze napkin at the rate of 0.3-0.6 g per 1 cm 2 the wound surface, then cover the damaged area of the body with a napkin and apply a bandage to fix it. If the wound is deep, it is loosely filled with sterile gauze soaked in ointment. The drug is injected into the purulent cavity with a syringe through a drainage tube or catheter, preheating the ointment to 35–36 ° C.
It is recommended to dress once a day, every day, until the wound is completely cleared of pus and necrotic masses. The maximum daily dose of the ointment should not exceed the amount corresponding to 3 g of chloramphenicol.
The duration of the course of treatment with Levomethyl depends on the severity and course of the disease and is 5-14 days.
Side effects
During the period of application of Levometil, manifestations of allergic reactions in the form of urticaria, angioedema are possible. In this case, the use of the ointment is stopped and antihistamines are prescribed.
Overdose
Due to the poor absorption of the drug, overdose is unlikely.
If Levomethyl ointment is applied for a long time and to large areas of the skin, symptoms from the hematopoietic system may occur: leukopenia, anemia, reticulocytopenia, thrombocytopenia, which usually disappear after discontinuation of the drug and symptomatic treatment.
special instructions
When applying the ointment to large surfaces of the body and with long courses of therapy, it is recommended to conduct a clinical blood test.
Application during pregnancy and lactation
Levomethyl can be used during pregnancy and breastfeeding only when the expected benefit to the woman is higher than the likely risk to the fetus / child.
Pediatric use
Children under 1 year of age should be prescribed the drug with caution.
Drug interactions
When chloramphenicol is used together with topical dosage forms of lincomycin, clindamycin, gentamycin and erythromycin, a mutual weakening of the effect is possible.
Analogs
The analogues of Levometil are Levomekol and Levomikon-TFF.
Terms and conditions of storage
Store in a dark, dry place at a temperature of 12-15 ° C.
Keep out of the reach of children.
Shelf life - 3 years 6 months.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Levometil
Reviews of Levometil are positive. Ointment for various skin lesions helps to avoid inflammation, suppuration and promotes rapid healing. It works well for purulent wounds. The drug is also in demand because it is consumed very economically and has a low cost.
The price of Levometil in pharmacies
Approximate prices for Levometil for a 30 g tube are 25–40 rubles, for a 40 g tube - 35–50 rubles.
Levometil: prices in online pharmacies
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Drug name Price Pharmacy |
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Levomethyl ointment for external use 30 g 1 pc. RUB 29 Buy |
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Levomethyl ointment for external use 40 g 1 pc. RUB 36 Buy |
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Levomethyl ointment for outside. approx. tube 40g RUB 53 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
