Levokarnil Evalar - Instructions For Use, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Levocarnil

Levokarnil: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Levokarnil

ATX code: A16AA01

Active ingredient: levocarnitine (levocarnitine)

Manufacturer: CJSC "Evalar" (Russia)

Description and photo update: 2019-08-07

Prices in pharmacies: from 343 rubles.

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Levocarnil Evalar is a metabolic agent.

Release form and composition

Dosage form - solution for oral administration: clear, colorless or almost colorless liquid with a specific odor (50 and 100 ml each in brown / orange glass bottles, sealed with dropper stoppers and screw caps with first opening control, in a cardboard box 1 bottle together with instructions for use of Levocarnil and a measuring cup or without).

Composition of 1 ml solution:

• active substance: levocarnitine - 300 mg;
• auxiliary components: purified water, methyl parahydroxybenzoate, propyl parahydroxybenzoate, citric acid monohydrate.

Pharmacological properties

Pharmacodynamics

L-Carnitine is a naturally occurring substance related to the B vitamins.

Participates in metabolic processes as a carrier of long-chain fatty acids (including palmitic acid) from the cytoplasm to mitochondria, where they undergo β-oxidation with the formation of acetyl-CoA and adenosine triphosphoric acid.

Increases the secretion and enzymatic activity of gastric and intestinal juices, improves the absorption of food, fat and protein metabolism, reduces muscle fat, reduces excess body weight.

Reduces the degree of lactic acidosis, inhibits anaerobic glycolysis and the formation of keto acids. Promotes economical use of glycogen, increases its reserves in muscles and liver. Increases resistance to physical stress.

It has lipolytic and anabolic effects. Improves tissue energy supply and metabolism.

In hyperthyroidism, it normalizes an increased basal metabolism: it is a peripheral antagonist of the action of thyroid hormones, and not a direct inhibitor of thyroid function.

Pharmacokinetics

After oral administration, levocarnitine is well absorbed in the gastrointestinal tract. The maximum concentration is reached within 3 hours and remains in the therapeutic range for 9 hours. The drug easily penetrates into the myocardium and liver, more slowly into the muscles.

It is excreted from the body by the kidneys, mainly in the form of acyl esters.

Indications for use

Levocarnil is used as part of complex therapy in the following cases:

• diseases accompanied by a lack of carnitine or its intense loss, such as mitochondrial diseases, cardiomyopathies, myopathies, hereditary diseases with concomitant mitochondrial insufficiency (to replenish the deficiency of carnitine);
• anorexia nervosa syndrome;
• neurological manifestations in vascular, traumatic and toxic brain lesions;
• mild hyperthyroidism;
• skin diseases such as focal scleroderma, seborrheic eczema, psoriasis, discoid lupus erythematosus;
• chronic gastritis, chronic pancreatitis with reduced secretory function;
• the rehabilitation period after diseases, injuries and surgical interventions (including to accelerate tissue regeneration);
• psychoemotional stress, including in the elderly, and intense physical activity (to reduce fatigue, increase stamina and performance).

In addition, Levocarnil is used in adults with intense training and in sports medicine (during the training process when working out aerobic performance) in order to reduce body fat mass, increase muscle mass, improve coordination of movements and speed-strength indicators, accelerate muscle regeneration in traumatic injuries and for the prevention of post-workout syndrome (acceleration of recovery processes after physical exertion), as well as in pediatric practice when nursing newborns who have undergone asphyxia or birth trauma, and premature babies, low body weight gain and sluggish sucking reflex, reduced muscle tone, insufficient development of mental and motor functions (including for the prevention of these disorders in children at risk),underweight and growth retardation in children under 16 years of age.

Contraindications

Levocarnil solution is contraindicated in case of individual intolerance to its components.

It is not recommended to use the drug during pregnancy and lactation.

Levocarnil, instructions for use: method and dosage

Levocarnil is used as part of complex therapy. The solution should be taken orally after dilution with liquid, 30 minutes before meals. To improve the taste, the drug can be added to sweet drinks (compote, juices, jelly).

For ease of dispensing, you can use the included measuring cup, medical syringe or pipette.

Recommended dosage regimens of Levocarnil, depending on the indications:

• diseases accompanied by a lack of carnitine (primary and secondary carnitine deficiency): 50-100 mg / kg (2-5 drops / kg of body weight) 2-3 times a day for 3-4 months;
• anorexia nervosa syndrome, the rehabilitation period after past illnesses, injuries and surgical interventions: 1500 mg (5 ml) 2 times a day for 1-2 months;
• neurological manifestations in vascular, traumatic and toxic brain lesions: 750 mg (2.5 ml) per day for 3-5 days. If necessary, the course is repeated after a break of 12-14 days;
• hyperthyroidism mild: 250 mg (13 drops) 2-3 times a day for 20 days with a repetition of the course after 1-2 months or for 3 months continuously;
• skin diseases: 750 mg (2.5 ml) for 2-4 weeks;
• chronic gastritis, chronic pancreatitis with reduced secretory function: 375 mg (1.25 ml) 2 times a day for 1–1.5 months;
• long-term psycho-emotional and physical activity: depending on the severity of the condition, the dose of Levocarnil can vary from 750 mg (2.5 ml) 3 times a day to 2250 mg (7.5 ml) 2-3 times a day;
• intensive training and sports medicine: 2500 mg (8.33 ml) 1-3 times a day. When prescribing Levocarnil for therapeutic purposes, the daily dose is 70-100 mg / kg (5000-7500 mg per day). Duration of admission in the pre-competition period is 3-4 weeks, during the training process - up to 6-8 weeks.

Dosage of Levocarnil for children:

• up to 3 years: the dose is determined by the doctor individually;
• 3-6 years: 100 mg (5 drops) 2-3 times a day. The course of therapy is 1 month;
• 6-12 years: 200-300 mg 2-3 times a day for at least 1 month;
• with growth retardation: 250 mg (13 drops) 2-3 times a day for 20 days with a repetition of the course after 1-2 months or for 3 months continuously.

Side effects

• from the gastrointestinal tract: dyspeptic disorders, gastralgia;
• allergic reactions;
• others: myasthenia gravis (in patients with uremia).

Overdose

In case of an overdose of Levocarnil, dyspeptic disorders are observed, in patients with uremia - myasthenic disorders.

It is recommended to do a gastric lavage and take activated charcoal.

special instructions

Treatment of children under 3 years of age should be carried out under the close supervision of the attending physician.

Influence on the ability to drive vehicles and complex mechanisms

Levocarnil does not interfere with concentration and speed of reactions, therefore it does not affect the ability to drive vehicles and perform potentially hazardous activities that require special attention and speed of reactions.

Application during pregnancy and lactation

During pregnancy and lactation, the use of Levocarnil is not recommended, since studies on its effectiveness and safety have not been conducted during these periods.

Pediatric use

Levocarnil solution is used in pediatric practice according to indications.

With impaired renal function

No information available.

For violations of liver function

No information available.

Use in the elderly

A change in the dosage regimen of Levocarnil for elderly patients is not required.

Drug interactions

With the simultaneous use of glucocorticosteroids, there is an accumulation of levocarnitine in tissues (except for the liver).

Other anabolic steroids enhance the effect of Levocarnil.

Analogs

Analogues of Levocarnil are: Angiocardil, Berlition 300, Berlition 600, Vasomag, Glycine, Glycine Bio, Glycine Forte, Dibikor, Inosie-F, Potassium orotat, Cardionat, Carnitine, Corylip, Limontar, Meldonium, Methionine, Mildrinatoxin, Neo, Thiogamma, Cytoflavin, Elkar, Espa-Lipon, etc.

Terms and conditions of storage

Store at a temperature not exceeding 25 ° C out of reach of children.

The shelf life is 3 years.

After opening, the bottle should be stored in the refrigerator for no more than 2 months.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Levokarnil

Reviews about Levocarnil are most often left by persons who take it for weight loss and sports. According to patients, this tool is an excellent assistant in sports training: it increases endurance and resistance to physical activity, accelerates the process of burning fat. According to reviews, the drug is well tolerated without causing the development of side effects. The taste of the solution is described mainly as not very pleasant, but when diluted with water or juice, there is no sugaryness.

The price of Levocarnil in pharmacies

The average price for Levocarnil Evalar for 1 bottle of 100 ml is 515 rubles.

Levocarnil: prices in online pharmacies

Drug name Price Pharmacy

Levocarnil 500 mg tablets 30 pcs. 343 r Buy

Levocarnil 500mg tab 1.2g 30 pcs. 424 r Buy

Levokarnil solution for internal approx. 300 mg / ml vial 100ml 431 r Buy

Levocarnil 300 mg / ml oral solution 100 ml 1 pc. 432 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!