Ibuprofen-Hemofarm - Instructions For Use, Tablets 400 Mg, Price

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Ibuprofen-Hemofarm

Ibuprofen-Hemofarm: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Ibuprofen-Hemopharm

ATX code: M01AE01

Active ingredient: ibuprofen (ibuprofen)

Manufacturer: HEMOFARM A. D. (Serbia)

Description and photo update: 2018-21-11

Prices in pharmacies: from 66 rubles.

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Ibuprofen-Hemofarm is a non-steroidal anti-inflammatory drug (NSAID).

Release form and composition

Dosage forms of Ibuprofen-Hemofarm:

• effervescent tablets: round, flat-cylindrical, from yellowish-white to white, beveled on both sides, with a slight lemon scent (10 or 20 pcs. in plastic tubes, 1 or 2 tubes in a cardboard box);
• film-coated tablets: round, biconvex, from yellowish-white to white, with a dividing line on one side, the core of the tablet is from yellowish-white to white (10 pcs. in blisters, in a cardboard box 1, 2, 3 or 5 blisters).

1 effervescent tablet contains:

• active substance: ibuprofen D, L-lysinate - 0.342 g, this is equivalent to 0.2 g of ibuprofen;
• auxiliary components: xylitol, sodium carbonate, aspartame, sodium saccharinate, povidone K-25, simethicone aqueous emulsion (Silfar SE-4), lemon flavor.

1 film-coated tablet contains:

• active substance: ibuprofen - 0.4 g;
• auxiliary components: microcrystalline cellulose PH101, stearic acid, colloidal anhydrous silicon dioxide, sodium carboxymethyl starch;
• composition of the film shell: polysorbate 80, copolymer of ethacrylate and methacrylic acid (1: 1), titanium dioxide (E171), talc.

Pharmacological properties

Pharmacodynamics

Ibuprofen-Hemofarm has analgesic, anti-inflammatory, antipyretic activity. The active substance is ibuprofen, its mechanism of action is due to inhibition of the synthesis of prostaglandins - mediators of inflammation, pain and hyperthermic reaction and indiscriminate blocking of cyclooxygenase 1 and 2. The manifestation of the therapeutic effect of the drug is the weakening of pain syndrome (including joint pain at rest and during movement), an increase in the range of motion, reduction of morning stiffness and swelling of the joints.

Pharmacokinetics

Ibuprofen is absorbed quickly, its maximum concentration (C _max) in blood plasma when taken on an empty stomach is reached after 0.75 hours. Taking the drug after meals causes a slight decrease in the rate of absorption, C _{max is} achieved in 1.5–2.5 hours. After 2-3 hours, the concentration of ibuprofen in the synovial fluid is higher than in the blood plasma.

Plasma protein binding - 90%.

Ibuprofen penetrates into the joint cavity slowly, lingering in the synovial tissue.

The biological activity of ibuprofen is associated with the S-enantiomer. Approximately 60% of the pharmacologically inactive R-form after absorption is slowly converted to the active S-form. Metabolized by the isoenzyme CYP2C9. The pre-systemic and post-systemic metabolism of the drug occurs in the liver.

The half-life (T _1/2) with biphasic elimination kinetics is 2–2.5 hours.

In the form of metabolites (unchanged - up to 1% ibuprofen), it is excreted to a greater extent through the kidneys, a small part - with bile.

Pharmacokinetic parameters do not change in elderly patients.

Indications for use

• symptomatic therapy of inflammatory and degenerative diseases of the musculoskeletal system, including osteoarthritis, rheumatoid arthritis, juvenile chronic arthritis, psoriatic arthritis, gouty arthritis, ankylosing spondylitis (ankylosing spondylitis) - to reduce pain and reduce inflammation during use (the drug has no effect on disease progression);
• myalgia, ossalgia, arthritis, arthralgia, sciatica, neuralgia, tendovaginitis, tendonitis, bursitis, headache (including menstrual syndrome), migraine, toothache accompanied by inflammation post-traumatic and postoperative condition, oncological pathologies - as a pain reliever;
• algodismenorrhea, adnexitis and other inflammatory processes in the small pelvis;
• colds and infectious diseases, accompanied by febrile syndrome.

Contraindications

• acute period of gastric ulcer and duodenal ulcer, peptic ulcer, ulcerative colitis, ulcerative colitis, Crohn's disease and other erosive and ulcerative pathologies of the gastrointestinal tract (gastrointestinal tract), gastrointestinal bleeding, inflammatory bowel disease;
• incomplete or complete combination of bronchial asthma, recurrent polyposis of the paranasal sinuses and nose, intolerance to acetylsalicylic acid or other NSAIDs (including history);
• bleeding disorder (including a tendency to bleeding, prolonged bleeding time, hemophilia, hypocoagulation, hemorrhagic diathesis);
• intracranial hemorrhage;
• period after coronary artery bypass grafting;
• severe stage of renal failure [creatinine clearance (CC) less than 30 ml / min], progressive kidney disease, confirmed hyperkalemia;
• severe liver failure, active liver disease;
• III trimester of pregnancy;
• age up to 6 years - for effervescent tablets (0.2 g);
• age up to 12 years - for film-coated tablets (0.4 g);
• individual intolerance to acetylsalicylic acid and other NSAIDs;
• hypersensitivity to the components of the drug.

It is recommended to take Ibuprofen-Hemofarm with caution in patients with hepatic failure, hyperbilirubinemia, liver cirrhosis with portal hypertension, renal failure (CC less than 60 ml / min), nephrotic syndrome, chronic heart failure, arterial hypertension, ischemic heart disease, peripheral arterial disease, cerebral diseases, dyslipidemia or hyperlipidemia, diabetes mellitus, a history of gastric ulcer and duodenal ulcer, with gastritis, the presence of Helicobacter pylori infection, colitis, enteritis, blood diseases of unknown etiology (anemia, leukopenia), long-term use of NSAIDs, severe somatic diseases, smoking, frequent alcohol consumption, breastfeeding, in the I and II trimesters of pregnancy,in old age.

In addition, caution should be exercised with concomitant therapy with antiplatelet agents (including acetylsalicylic acid, clopidogrel), prednisolone and other oral glucocorticosteroids (GCS), selective serotonin reuptake inhibitors (including fluoxetine, paroxetine, citalopram, sertralin) (including anticoagulants) (including anticoagulants).

Instructions for use of Ibuprofen-Hemofarm: method and dosage

Effervescent tablets

Ibuprofen-Hemofarm 200 mg Effervescent Tablets must not be swallowed whole, chewed or sucked.

The tablets are taken orally, after being dissolved in 200 ml of water, after meals.

The dose of the drug is selected individually, taking into account clinical indications.

To achieve the desired therapeutic effect, Ibuprofen-Hemofarm should be taken in the lowest effective dose.

Recommended dosage for patients over 6 years old:

• children 6-12 years old: 1 pc. (0.2 g) 2–4 times a day at intervals of 4–6 hours. The maximum daily dose is 4 pcs. (0.8 g);
• children over the age of 12: 1–2 pcs. (0.2-0.4 g) every 4-6 hours. The maximum daily dose is 5 pcs. (1 g);
• adults: 1–2 pcs. (0.2-0.4 g) every 4-6 hours. The daily dose should not exceed 6 pcs. (1.2 g).

You can continue to use the tablets for 2-3 days. In the absence of a therapeutic effect, you must consult a doctor.

Film-coated tablets

Ibuprofen-Hemofarm 400 mg tablets are taken orally after meals, swallowing whole and drinking plenty of water.

The dose should be selected individually, taking into account clinical indications, using the smallest effective dose that will ensure the desired therapeutic effect.

Recommended dosage for patients over 12 years old: 1 pc. (0.4 g) with an interval of at least 4 hours. Maximum daily dose: adults - 3 pcs. (1.2 g), children 12-18 years old - 2.5 pcs. (1 d).

If after 2–3 days of treatment the symptoms of the disease persist, you must stop taking Ibuprofen-Hemofarm and consult a doctor.

Side effects

• from the digestive system: non-steroidal gastropathy (heartburn, nausea, vomiting, abdominal pain, loss of appetite, flatulence, constipation, diarrhea, epigastric discomfort and pain); rarely - dryness of the oral mucosa, irritation, ulceration of the gingival mucosa, pain in the mouth, aphthous stomatitis, ulceration of the gastrointestinal tract mucosa, perforation and / or bleeding of the gastrointestinal tract, hepatitis, pancreatitis;
• on the part of the cardiovascular system: increased blood pressure (BP), tachycardia, heart failure;
• from the nervous system: insomnia, anxiety, headache, dizziness, drowsiness, nervousness, psychomotor agitation, irritability, hallucinations, confusion, depression; rarely - aseptic meningitis (more often against the background of autoimmune pathologies);
• on the part of the sensory organs: dryness and / or irritation of the eyes, toxic optic neuritis (reversible), blurred vision (diplopia), edema of allergic genesis of the conjunctiva and eyelids, scotoma, noise or ringing in the ears, hearing loss;
• from the respiratory system: bronchospasm, shortness of breath;
• from the urinary system: allergic nephritis, acute renal failure, cystitis, polyuria, edema (nephrotic syndrome);
• on the part of the hematopoietic organs: anemia (including hemolytic anemia, aplastic anemia), agranulocytosis, leukopenia, thrombocytopenia, thrombocytopenic purpura;
• allergic reactions: erythematous skin rash, urticaria, pruritus, allergic rhinitis, bronchospasm, fever, angioneurotic edema, exudative erythema multiforme (including Stevens-Johnson syndrome), anaphylactoid reactions, eosinophilia, Lyell's anaphylactic syndrome;
• others: increased sweating.

Overdose

Symptoms: nausea, vomiting, abdominal pain, drowsiness, lethargy, depression, tinnitus, headache, low blood pressure, tachycardia, bradycardia, atrial fibrillation, metabolic acidosis, acute renal failure, coma, respiratory arrest.

Treatment: gastric lavage within the first hour after taking a high dose of ibuprofen. Reception of activated carbon, forced diuresis, alkaline drinking. Symptomatic therapy, including correction of blood pressure, acid-base state.

special instructions

Treatment with the drug requires monitoring of the peripheral blood picture, the functional state of the kidneys and liver.

During the period of therapy, the use of alcohol and the use of ethanol-containing drugs are contraindicated.

Long-term use of high doses of Ibuprofen-Hemofarm increases the risk of ulceration on the gastrointestinal tract mucosa, the development of gastrointestinal, uterine, hemorrhoidal bleeding, bleeding gums, visual disturbances (scotoma, color vision, amblyopia). To avoid the development of severe side effects from the gastrointestinal tract, it is necessary to apply the minimum effective dose for a short course of treatment.

When signs of gastropathy appear, the patient's condition should be carefully monitored. It is shown carrying out esophagogastroduodenoscopy, analysis of feces for occult blood, laboratory blood tests to determine the level of hemoglobin and hematocrit.

To prevent the development of non-steroidal gastropathy, Ibuprofen-Hemofarm is recommended to be combined with prostaglandins (misoprostol).

The use of ibuprofen should be discontinued 48 hours before studies to determine 17-ketosteroids.

Influence on the ability to drive vehicles and complex mechanisms

During the period of ibuprofen use, patients should abandon potentially hazardous activities, the implementation of which requires increased attention, high speed of psychomotor reactions, including driving.

Application during pregnancy and lactation

The use of ibuprofen in the third trimester of pregnancy is contraindicated.

It is possible to use Ibuprofen-Hemofarm with caution in the first and second trimesters of the gestation period and during lactation.

Pediatric use

Effervescent tablets 200 mg are contraindicated for the treatment of children under the age of 6 years.

Ibuprofen-Hemofarm 400 mg film-coated tablets should not be taken by children under 12 years of age.

With impaired renal function

According to the instructions, Ibuprofen-Hemofarm is contraindicated in patients with progressive kidney disease, severe renal failure (CC less than 30 ml / min), confirmed by hyperkalemia.

With care: nephrotic syndrome, renal failure (CC less than 60 ml / min).

For violations of liver function

The use of the drug Ibuprofen-Hemofarm is contraindicated in patients with severe hepatic failure, active phase of liver disease.

It is recommended to take pills with caution to patients with hepatic insufficiency, liver cirrhosis with portal hypertension, hyperbilirubinemia.

Use in the elderly

In old age, Ibuprofen-Hemofarm should be used with caution.

Drug interactions

With the simultaneous use of the drug Ibuprofen-Hemofarm:

• acetylsalicylic acid lowers its anti-inflammatory and antiplatelet effect (the risk of acute coronary insufficiency increases in patients who take small doses of acetylsalicylic acid as antiplatelet agents);
• anticoagulants, thrombolytic agents (alteplase, urokinase, streptokinase) increase the risk of bleeding;
• ethanol, phenytoin, barbiturates, phenylbutazone, rifampicin, tricyclic antidepressants (inducers of microsomal oxidation) cause an increase in the production of hydroxylated active metabolites, which increases the risk of developing severe hepatotoxic conditions;
• fluoxetine, citalopram, paroxetine, sertraline (serotonin reuptake inhibitors) contribute to the development of gastrointestinal bleeding, including significant;
• cefotetan, cefamandol, cefoperazone, plikamycin, valproic acid cause an increase in the incidence of hypoprothrombinemia;
• insulin, oral hypoglycemic agents, including sulfonylurea derivatives, enhance their effect;
• gold preparations, cyclosporine enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, causing an increase in nephrotoxicity; cyclosporine increases its plasma concentration and the risk of developing hepatotoxic effects;
• inhibitors of microsomal oxidation reduce the likelihood of hepatotoxic effects;
• cholestyramine, antacids help to reduce the absorption of ibuprofen;
• slow calcium rope blockers, angiotensin-converting enzyme inhibitors (vasodilators) reduce their hypotensive activity;
• agents that block tubular secretion, increase the plasma concentration of ibuprofen;
• uricosuric agents reduce their therapeutic efficacy;
• furosemide, hydrochlorothiazide reduce natriuretic and diuretic effects;
• indirect anticoagulants, antiplatelet agents, fibrinolytics enhance their effect;
• mineralocorticosteroids, glucocorticosteroids, ethanol, colchicine, estrogens enhance their ulcerogenic effect, increasing the risk of bleeding;
• caffeine enhances the analgesic effect of ibuprofen;
• digoxin, lithium preparations, methotrexate increase their level of concentration in the blood;
• myelotoxic drugs cause an increase in the hematotoxic manifestations of the drug.

It is not recommended to use other NSAIDs together with ibuprofen.

Analogs

Ibuprofen-Hemofarm analogs are: Advil, Nurofen, MIG 400, Faspik, Solpaflex, Ibuprom.

Terms and conditions of storage

Keep out of the reach of children.

Store at a temperature of 15-25 ° C, protected from moisture.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Ibuprofen-Hemofarm

Reviews about Ibuprofen-Hemofarm are mostly positive. The therapeutic versatility of the drug allows it to be used as a pain reliever for pain syndromes of various origins. Patients indicate a quick and effective action in algodismenorrhea, exacerbation of osteochondrosis, arthritis, radiculitis, headache and toothache. The antipyretic effect of the drug in acute respiratory infections and influenza is noted.

The advantages of the drug include the possibility of its use as an anti-inflammatory and analgesic agent during lactation in women after a cesarean section.

Given the rather wide list of contraindications and side effects, without a doctor's prescription, patients recommend taking Ibuprofen-Hemofarm for a short time and in strict accordance with the dosage regimen attached to the instructions.

Price for Ibuprofen-Hemofarm in pharmacies

The price of Ibuprofen-Hemofarm for a package containing 30 film-coated tablets can range from 75 rubles.

Ibuprofen-Hemofarm: prices in online pharmacies

Drug name Price Pharmacy

Ibuprofen-Hemofarm 400 mg film-coated tablets 30 pcs. RUB 66 Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!