Detraven
Detraven: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Detraven
ATX code: C05CA53
Active ingredient: hesperidin (Hesperidinum) + diosmin (Diosminum)
Manufacturer: JSC "Borisov Plant of Medical Products" (JSC "BZMP") (Republic of Belarus)
Description and photo update: 2019-09-07
Detraven is a herbal medicine (bioflavonoid) that reduces capillary permeability.
Release form and composition
Dosage form - film-coated tablets: biconvex, oval, pink shell (10 tablets in blister packs, 3 or 6 packs in a carton; 5 tablets in blisters, 6 or 12 packs in a carton and instructions for application of Detraven).
Composition of 1 tablet:
- active substance: a mixture of diosmin and hesperidin (in a ratio of 9 ÷ 1) - 500 mg (in terms of the total content of flavonoids);
- auxiliary components: gelatin, talc, magnesium stearate, sodium salt of carboxymethylated starch, microcrystalline cellulose, Opadry 200 F (partially hydrolyzed polyvinyl alcohol, titanium dioxide, talc, Macrogol 3350, methacrylic acid copolymer type C, sodium bicarbonate black and yellow gland).
Pharmacological properties
Pharmacodynamics
Detraven has a venotonic and angioprotective effect.
The main effects of the drug:
- reduction of vein distensibility and venous stasis;
- increasing the resistance of capillaries and reducing their permeability;
- increased lymphatic drainage;
- improved lymphatic drainage.
The optimal ratio of effect and dose is observed when using 2 tablets per day. The therapeutic efficacy of Detraven has been proven in the treatment of organic and functional chronic venous insufficiency of the lower extremities, as well as hemorrhoids.
Pharmacokinetics
The composition of Detraven tablets includes a purified flavonoid fraction of hesperidin and diosmin in micronized form, i.e., the size of the particles of the active substance is reduced, due to this, their active absorption and a faster onset of action are ensured.
Diosmin in the gastrointestinal tract is rapidly processed by the intestinal (parietal) microflora and absorbed into the blood in the form of aglycone - diosmethine, which is soluble in lipids. The forms of diosmin that remain unprocessed are not absorbed in the body.
The redistribution of matter by blood through tissues occurs very quickly. Animal experiments using radiolabeled diosmin show that its metabolites are widely distributed throughout the body. The maximum concentration of diosmethine in the blood is reached within 1-3 hours after oral administration of Detraven.
The drug undergoes extensive metabolism, this is confirmed by the presence of various phenolic acids in the urine. Excretion is carried out mainly with feces; an average of 14% of the dose is excreted in the urine. The half-life is 11 hours.
Indications for use
Detraven is prescribed concurrently with other medicines to treat the following symptoms:
- venous lymphatic insufficiency, in the form of heaviness, pain and swelling in the legs, trophic disorders;
- conditions associated with an acute attack of hemorrhoids.
Contraindications
- lactation period;
- age up to 18 years;
- individual intolerance to the components of the drug.
Detraven, instructions for use: method and dosage
Detraven tablets are taken orally, with meals.
Recommended dosage regimen:
- venous insufficiency: 2 tablets per day (afternoon and evening);
- acute hemorrhoids: in the first four days of therapy - 3 tablets in the morning and in the evening, in the next three days, a single dose is reduced to 2 tablets.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- digestive system: often - dyspepsia, vomiting, diarrhea, nausea; infrequently - colitis;
- nervous system: rarely - general malaise, dizziness, headache;
- skin and subcutaneous tissue: rarely - urticaria, rash, itching; with an unknown frequency - isolated edema of the eyelids, lips, face; in exceptional cases - angioedema.
Overdose
There are no reports of overdose cases.
special instructions
Taking Detraven against the background of acute attacks of hemorrhoids should be carried out in a short course, it does not replace special treatment. If symptoms persist quickly, proctologic examination should be performed and therapy reviewed.
For disorders that affect venous circulation, the best results from Detraven are observed in patients who adhere to a healthy lifestyle. Prolonged sun exposure, weight gain, and prolonged standing should be avoided. Walking is beneficial for improving blood circulation.
Patients must strictly adhere to the additional therapeutic measures prescribed by the doctor, including a cool shower, compresses on the lower extremities, wearing medical compression hosiery (stockings, knee-highs), etc.
Application during pregnancy and lactation
- pregnancy: there is no information confirming or refuting the safety of the drug; according to numerous studies, the teratogenic effect and undesirable effects have not been identified with the use of Detraven;
- feeding period: breastfeeding is recommended to be canceled, since there is no data on the excretion of the drug into breast milk.
Pediatric use
For patients under 18 years of age, the drug is not prescribed.
Drug interactions
Studies on the interaction of Detraven with other drugs have not been conducted. Given the extensive post-marketing experience with similar drugs, no interactions have been reported.
Analogs
Detraven's analogues are Hesperidin + Diosmin, Venolife Dio, Angiorus, Venarus, DioridinVel, Detravenol, Diovenges, Stimulven, Detralex, Flebaven, Venosmin, etc.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 30 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Detraven
Reviews about Detraven are quite rare, but most of them indicate the high effectiveness of the drug.
Patients mention side effects in isolated cases.
Price for Detraven in pharmacies
The price of Detraven is unknown, since the drug is not available in pharmacies.
The approximate cost of analogues: Detralex (60 tablets 1000 mg each) - 2604 rubles; Flebaven (64 tablets of 500 mg) - 905 rubles; Venarus (60 tablets 1000 mg each) - 1723 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
