Supraks Solutab
Supraks Solutab: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Suprax
ATX code: J01DD08
Active ingredient: Cefixim
Producer: Menarini Manufecuring Logis (Italy)
Description and photo update: 19.10.2018
Prices in pharmacies: from 641 rubles.
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Suprax Solutab is an oral semi-synthetic antibiotic.
Release form and composition
The dosage form of the release is dispersible tablets: pale orange, oblong, on both sides with a risk, have a strawberry smell (1, 5 or 7 pcs. In blisters; in a cardboard box 1 or 2 blisters).
Composition of 1 tablet:
- active substance: cefixime - 400 mg (cefixime trihydrate - 447.7 mg);
- auxiliary components: calcium saccharinate trisquihydrate - 20 mg; colloidal silicon dioxide - 5 mg; magnesium stearate - 10 mg; microcrystalline cellulose - 44.5 mg; povidone - 5 mg; low-substituted hyprolosis - 40 mg; strawberry flavor PV4284 - 2.5 mg; strawberry flavor FA15757 - 5 mg; dye "sunset yellow" (E110) - 0.3 mg.
Pharmacological properties
Pharmacodynamics
Suprax Solutab belongs to the group of semi-synthetic antibiotics from the group of III generation cephalosporins for oral administration. It has a bactericidal effect, the mechanism of which is based on inhibition of the synthesis of bacterial cell walls. Cefixime is resistant to the action of a wide range of β-lactamases produced by various gram-negative and gram-positive bacteria.
The effectiveness of cefixime has been confirmed in infections associated with Proteus mirabilis, Escherichia coli, Neisseria gonorrhoeae, Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes, Moraxella catarrhalis.
Cefixime is also active against gram-positive and gram-negative bacteria, including Citrobacter diversus, Streptococcus agalactiae, Haemophilus parainfluenzae, Proteus vulgaris, Citrobacter amalonaticus, Shigella spp., Salmonella spp., Klebsiella multociidae, Pasteurella opp.
Listeria monocytogenes, Enterococcus spp., Pseudomonas spp., Most strains of Enterobacter spp., Staphylococcus spp. Are resistant to the drug. (including methicillin-resistant strains), Clostridium spp., Bacteroides fragilis.
Pharmacokinetics
The main characteristics of the active substance:
- absorption: oral bioavailability - 40-50%, it does not depend on food intake. The maximum plasma concentration of the substance in the blood after taking 400 mg of the drug is achieved after 3-4 hours and varies in the range of 2.5-4.9 μg / ml, after taking 200 mg - from 1.49 to 3.25 μg / ml. Food intake does not significantly affect the absorption of the drug from the gastrointestinal tract;
- distribution: with the introduction of 200 mg of cefixime, Vd is 6.7 liters, upon reaching Css - 16.8 liters; approximately 65% binds to plasma proteins. The highest concentrations of cefixime are recorded in bile and urine. The substance crosses the placenta. Its concentration in the blood of the umbilical cord reaches 1 / 6 - 1 / 2 concentration in plasma Supraksa Soljutab maternal blood; cefixime is not detected in breast milk;
- metabolism and excretion: the half-life is 3-4 hours, the substance is not metabolized in the liver; 50–55% of the dose taken is excreted unchanged in the urine within 24 hours, about 10% is excreted in the bile.
With renal failure, it is possible to increase the half-life and, accordingly, the plasma concentration of the drug and slow down its elimination by the kidneys. In patients with creatinine clearance of 30 ml / min, when 400 mg of cefixime is taken, the half-life increases to 7–8 hours, the plasma concentration of the substance averages 7.53 μg / ml, and excretion in the urine in 24 hours is 5.5%. With cirrhosis of the liver, the half-life is increased to 6.4 hours, the time to reach the plasma concentration of the substance is 5.2 hours; at the same time, the proportion of Suprax Solutab, eliminated by the kidneys, increases.
Indications for use
According to the instructions, Suprax Solutab is prescribed for the treatment of infectious and inflammatory diseases caused by microorganisms that are sensitive to its action:
- sinusitis;
- streptococcal tonsillitis and pharyngitis;
- exacerbation of chronic bronchitis;
- acute bronchitis;
- uncomplicated urinary tract infections;
- acute otitis media;
- shigellosis;
- uncomplicated gonorrhea.
Contraindications
Absolute:
- chronic renal failure in children;
- weight less than 25 kg;
- lactation period;
- individual intolerance to the components of the drug, as well as cephalosporins / penicillins.
Relative (diseases / conditions in the presence of which the appointment of cefixime requires caution):
- burdened history of colitis;
- renal failure;
- pregnancy;
- elderly age.
Instructions for the use of Suprax Solutab: method and dosage
Suprax Solutab is taken orally, regardless of food intake. The tablet can be swallowed whole with a sufficient amount of water or previously diluted in water (you need to drink the suspension immediately after preparation).
The daily dose for adults and children weighing 50 kg or more is 400 mg (can be divided into 2 parts), with a weight of 25-50 kg - 200 mg in 1 dose.
The duration of therapy is determined by the nature of the disease and the type of infection. After the symptoms of fever / infection have disappeared, it is advisable to continue treatment for 48–72 hours.
The recommended duration of use of Suprax Solutab tablets 400 mg:
- ENT and respiratory tract infections: 7-14 days;
- tonsillopharyngitis caused by Streptococcus pyogenes: at least 10 days;
- uncomplicated gonorrhea: 1 day;
- uncomplicated infections of the lower and upper urinary tract in men: 7-14 days;
- uncomplicated lower / upper urinary tract infections in women: 3 to 7-14 days.
In cases of impaired renal function, the dose is determined by creatinine clearance:
- 21-60 ml / min or patients on hemodialysis: decrease in the daily dose by 25% (it is recommended to use other dosage forms);
- ≤ 20 ml / min or patients on peritoneal dialysis: halve the daily dose.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- urinary system: very rarely - hematuria, a slight increase in the concentration of creatinine in the blood;
- hematopoietic system: very rarely - agranulocytosis, transient leukopenia, pancytopenia, eosinophilia or thrombocytopenia; in some cases - blood clotting disorders;
- digestive system: often - digestive disorders, abdominal pain, nausea, diarrhea and vomiting; rarely - a transient increase in the level of transaminases and alkaline phosphatase; very rarely - pseudomembranous colitis; in some cases - cholestatic jaundice and hepatitis;
- central nervous system: infrequently - dizziness, headaches, dysphoria;
- allergic reactions: rarely - pruritus, urticaria; very rarely - Lyell's syndrome (immediate withdrawal of Suprax Solutab is required), a syndrome resembling serum sickness, drug fever, interstitial nephritis and hemolytic anemia (in cases of anaphylactic shock, epinephrine, antihistamines and systemic glucocorticosteroids should be administered).
Overdose
The main symptoms: an increase in the frequency of dose-dependent adverse reactions.
Therapy: symptomatic and supportive; gastric lavage; peritoneal dialysis and hemodialysis are ineffective.
special instructions
In connection with the likelihood of developing cross-allergic reactions with penicillins, before the appointment of Suprax Solutab, the patient's history must be carefully evaluated. In cases of allergic reactions, the drug is immediately canceled.
With a long course, a violation of the normal intestinal microflora is possible. This can cause the overgrowth of Clostridium difficile and the development of pseudomembranous colitis. In cases of the appearance of mild forms of antibiotic-associated diarrhea, in most cases it is enough to stop taking Suprax Solutab. In more severe forms, it is recommended to carry out corrective therapy (for example, vancomycin orally 4 times a day, 250 mg). Antidiarrheal drugs that inhibit gastrointestinal motility are contraindicated in pseudomembranous colitis.
When combined with high doses of certain drugs, including polymyxin B, aminoglycosides, sodium colistimethate, loop diuretics (furosemide, ethacrynic acid), it is necessary to control renal function. After the end of long-term treatment, it is necessary to check the state of the hematopoiesis function.
Dissolve Suprax Solutab 400 mg tablets only in water.
During the course of the treatment course, when using some test systems for express diagnostics, a false positive urine reaction to glucose and a false positive direct Coombs' reaction are possible.
Influence on the ability to drive vehicles and complex mechanisms
Studies on the effect of cefixime on the ability to drive vehicles have not been conducted, therefore, it is necessary to take into account the likelihood of an individual reaction to the drug's action, including the development of dizziness.
Application during pregnancy and lactation
Before the appointment of Supraksa Solutab, pregnant women need to correlate the expected benefit with the possible risk.
Breastfeeding should be temporarily discontinued while using the drug.
Pediatric use
Weight less than 25 kg and chronic renal failure are contraindications to the use of Suprax Solutab in children.
With impaired renal function
In renal failure, the drug should be administered with caution and in reduced doses (depending on creatinine clearance).
Use in the elderly
Elderly patients should use the drug with caution.
Drug interactions
With the combined use of cefixime with certain drugs / substances, the following effects may develop:
- tubular secretion blockers, including probenecid: slowing down the excretion of cefixime in the urine, which can cause an overdose;
- carbamazepine: an increase in its plasma concentration (therapeutic drug monitoring is recommended);
- indirect anticoagulants: increasing their action and reducing the prothrombin index.
Analogs
The analogues of Suprax Solutab are: Ixim Lupine, Pantsef, Tsemidexor, Supraks.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Supraks Solutab
According to reviews, Suprax Solutab is a fairly effective drug when used for cystitis and sinusitis. The development of adverse reactions has been reported in rare cases.
The price of Suprax Solutab in pharmacies
The approximate price for Suprax Solutab (7 pcs in a package) is 750-830 rubles.
Suprax Solutab: prices in online pharmacies
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Drug name Price Pharmacy |
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Suprax Solutab 400 mg dispersible tablets 7 pcs. 641 r Buy |
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Suprax Solutab dispersion tablets 400mg 7 pcs. 839 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
