Bromhexin-Akrikhin - Instructions For The Use Of Syrup, Tablets, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Bromhexine-Akrikhin

Bromhexin-Akrikhin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Bromhexine-Akrichin

ATX code: R05CB02

Active ingredient: bromhexine (bromhexine)

Manufacturer: JSC "Akrikhin" (Russia)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 39 rubles.

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Bromhexine-Akrikhin is an expectorant mucolytic drug.

Release form and composition

Dosage forms of the drug:

• syrup: a clear liquid from light yellow to yellow with a greenish tinge, with a characteristic odor (100 ml in a bottle, in a cardboard box 1 bottle with a measuring spoon or glass);
• tablets: flat-cylindrical, white, yellowish or grayish tint is allowed, with a chamfer [10 tablets in a blister strip, in a cardboard box 2 (for 8 mg tablets) or 5 (for 4 mg tablets) packages].

Composition of 100 ml of Bromhexin-Akrikhin syrup:

• active substance: bromhexine hydrochloride (in terms of 100% substance) - 80 mg;
• auxiliary components: propylene glycol, benzoic acid, sorbitol, levomenthol, citric acid monohydrate, sodium saccharinate dihydrate, vanillin, dye, orange flavor, purified water.

Composition of 1 tablet Bromhexin-Akrikhin:

• active substance: bromhexine hydrochloride (in terms of 100% substance) - 4 or 8 mg;
• auxiliary components: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, calcium stearate.

Pharmacological properties

Pharmacodynamics

Bromhexine is a mucolytic (secretolytic) agent, has an expectorant and weak antitussive effects. Reduces the viscosity of sputum due to depolymerization of mucoprotein and mucopolysaccharide fibers and an increase in the serous component in bronchial secretions. In addition, the drug activates the ciliated epithelium, increases the volume of sputum and improves its discharge. It has a stimulating effect on endogenous surfactant (increases its production), which is necessary for the stability of alveolar cells during respiration. The effect of the drug develops on days 2–5 of therapy.

Pharmacokinetics

When bromhexine is taken orally within 30 minutes, it is absorbed almost completely (99%). About 80% of the dose taken is metabolized by the first pass effect through the liver. Bromhexine crosses the placental and blood-brain barriers. After demethylation and oxidation of bromhexine, the active metabolite ambroxol is formed in the liver. The substance is characterized by slow reverse diffusion from tissues, due to which its half-life is 15 hours. It is excreted by the kidneys. Chronic renal failure can interfere with the elimination process. With repeated administration of the drug, there is a risk of its cumulation.

Indications for use

Diseases accompanied by difficulty in the discharge of viscous sputum:

• bronchitis (of various etiology, including with bronchiectasis);
• tracheobronchitis;
• bronchial asthma;
• pulmonary tuberculosis;
• pneumonia;
• cystic fibrosis;
• preoperative period and carrying out diagnostic and therapeutic intrabronchial manipulations (for sanitation of the bronchial tree);
• postoperative period (to prevent the accumulation of thick viscous sputum in the bronchi).

Contraindications

Absolute contraindications:

• peptic stomach ulcer (syrup);
• exacerbation of stomach ulcer (tablets);
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption (tablets);
• age up to 6 years (tablets);
• I trimester of pregnancy, lactation period;
• increased sensitivity to the components of the drug.

Relative contraindications:

• diseases of the bronchi with excessive accumulation of secretions;
• renal or hepatic impairment;
• a history of gastric bleeding.

Instructions for use Bromhexin-Akrikhin: method and dosage

Bromhexine-Akrikhin syrup and tablets are taken orally, regardless of food intake. The recommended duration of therapy is 4–28 days.

Syrup

Recommended dosage:

• children under 2 years old: 2.5 ml 3 times a day;
• children 2-6 years old: 2.5-5 ml 3 times a day;
• children 6-14 years old: 5-10 ml 3 times a day;
• adolescents over 14 years old and adults: 10–20 ml 3-4 times a day.

Pills

Recommended dosage:

• children 6-14 years old: 8 mg 3 times a day;
• adolescents over 14 years old and adults: 8-16 mg 3-4 times a day.

Side effects

The following undesirable effects are possible: dyspepsia, nausea, vomiting, allergic reactions, exacerbation of stomach and duodenal ulcers, headache, dizziness, increased activity of hepatic transaminases.

These side effects are the reason for discontinuation of the drug.

Overdose

Symptoms of an overdose of Bromhexine-Akrikhin: diarrhea, nausea, vomiting.

Recommended treatment: artificial vomiting and gastric lavage within 60-120 minutes after taking the drug.

special instructions

Taking an additional amount of liquid improves the expectorant properties of the drug.

When treating children, it is recommended, in addition to taking the drug, to use postural drainage or vibration massage of the chest to facilitate the removal of sputum from the bronchi.

Influence on the ability to drive vehicles and complex mechanisms

During the period of application of the drug Bromhexin-Akrikhin, care should be taken when driving vehicles and other complex mechanisms that require the speed of psychomotor reactions.

Application during pregnancy and lactation

According to the instructions, Bromhexine-Akrikhin is contraindicated in the first trimester of pregnancy and during lactation.

Pediatric use

In children under 6 years of age, Bromhexin-Akrikhin syrup should be used.

With impaired renal function

Patients with impaired renal function should use the drug with caution due to the risk of impaired elimination.

For violations of liver function

Patients with hepatic impairment are advised to be careful when taking Bromhexine-Akrikhin.

Drug interactions

Co-administration with drugs that suppress the cough center is contraindicated, due to the risk of sputum accumulation in the respiratory tract. Also, bromhexine is incompatible with alkaline solutions.

When taken together with antibiotics and sulfonamides, bromhexine promotes their penetration into the bronchial secretions in the first 4–5 days of their intake.

Analogs

Bromhexine-Akrikhin analogs are Bromhexine, Solvin.

Terms and conditions of storage

Store in a dry place, away from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

The shelf life of the syrup is 4 years, of the tablets - 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Bromhexine-Akrikhin

Reviews of Bromhexine-Akrikhin prove the effectiveness of the drug in the treatment of both children and adults. In addition, among the advantages of a drug, its affordable price is often mentioned.

Price for Bromhexine-Akrikhin in pharmacies

The approximate price for Bromhexine-Akrikhin is:

• syrup, 100 ml - 150 rubles;
• tablets 4 mg, 50 pcs. - 70 rubles, tablets 8 mg, 20 pcs. - 21 rubles.

Bromhexine-Akrikhin: prices in online pharmacies

Drug name Price Pharmacy

Bromhexine-Akrikhin 8 mg tablets 20 pcs. RUB 39 Buy

Bromhexin-Akrikhin 4 mg tablets 50 pcs. RUB 65 Buy

Bromhexine-Akrikhin 4 mg / 5 ml syrup 100 ml 1 pc. 154 RUB Buy

Bromhexine-Akrikhin syrup 4mg / 5ml 100ml 201 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!