Gepon
Gepon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Hepon
ATX code: L03AX
Active ingredient: threonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamate (treonyl-glutamyl-lysyl-lysyl-glutamyl-arginyl-arginyl-glutamyl-treonyl -glutamyl-arginyl-glutamyl-lysyl-glutamate)
Manufacturer: Immafarma (Russia)
Description and photo update: 2019-26-08
Gepon is an immunostimulating agent with antiviral action.
Release form and composition
Dosage forms:
- Lyophilized powder for preparation of a solution for oral administration and external use (in vials or ampoules of 1 or 2 mg, in a blister strip 1 bottle or 1 ampoule, in a cardboard box: 1 package; or 1 package complete with 1 bottle or ampoule of solvent (5 ml of water for injection); or 1 package complete with a solvent (5 ml of water for injection) in a vial or ampoule and a disposable syringe);
- Solution for oral administration and external use (0.1%: 1 or 2 ml in vials, in a cardboard box 1 bottle complete with a syringe or pipette; 0.02%: 5 ml or 10 ml in vials, in a cardboard box 1 bottle complete with a spray nozzle, or a dropper cap, or a syringe, or a pipette).
The active substance of Gepon is a synthetic peptide consisting of 14 amino acid residues:
- 1 bottle or 1 ampoule with lyophilized powder - 1 mg, 2 mg;
- 1 ml of solution in vials of 5 and 10 ml - 0.2 mg;
- 1 ml of solution in vials of 1 and 2 ml - 1 mg.
Pharmacological properties
Pharmacodynamics
Gepon is an immunomodulatory drug with antiviral effects.
The use of the drug leads to the following effects:
- mobilization and activation of macrophages;
- induction of α- and β-interferons;
- stimulating the production of antibodies to various antigens of an infectious nature;
- limiting the production of inflammatory cytokines (interleukins 1, 6, 8 and tumor necrosis factor);
- an increase in the body's resistance to infections caused by bacteria, viruses or fungi;
- suppression of virus replication.
In patients infected with HIV (human immunodeficiency virus), Gepon helps to reduce the concentration of HIV in plasma and blood cells. At the same time, there is an activation of immune responses specific to HIV. In most cases, such patients have an increase in the content of CD4 + T- and NK-cells, an increase in the functional activity of neutrophils and CD8 + T-cells, which are key links in the body's defense against viruses, bacteria and fungi. There is also an increase in the production of antibodies specific to HIV antigens and to antigens of opportunistic pathogens.
The course use of Gepon allows you to prevent recurrence of opportunistic infections for 3–6 months.
Local application of the drug in a short course is effective in the treatment of recurrent infections of the skin and mucous membranes caused by Candida fungi.
In addition, Gepon has an anti-inflammatory effect. 1-2 days after using the drug, the severity of signs of inflammation (in the form of redness and swelling, as well as a burning sensation, soreness, itching in the area of inflamed skin and mucous membranes) is significantly reduced. The use of Gepon allows you to eliminate dryness of the mucous membranes.
Indications for use
- Treatment of HIV infection;
- Restoration of weakened immunity in immunodeficient pathologies;
- Boosting immunity to protect against infections;
- Opportunistic infections caused by viruses, bacteria or fungi (treatment and prevention);
- Candidiasis of the skin and mucous membranes, including during antibiotic therapy (treatment and prevention);
- Dry mucous membranes, inflammation of the skin and mucous membranes, accompanied by redness, itching, swelling, burning and pain.
Contraindications
- Age under 12;
- Breastfeeding period;
- Individual intolerance to the drug.
During pregnancy, the use of the drug is allowed only in exceptional cases if the intended clinical effect for the mother exceeds the potential threat to the fetus.
Instructions for use of Gepon: method and dosage
Gepon in the form of a solution is used topically or taken orally.
To prepare a solution from a lyophilized powder, 5 ml of saline or water for injection should be added to the contents of a vial or ampoule.
Recommended dosage:
- Inside: 10 mg once a day;
- Local treatment of the skin and mucous membranes: 1-2 mg once a day in the form of a 0.02-0.04% solution.
Method of application, duration of treatment and frequency of procedures depend on clinical indications:
- Treatment of immunodeficiency states, opportunistic infections in HIV infection: by mouth for 1-3 months;
- Prevention and treatment of fungal infections of the genus Candida on the skin and mucous membranes: 0.02-0.04% solution in the form of local irrigation of the affected areas - 3 irrigations with an interval between procedures 1-3 days;
- Candidal vulvovaginitis, cervicitis, urethritis: in the form of irrigation of the mucous membrane of the vulva, vagina, cervix, lotions on the affected skin areas adjacent to the entrance to the vagina;
- Candidal urethritis, balanoposthitis: in the form of instillation into the urethra and lotions on the skin of the affected area of the body;
- Prevention of candidiasis of the skin and mucous membranes against the background of intensive antibiotic therapy: concomitant use of irrigation or lotions during the entire period of treatment;
- Inflammation of the skin and mucous surfaces of the body: in the form of applications from gauze soaked in solution and irrigation.
Side effects
When using Gepon in accordance with the recommended dosage regimen, undesirable effects have not been established.
Overdose
There is no information about an overdose.
special instructions
According to the results of clinical studies, local activation of the immune system has a positive effect on the treatment of erosive and ulcerative lesions of the gastro-duodenal zone in elderly patients.
The use of Gepon is indicated both as monotherapy and in combination with trichopolum, amoxicillin, omeprazole.
In the treatment of dysbiosis and irritable bowel syndrome, local activation of the immunity of the intestinal mucosa is effective using microclysters with the drug, including in the form of monotherapy.
Application during pregnancy and lactation
- pregnancy: Gepon can be used only in cases where the expected benefit is higher than the possible risk;
- lactation period: therapy is contraindicated.
Pediatric use
According to the instructions, Gepon is contraindicated in patients under 12 years of age.
Drug interactions
When Gepon is combined with other drugs, no clinically significant interaction has been established.
Analogs
Analogs of Gepon are: Isoprinosine, Immunomax, Diucifon, Galavit, Glutoxim, Alloferon, Polyoxidonium.
Terms and conditions of storage
Store in a dark, dry place at temperatures up to 8 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gepona
According to reviews, Gepon is an effective drug. It is widely used in women in the treatment of candidal vaginitis and vulvovaginitis. The drug is often included in the complex therapy of constantly recurrent, severe diseases of various etiologies.
Price for Gepon in pharmacies
The approximate price of Gepon (lyophilized powder for preparation of a solution for oral administration and external use, 1 bottle or ampoule of 2 mg) is 710–881 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
