Vero-Loperamide
Vero-Loperamide: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Vero-Loperamide
ATX code: A07DA03
Active ingredient: loperamide (Loperamide)
Manufacturer: JSC "Veropharm" (Russia)
Description and photo update: 2019-11-07
Vero-Loperamide is an antidiarrheal agent.
Release form and composition
Dosage form - tablets: flat-cylindrical, white or white-yellowish in color (10 pcs. In blister strip packs, 10 or 20 pcs. In light-protective glass cans, in a cardboard box 1-2 packs or 1 can and instructions for use Vero-Loperamide).
Composition of 1 tablet:
- active substance: loperamide hydrochloride - 2 mg;
- auxiliary components: potato starch, milk sugar (lactose), talc, magnesium stearate, aerosil (colloidal silicon dioxide), polyvinylpyrrolidone (povidone).
Pharmacological properties
Pharmacodynamics
Loperamide binds to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), inhibits the release of acetylcholine and prostaglandins, thereby reducing the tone and motility of intestinal smooth muscles. Slowing down peristalsis, increases the transit time of intestinal contents. Increases the tone of the anal sphincter, reduces the urge to defecate, retains stool.
After taking the drug orally, the effect develops quickly and lasts up to 4-6 hours.
Pharmacokinetics
When administered orally, loperamide is absorbed by about 40%. The maximum plasma concentration reaches within 2.5 hours. It binds to plasma proteins by 97%. It does not penetrate the blood-brain barrier.
It is metabolized almost completely in the liver by conjugation. The half-life is from 9 to 14 hours. It is excreted from the body mainly in the feces through bile, in a small amount is excreted in the urine.
Indications for use
Vero-Loperamide is used for the symptomatic treatment of acute and chronic diarrhea of various origins: allergic, drug, emotional and radiation genesis; due to changes in the qualitative composition of food and / or diet; against the background of impaired absorption and metabolism.
As an adjuvant, Vero-Loperamide is used for infectious diarrhea.
For patients with ileostomy, the drug is prescribed to regulate the stool.
Contraindications
Absolute:
- diarrhea against the background of acute pseudomembranous enterocolitis;
- ulcerative colitis in the acute stage;
- intestinal obstruction;
- diverticulosis;
- dysentery and other infections of the gastrointestinal tract (when using the drug as monotherapy);
- children under 5 years old;
- I trimester of pregnancy;
- lactation period;
- hypersensitivity to loperamide or any auxiliary component.
Vero-Loperamide should be used with caution in patients with hepatic impairment, as well as in the II and III trimesters of pregnancy.
Vero-Loperamide, instructions for use: method and dosage
Vero-Loperamide tablets are taken orally.
The initial dose for adults is 4 mg (2 tablets), then 2 mg (1 tablet) after each bowel movement, while the stool remains loose. The maximum permissible daily dose of the drug is 16 mg (8 tablets).
In children over 5 years of age with acute diarrhea, the first and subsequent doses are 2 mg (1 tablet). The maximum daily dose is 6 mg (3 tablets).
Treatment with the drug is stopped when the stool is normalized or absent for more than 12 hours.
Side effects
- from the gastrointestinal tract (GIT): dry mouth, nausea, constipation, intestinal colic, vomiting, gastralgia; very rarely - intestinal obstruction;
- from the central nervous system (CNS): dizziness, drowsiness;
- allergic reactions: skin rash.
Overdose
In case of an overdose of Vero-Loperamide, intestinal obstruction may develop, as well as depression of the central nervous system (drowsiness, impaired coordination of movements, muscle hypertension, miosis, stupor, respiratory depression).
The antidote to loperamide is naloxone (it may need to be re-administered because loperamide has a longer duration of action). Treatment of an overdose is symptomatic: gastric lavage, intake of activated carbon. If necessary, artificial lung ventilation is performed. The patient must be under medical supervision for at least 48 hours.
special instructions
If after 2 days of regular intake of the drug there is no effect, you need to consult a doctor to clarify the diagnosis and exclude diarrhea of infectious origin.
Discontinue Vero-Loperamide if bloating or constipation occurs.
During the treatment of diarrhea, fluid and electrolyte loss is required.
Loperamide is not recommended to be taken in cases where it is necessary to inhibit intestinal motility.
Influence on the ability to drive vehicles and complex mechanisms
Due to the risk of negative reactions from the central nervous system, it is recommended to refrain from driving a car and performing potentially hazardous work during drug treatment.
Application during pregnancy and lactation
Vero-Loperamide is contraindicated in the first trimester of pregnancy. In the II and III trimesters, it should be used with extreme caution, after assessing the benefits and possible risks.
In small quantities, loperamide penetrates into the mother's milk, therefore it is not recommended for use during lactation.
Pediatric use
Vero-Loperamide is contraindicated in children under 5 years of age.
For violations of liver function
Vero-Loperamide tablets are used with caution in liver failure. In case of impaired liver function, signs of possible toxic damage to the central nervous system should be carefully monitored.
Use in the elderly
There is no information to indicate the need to adjust the dose of Vero-Loperamide for the elderly.
Drug interactions
The bioavailability of loperamide is increased by ritonavir and co-trimoxazole (due to inhibition of its metabolism during the first passage through the liver).
Naloxone is an antidote to loperamide.
It is assumed that colestyramine, when taken together, can reduce the effect of loperamide.
Analogs
Analogs of Vero-Loperamide are: Hydrasek, Diara, Diasec, Imodium, Lopedium, Neosmectin, Superilop, Usara, Endosorb, Enterol, etc.
Terms and conditions of storage
Store in a dry, dark place, out of reach of children, at a temperature not exceeding + 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Vero-Loperamide
According to reviews, Vero-Loperamide is a very effective antidiarrheal agent. As indicated by most patients, the effect of the drug develops quickly and lasts for a long time, there are no negative reactions. And what is important, the drug is cheap. Many believe that such a remedy must be present in a home medicine cabinet.
Price for Vero-Loperamide in pharmacies
The price of Vero-Loperamide for a pack of 20 2 mg tablets is 19-24 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
