Bronchobos
Bronchobos: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Bronchobos
ATX code: R05CB03
Active ingredient: carbocisteine (carbocisteine)
Manufacturer: Bosnalijek (Bosnia and Herzegovina)
Description and photo update: 2019-16-08
Prices in pharmacies: from 240 rubles.
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Bronchobos is an expectorant drug that dilutes phlegm and facilitates its further removal from the lungs.
Release form and composition
The drug is available in two forms:
- Capsules: yellow, opaque, hard, gelatinous, filled with fine white powder. 1 capsule contains 375 mg of carbocysteine, the main active ingredient. Auxiliary components: magnesium stearate, gelatin, corn starch, colloidal silicon dioxide. Packaged in PVC / aluminum blisters of 10 capsules, 3 blisters in a carton box;
- Syrup: slightly viscous, transparent liquid with a raspberry smell, color from pink to deep red. The content in the syrup of the main active ingredient, carbocysteine, is 125 mg (2.5%) or 250 mg (5%). Auxiliary components: citric acid, ethyl alcohol 96%, sodium saccharin, sodium hydroxide, glycerol, methyl parahydroxybenzoate, sodium carboxymethyl cellulose, propyl parahydroxybenzoate, raspberry flavor, azorubin CL 14720 (E122), purified water. Packing - brown glass bottles of 200 ml of syrup, a lid with a first opening control, with a measuring spoon, in a cardboard box.
Pharmacological properties
Pharmacodynamics
The mucolytic and expectorant effects of carbocisteine are associated with the activation of sialic transferase, an enzyme of goblet cells localized on the bronchial mucosa. The substance normalizes the quantitative ratio of neutral and acidic sialomucins contained in bronchial secretions. The drug reduces the viscosity of the discharge from the paranasal sinuses and bronchial secretions, improves the discharge of mucus and sputum, and reduces the severity of the cough reflex.
Carbocisteine provides regeneration of the mucous membrane, restoring its structure, and intensifies the activity of the ciliated epithelium. It also improves the production of IgA immunoglobulin, which is responsible for specific protection, and normalizes mucociliary clearance and the number of sulfhydryl groups of mucus components responsible for nonspecific protection.
Pharmacokinetics
When taken orally, the absorption rate of carbocysteine is quite high, but it has a low bioavailability (less than 10% of the dose taken). Its maximum level in the mucous membrane of the respiratory tract and in the blood serum is recorded 2-3 hours (for capsules) or 1.5-2 hours (for syrup) after taking Bronchobos inside and remains in the mucous membrane for 8 hours. Cumulation of the drug is observed in the blood, middle ear and liver. Also in high concentrations, it is determined in bronchial secretions (17.5% of the dose taken).
The substance is metabolized in the liver and has a first pass effect through the liver. Carbocisteine is excreted in the urine (60-90% is excreted unchanged, the rest is excreted as metabolites). The half-life is approximately 2 hours, and complete excretion is achieved 3 days after taking the drug.
Indications for use
According to the instructions, Bronchobos is indicated in the case of:
- Chronic and acute bronchopulmonary diseases, which are accompanied by a violation of the formation and excretion of sputum (bronchitis, tracheitis, tracheobronchitis, bronchial asthma, etc.);
- Inflammatory diseases of the paranasal sinuses and middle ear (sinusitis, otitis media, rhinitis);
- Preparing the patient for bronchography or bronchoscopy.
Contraindications
Bronchobos in any form of release cannot be taken with:
- Hypersensitivity to carbocisteine and / or drug excipients;
- Cystitis;
- Peptic ulcer of the duodenum and stomach in the acute stage;
- Chronic glomerulonephritis in the acute phase.
Syrup of any concentration is contraindicated in:
- Liver disease;
- Alcoholism;
- Epilepsy;
- Brain trauma or pathology.
You should not use Bronchobos syrup throughout pregnancy and during breastfeeding. The drug in the form of capsules is contraindicated in the first trimester of pregnancy.
Take with caution with a history of gastric ulcer and duodenal ulcer.
With a history of chronic glomerulonephritis, pregnancy in the II-III trimester and breastfeeding, taking Bronchobos capsules is possible only under close medical supervision.
Bronchobos in the form of capsules and syrup 5% is contraindicated in children under 15 years of age. In the form of a syrup, 2.5% is contraindicated in children under 3 years of age.
Instructions for use of Bronchobos: method and dosage
Bronchobos in any form of release is intended for oral administration.
Syrup
Recommended doses of Bronchobos syrup for children:
- From 3 to 6 years old - 5 ml of 2.5% syrup (1 scoop) 2-4 times a day;
- Over 6 years old - 5-10 ml of 2.5% syrup (1-2 scoops) 3 times a day.
Adults are prescribed 15 ml of 5% syrup (3 scoops) 3 times a day.
Capsules
Adults and adolescents over 15 years old in a daily dose of 2.25 g of carbocisteine - 2 capsules 3 times a day.
When the therapeutic effect is achieved, the daily dose is reduced to 1.5 g - 2 capsules 2 times a day.
The course of drug treatment should not exceed 8 days. If it is necessary to prolong the treatment, consult your doctor.
Side effects
The use of Bronchobos can cause the following side effects:
- Gastrointestinal tract: nausea, vomiting, diarrhea and epigastric pain, bleeding in the gastrointestinal tract (extremely rare).
- Allergic reactions: pruritus, exanthema, urticaria, angioedema;
- Other: weakness, general loss of strength, dizziness.
There is a possibility of airway obstruction in elderly patients and patients with bronchial asthma.
Overdose
An overdose of Bronchobos is determined by such signs as diarrhea, nausea, gastralgia. Symptomatic treatment is recommended.
special instructions
When taking the drug in the form of a syrup, it is important to take into account that the alcohol content in it is 125 mg in one measuring spoon (in 5 ml of liquid). This may affect the patient's ability to perform work requiring special concentration of attention or drive vehicles and complex mechanisms due to a decrease in the speed of psychomotor responses due to the presence of alcohol in the blood.
Bronchobos in capsules is prescribed in low doses if the patient has a history of gastric ulcer and / or duodenal ulcer. In this case, to enhance the effect of treatment, taking the drug should be combined with physiotherapy procedures.
Influence on the ability to drive vehicles and complex mechanisms
At the moment, it is not known how the reception of Bronchobos affects the ability to drive vehicles and perform potentially dangerous work, requiring increased concentration and immediate psychomotor reactions, due to the lack of relevant studies.
Drug interactions
Carbocisteine makes antibacterial and glucocorticosteroid therapy more effective, used in diseases of the upper and lower respiratory tract of an inflammatory nature, and enhances the bronchodilator effect of theophylline. The combination of Bronchobos with antitussive and atropine-like agents helps to weaken the activity of carbocisteine.
Analogs
Direct analogues of Bronchobos in terms of active ingredient (carbocisteine): Fluifort, Libeksin Muko, Fluditek, Mukosol, Mukodin.
Terms and conditions of storage
Store at a temperature of 15-30 ° C, out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Bronchobos
According to reviews, Bronchobos is considered a high-quality and effective drug from the mucolytic group. Patients note that it dilutes well and removes mucus from the bronchi. Good results are obtained by using it in children from 3 years of age, which is ensured by a minimum of contraindications and adverse reactions.
Price for Bronchobos in pharmacies
On average, the price of Bronchobos in capsules is 277‒395 rubles (the package contains 30 pcs.). You can buy 2.5% syrup for about 230-436 rubles, and 5% syrup for 331-499 rubles (for a 200 ml bottle).
Bronchobos: prices in online pharmacies
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Drug name Price Pharmacy |
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Bronchobos 125 mg / 5 ml syrup 200 ml 1 pc. 240 RUB Buy |
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Bronchobos 375 mg capsules 30 pcs. RUB 291 Buy |
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Bronchobos 250 mg / 5 ml syrup 200 ml 1 pc. 321 r Buy |
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Bronchobos capsules 375mg 30 pcs. 342 r Buy |
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Bronchobos syrup 125mg / 5ml 200ml 381 r Buy |
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Bronchobos syrup 250mg / 5ml 200ml 402 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
