Beklazon Eco
Beklazon Eco: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Beclazone Eco
ATX code: R03BA01
Active ingredient: beclometasone (beclometasone)
Producer: Norton Waterford trading as IVAX Pharmaceuticals Ireland (Ireland)
Description and photo updated: 22.11.2018
Prices in pharmacies: from 199 rubles.
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Beklazon Eco is an inhalation drug intended for the basic therapy of bronchial asthma.
Release form and composition
The dosage form of Beklazon Eco is an aerosol for inhalation metered: placed under pressure in an aluminum can; external damage, leaks or corrosion must be absent; when sprayed on glass, the contents of the can leaves a white spot (in a cardboard box 1 bottle of 200 doses).
Composition of 1 dose:
- active substance: beclomethasone dipropionate - 0.05 mg, 0.1 mg or 0.25 mg;
- auxiliary components (0.05 / 0.1 / 0.25 mg): ethanol - 2.09 / 3.11 / 6 mg; hydrofluoroalkane (HFA-134a) - 75.86 / 74.79 / 71.75 mg.
Pharmacological properties
Pharmacodynamics
Beclomethasone belongs to the number of corticosteroids (glucocorticosteroids). Has a weak tropism for GCS receptors.
Under the influence of enzymes, it is converted into an active metabolite - B-17-MP (beclomethasone-17-monopropionate), which has a pronounced local anti-inflammatory effect.
Basic properties of Beklazon Eco:
- reduction of inflammation by reducing the formation of chemotaxis substance (influence on late allergy reactions);
- inhibition of the development of an immediate allergic reaction (associated with inhibition of the production of metabolites of arachidonic acid and a decrease in the release of inflammatory mediators from mast cells);
- improving mucociliary transport;
- a decrease in the number of mast cells in the bronchial mucosa;
- reduction of epithelial edema, mucus secretion by bronchial glands, bronchial hyperreactivity, marginal accumulation of neutrophils, inflammatory exudate and production of lymphokines;
- inhibition of macrophage migration;
- decrease in the intensity of granulation and infiltration processes;
- an increase in the number of active beta-adrenergic receptors;
- restoration of the patient's response to bronchodilators, which reduces the frequency of their use.
Beclomethasone after inhalation has practically no resorptive effect.
Beklazon Eco does not relieve bronchospasm. The development of the therapeutic effect occurs gradually, as a rule, after 5-7 days of course use.
Pharmacokinetics
More than 1/4 of the dose of inhaled beclomethasone is deposited in the respiratory tract, the rest is deposited in the mouth, pharynx and is swallowed. In the lungs, beclomethasone is extensively metabolized to the active metabolite B-17-MP before absorption.
Systemic absorption of the B-17-MP metabolite occurs in the lungs (36% of the pulmonary fraction), in the gastrointestinal tract (26% of the dose received by ingestion).
The absolute bioavailability of unchanged beclomethasone and B-17-MP is approximately 2 and 62% of the inhalation dose, respectively. Beclomethasone is rapidly absorbed, T max (time to reach the maximum concentration in blood plasma) - 18 minutes. The absorption of B-17-MP is slow, its T max is 60 minutes.
There is a linear relationship between the increase in the dose received and the systemic exposure of the substance.
Distribution in tissues of beclomethasone and B-17-MP - 20 and 424 liters, respectively. There is a relatively high connection with blood plasma proteins - 87%.
Beclomethasone and B-17-MP have high plasma clearance (150 and 120 l / h, respectively). The half-life is 0.5 and 2.7 hours, respectively.
Indications for use
According to the instructions, Beklazon Eco is prescribed for the basic therapy of various forms of bronchial asthma.
Contraindications
Absolute:
- age up to 4 years;
- individual intolerance to the components of the drug.
Relative (Beklazon Eco is prescribed under medical supervision):
- cirrhosis of the liver;
- glaucoma;
- systemic infections (bacterial, viral, fungal, parasitic);
- hypothyroidism;
- pulmonary tuberculosis;
- osteoporosis;
- pregnancy and the period of breastfeeding.
Instructions for use of Beklazon Eco: method and dosage
Aerosol Beklazon Eco is intended for inhalation administration. For its application, an inhalation device is used. After the end of each inhalation, the mouth and throat must be thoroughly rinsed with water.
The drug should be used regularly, even in the absence of symptoms of the disease. The dose is selected by the physician individually based on clinical efficacy. After switching to a high dose of inhaled beclomethasone, most patients receiving systemic corticosteroids reduce their dose or cancel it completely.
The initial dose of Beklazon Eco depends on the severity of bronchial asthma:
- mild course: FEV (forced expiratory volume) or PSV (peak expiratory flow rate) is more than 80% of the required values with a range of PSV indicators up to 20%;
- moderate course: FEV or PSV is from 60 to 80% of the proper values, the daily range of PSV indicators is in the range of 20-30%;
- severe course: FEV or PSV - less than 60% of the required values, the daily range of PSV indicators is more than 30%.
The daily dose is divided into several doses (from 2 to 4 inhalations per day).
Adults and children from 12 years old
Recommended starting daily dose of Beklazon Eco:
- mild course: 0.2-0.6 mg (for 2 inhalations);
- moderate course: 0.6-1 mg (for 2-4 inhalations);
- severe course: 1-2 mg (for 2-4 inhalations).
The standard maximum daily dose is 1 mg. In a very severe course, it can be increased to 1.5–2 mg (for 2–4 inhalations).
Treatment of bronchial asthma is based on a stepwise approach. Therapy should be started according to the stage that corresponds to the severity of the disease. Inhaled corticosteroids are prescribed from the second stage.
Recommended dosage regimen:
- Stage II: basic therapy; 0.1-0.4 mg 2 times a day;
- Stage III: basic therapy; Beklazon Eco can be used in a high daily dose or in combination with long-acting inhaled beta 2 -adrenomimetics in a standard daily dose; the recommended daily dose is 0.8-1.6 mg, in some cases it can reach 2 mg;
- Stage IV – V: severe bronchial asthma; the recommended daily dose is 0.8-1.6 mg, in some cases it can reach 2 mg.
Children aged 4-12
The recommended initial daily dose is 0.1–0.2 mg (for 2 inhalations). The standard maximum daily dose is 0.2 mg. In very severe cases, it can be increased to 0.4 mg (for 2-4 inhalations).
Aerosol Beklazon Eco with a single dose of 0.25 mg beclomethasone is not intended for use in this group of patients.
Additional Information
If inhalation is accidentally missed, the next dose should be taken in accordance with the treatment regimen at the appropriate time. The introduction can be carried out using special dispensers (spacers), which improve the distribution of the drug in the lungs and reduce the likelihood of adverse reactions.
Before using the inhalation device for the first time, or in cases where it has not been used for some time, you should check its serviceability. To do this, you must press the valve on the can and release the dose of medicine into the air.
Before using Beklazon Eco, you need to remove the protective cap from the inhalation device and make sure that the outlet tube is clean.
The inhalation device must be held vertically between the index and thumb, with the thumb on the bottom of the inhalation device and the index finger on the top of the aluminum can.
The aluminum can must be shaken vigorously vertically.
You should take a deep exhalation through the mouth, then tightly clamp the outlet tube of the inhalation device with your lips and take a deep and slow breath. At the moment of inhalation with the index finger, you need to press the metering valve of the cylinder, while the dose of Beklazon Eco is released. Continue to inhale slowly.
It is necessary to get the inhalation device out of your mouth and hold your breath for 10 seconds or for a time that does not cause discomfort, then exhale slowly.
After the end of the procedure, you need to rinse your mouth with water, trying not to swallow the drug that has got on the mucous membrane of the oral cavity during inhalation.
If you need to introduce a second dose, you should wait 1 minute and repeat all steps.
The inhalation device should be cleaned at least once a week. To do this, remove the aluminum cylinder from it. Then it is necessary to rinse the inhalation device and the protective cap with warm water. Do not use hot water. To remove the remaining water, shake the inhalation device and the cap. Dry them without using heating devices. The aluminum cylinder must not be allowed to come into contact with water.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01%, including isolated messages - very rare):
- endocrine system (with prolonged use of doses of more than 1500 mg per day): very rarely - suppression of the HPA (hypothalamic-pituitary-adrenal system);
- respiratory system: often - hoarseness, irritation of the pharyngeal mucosa; rarely - paradoxical bronchospasm; very rarely - eosinophilic pneumonia;
- musculoskeletal system: very rarely - a decrease in bone mineral density;
- organ of vision: very rarely - glaucoma, cataract;
- allergic reactions: rarely - angioedema, erythema, pruritus, skin rash, urticaria;
- infectious diseases (with prolonged use in doses of 0.4 mg per day): often - candidiasis of the oral cavity, pharynx and upper respiratory tract;
- systemic reactions: nausea, headache, thinning of the skin or bruising.
Overdose
An acute overdose of Beklazon Eco can develop with inhalation of a single dose of more than 1000 mg. Symptoms of suppression of the function of the adrenal cortex do not require emergency therapy, since the violation disappears within a few days.
In the case of chronic overdose (long-term therapy at a dose of more than 1500 mg), persistent suppression of the adrenal cortex function may develop. At the same time, monitoring of the reserve function of the adrenal cortex is shown.
Treatment with beclomethasone in case of overdose can be continued in doses that are sufficient to maintain the therapeutic effect.
special instructions
If the effectiveness of the usual dose decreases, or the duration of action of Beklazon Eco decreases, you should consult your doctor. You cannot change the dosage regimen yourself.
When therapy is carried out using high doses (from 0.4 mg per day), candidiasis of the oral cavity and pharynx can develop, especially in patients who have previously had a fungal infection. The use of antifungal drugs usually helps to eliminate fungal infections quickly. In this case, you should not change the dose of beclomethasone.
If Beklazon Eco is prescribed while taking corticosteroids inside, then you can start reducing the dose of the latter after 7-14 days. In most cases, patients who take no more than 15 mg of prednisolone can completely switch to the use of inhaled beclomethasone alone. During the first months after the transition to inhalation therapy with beclomethasone, careful monitoring of the state of the HPA is required.
Against the background of reduced adrenal function after a complete transition to Beklazon Eco, patients should always have a supply of GCS with them, and also carry a card with information that in stressful situations they need systemic GCS.
With a sudden and progressive deterioration in the course of bronchial asthma, an increase in the dose of GCS is required. An indirect indicator of treatment failure is the more frequent use of short-acting beta 2 -adrenomimetics.
For relief of attacks of bronchospasm, beta 2 -adronomimetics, including salbutamol, should be used. In a severe course of the disease or insufficient effectiveness of Beklazon Eco, it is necessary to increase its dose, and also consider the use of GCS inside. It is also possible to use antibacterial drugs, in particular for infectious inflammation.
In case of paradoxical bronchospasm, Beklazon Eco is canceled. After the examination, the doctor decides on the appointment of another drug.
It is impossible to abruptly interrupt therapy.
With long-term use of Beklazon Eco in children, the dynamics of their growth should be controlled.
Caution should be exercised when using the drug in patients with active / inactive pulmonary tuberculosis.
Avoid getting Beklazon Eco in the eyes.
Application during pregnancy and lactation
Beklazon Eco should be used under medical supervision during pregnancy / lactation.
Pediatric use
Beklazon Eco is not prescribed for patients under 4 years of age.
Drug interactions
Beklazon Eco restores the reaction to beta-adrenomimetics, which reduces the frequency of their use.
Possible interactions:
- beta-adrenomimetics: their effect is enhanced;
- methandienone, estrogens, beta 2 -adrenomimetics, theophylline, systemic corticosteroids: the effectiveness of beclomethasone increases;
- phenobarbital, phenytoin, rifampicin and other inducers of microsomal liver enzymes: the effectiveness of beclomethasone decreases.
Analogs
Analogs of Beklazon Eco are: Beklazon Eco Light Breathing, Rinoclenil, Beclomethasone, Bozon, Nasobek, Klenil, Beclospir.
Terms and conditions of storage
Store in a place protected from direct sunlight at temperatures up to 25 ° C. Keep out of the reach of children. Do not freeze.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Beklazone Eco
According to reviews, Beklazon Eco is effective with constant use. It is noted that the drug has an acceptable cost. Of the shortcomings, they indicate the development of side effects, including stomatitis.
Price for Beklazon Eco in pharmacies
The approximate price for Beklazon Eco for 1 bottle is: 0.05 mg / dose - 180-196 rubles, 0.1 mg / dose - 249-343 rubles, 0.25 mg / dose - 361-491 rubles.
Beklazon Eco: prices in online pharmacies
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Drug name Price Pharmacy |
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Beklazon Eco 50 mcg / dose 200 doses aerosol for inhalation metered 1 pc. 199 RUB Buy |
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Beklazon eco aeros. d / inhalation doses. 50 μg / dose 200 doses n1 205 RUB Buy |
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Beklazon Eco Light Breathing 50 mcg / dose 200 doses inhalation aerosol activated by inhalation (light breathing) 1 pc. RUB 218 Buy |
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Beklazon Eco 100 mcg / dose 200 doses aerosol for inhalation metered dose 1 pc. 282 r Buy |
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Beklazon ECO aerosol for in. dosage. 0.1mg / dose 200 doses 332 RUB Buy |
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Beklazon Eco 250 mcg / dose 200 doses aerosol for inhalation metered 1 pc. 366 r Buy |
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Beklazon Eco Light Breath 250 mcg / dose 200 doses inhalation aerosol activated by inhalation (light breathing) 1 pc. 443 r Buy |
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Beklazon ECO aerosol for in. dosage. 250mcg / dose 200 doses 464 r Buy |
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Beklazon Eco Light Breathing 100 mcg / dose 200 doses inhalation aerosol activated by inhalation (light breathing) 1 pc. 575 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
