Methylprednisolone - Instructions, Application, Indications

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Methylprednisolone

Instructions for use:

1. 1. Pharmacological action
2. 2. Release form
3. 3. Indications for use
4. 4. Contraindications
5. 5. Instructions for use
6. 6. Side effects

Methylprednisolone is a hormonal drug.

pharmachologic effect

Methylprednisolone refers to glucocorticosteroids, has anti-shock, immunosuppressive, anti-allergic, anti-inflammatory, desensitizing, anti-toxic effects.

The drug tends to increase the excitability of the nervous system, reduce the number of lymphocytes, and increase the number of erythrocytes.

Taking part in protein metabolism, Methylprednisolone reduces the amount of protein, stimulates the production of albumin in the liver and kidneys, and enhances the processing of protein in the muscles.

In the process of lipid metabolism, Methylprednisolone increases the production of higher fatty acids, redistributes fatty deposits (mainly on the abdomen, shoulder girdle, face).

Taking part in the metabolism of carbohydrates, Methylprednisolone stimulates the absorption of carbohydrates from the gastrointestinal tract, increases the amount of glucose entering the blood from the liver.

In electrolyte-water metabolism, Methylprednisolone plays the role of a substance that retains water and sodium, stimulates the excretion of potassium, reduces the absorption of calcium from the gastrointestinal tract, and increases the excretion of calcium by the kidneys.

Methylprednisolone aceponate is a glucocorticosteroid for external use, has antiallergic, anti-inflammatory, antiexudative effect.

When the application is applied to the vessels, it exhibits a vasoconstrictor effect (suppresses the secretion of mucus from the vessels of the tissues).

Release form

Methylprednisolone is produced in tablets, solution. Methylprednisolone aceponate - in the form of an ointment.

Indications for the use of Methylprednisolone

Methylprednisolone is taken for collagenosis (diseases that are characterized by diffuse damage to connective tissues and blood vessels), for rheumatism, nonspecific infectious polyarthritis, bronchial asthma, myeloid leukemia, acute lymphoblastic leukemia, infectious mononucleosis, neurodermatitis, eczema, other diseases of the skin.

Also, the instructions for Methylprednisolone indicate that it can be prescribed for Addison's disease, acute adrenal cortex insufficiency, hemolytic anemia, acute pancreatitis, glomerulonephritis, patients in a state of collapse and shock, those who have undergone tissue and organ transplantation (to prevent rejection).

Methylprednisolone aceponate is effective for neurodermatitis, atopic dermatitis, degenerative eczema, contact, dyshidrotic.

You can also use the ointment to treat eczema in children.

Contraindications

According to the instructions, methylprednisolone should not be prescribed for severe hypertension, diabetes mellitus, Itsenko-Cushing's disease, acute endocarditis, circulatory insufficiency of the 3rd stage, osteoporosis, gastrointestinal ulcers, syphilis, tuberculosis in the active phase, after recent operations. Pregnant women, elderly patients, children under 12 years old do not take Methylprednisolone.

Methylprednisolone aceponate is contraindicated for specific skin lesions: chickenpox, tuberculosis, syphilis, for skin reactions to vaccination, for viral diseases.

Instructions for the use of Methylprednisolone

Methyleprednisolone intravenously, intramuscularly injected with adrenal insufficiency in children in the following volumes: 0.14 mg / kg / day h / z for two days. For other indications, children are injected with 0.139-0.835 mg / kg every 12-24 hours. Adults are shown to inject 4-60 mg / day for 1-4 weeks.

In a state of cardiogenic, burn, anaphylactic, traumatic shock or rejection of transplanted organs, tissues, children and adults are injected intravenously 4-20 mg / kg of Methylprednisolone. Over a short period, the dosage can be increased to 30mg / kg. The duration of intravenous infusion is not less than 10 minutes at intervals of 30 minutes - a day.

To eliminate vomiting, nausea, provoked by cytostatics, 250 mg of methyleprednisolone is taken 20 minutes (or 6 hours after) before taking the drugs. Children are given at least 25 mg / day.

In bronchial asthma, Methylprednisolone is taken orally - starting treatment with a daily dose of 12-40 mg. Maintenance treatment - 4-12 mg / day.

For the treatment of chronic polyarthritis, take 6-20 mg per day (at the beginning of therapy). In the treatment of rheumatism, the starting dose of Methylprednisolone according to the instructions is 0.8-1.5 mg / kg (it is gradually reduced).

Ointment Methylprednisolone aceponate is applied once a day to the area affected by eczema with a thin layer, gently rubbed. It is allowed to use an ointment with an occlusive dressing. Therapy for adult patients lasts no more than 12 weeks and no more than 4 weeks for children. Several courses of treatment can be carried out throughout the year.

Side effects

Methylprednisolone causes a retention of sodium, water, leads to a loss of potassium, can provoke an increase in pressure, weakening of muscles, damage to the walls of the stomach, menstrual irregularities, and adrenal function.

Because of Methylprednisolone, osteoporosis, mental disorders can develop, and resistance to infections can decrease.

Ointment with prolonged therapy can cause erythema, rash, burning, itching, skin atrophy, acne, hypertrichosis, folliculitis, dermatitis, allergic reactions.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!