Rinza
Rinza: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Rinza
ATX code: N02BE71
Active ingredient: caffeine + chlorphenamine + phenylephrine + paracetamol (caffeine + chlorphenamine + phenylephrine + paracetamol)
Manufacturer: Unique Pharmaceutical Laboratories (India)
Description and photo update: 2019-16-08
Prices in pharmacies: from 73 rubles.
Buy
Rinza is a multicomponent drug used in the symptomatic treatment of acute respiratory diseases.
Release form and composition
The dosage form of Rinza's release is tablets: flat, round, pink with white and dark pink blotches, on one side they have beveled edges and a dividing line (10 pcs. In blisters, in a cardboard box 1 or 2 packs; 10 or 20 pcs. In blisters, in a cardboard box 1 blister).
Active ingredients in 1 tablet:
- Caffeine - 30 mg
- Paracetamol - 500 mg;
- Chlorphenamine maleate - 2 mg;
- Phenylephrine hydrochloride 10 mg
Additional Rinza components: corn starch (for a 20% paste), colloidal silicon dioxide, povidone (K-30), corn starch, magnesium stearate, sodium methyl parahydroxybenzoate, sodium carboxymethyl starch (type A), talc, crimson dye (Ponso 4R).
Pharmacological properties
Rinza has antipyretic, analgesic, psychostimulating, antihistamine and anti-congestive (reduces swelling) action.
Pharmacodynamics
Paracetamol provides antipyretic and analgesic effects of Rinza. It helps to eliminate fever, and also relieves headaches, pain arising from acute respiratory viral infections, pain in the throat, back, joints.
Paracetamol is an inhibitor of the enzymes cyclooxygenase-1 and cyclooxygenase-2, reduces the production of prostaglandins and affects the center of thermoregulation of the nervous system. In the inflamed tissues, the substance is blocked by specific enzymes, therefore, the inactivation of COX-1 and COX-2 in them is insignificant. This explains the weak anti-inflammatory effect of paracetamol. However, it successfully inhibits the production of prostaglandins in the cells of the nervous system, therefore, it reduces elevated body temperature, while not affecting its normal parameters. The substance does not affect the gastric mucosa, unlike other NSAIDs. Taking paracetamol in therapeutic doses does not change the course of water-electrolyte metabolism and other types of metabolism.
Phenylephrine is an α 1 -adrenomimetic that helps to reduce the lumen of blood vessels, which allows you to eliminate edema and hyperemia of the mucous membrane of the nasopharynx, nose and paranasal sinuses.
Chlorphenamine belongs to the blockers of histamine H 1 -receptors and is characterized by an antiallergic effect, which is expressed in the elimination of exudative manifestations, a decrease in swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses, and a decrease in the severity of itching of the throat, nose and eyes.
Caffeine stimulates the nervous system, reducing feelings of fatigue and sleepiness and increasing physical and mental performance. The compound enhances the analgesic effect of paracetamol and accelerates its onset.
Pharmacokinetics
Rinza's pharmacokinetic profile is currently not available. However, it is known that paracetamol is rapidly absorbed from the middle sections of the gastrointestinal tract and intensively binds to plasma proteins. Its maximum concentration in blood plasma is reached approximately 1 hour after ingestion. Paracetamol also crosses the blood-brain and placental barriers.
Indications for use
According to the instructions, Rinza is used in the symptomatic treatment of colds, acute respiratory viral infections (ARVI), including influenza, occurring with pain, rhinorrhea and fever.
Contraindications
Absolute:
- Diabetes mellitus in severe course;
- Severe atherosclerosis of the coronary arteries;
- Arterial hypertension in severe course;
- Combined use with preparations containing components of Rinza;
- Combined use with tricyclic antidepressants, monoamine oxidase inhibitors, beta-blockers;
- Age up to 15 years;
- The period of pregnancy and breastfeeding;
- Hypersensitivity to drug components.
Relative (Rinz tablets should be taken with caution in the presence of conditions / diseases such as):
- Diseases of the blood;
- Hyperplasia of the prostate;
- Arterial hypertension;
- Bronchial asthma;
- Hyperthyroidism;
- Diabetes;
- Deficiency of glucose-6-phosphate dehydrogenase;
- Pheochromocytoma;
- Chronic obstructive pulmonary disease;
- Congenital hyperbilirubinemia (Dubin-Johnson, Gilbert, Rotor syndromes);
- Closed-angle glaucoma;
- Hepatic / renal impairment.
Instructions for use of Rinza: method and dosage
Rinz tablets are taken orally.
Single dose - 1 tablet. The recommended frequency of taking the drug is 3-4 times a day (maximum - 4 tablets a day).
The duration of the treatment course is up to 5 days.
Side effects
- Cardiovascular system: increased blood pressure, tachycardia;
- Urinary system: interstitial nephritis, glucosuria, renal colic, papillary necrosis;
- Digestive system: dry mouth, nausea, vomiting, pain in the epigastric region, hepatotoxic effect;
- Respiratory system: bronchial obstruction;
- Hematopoietic system: pancytopenia, anemia, agranulocytosis, thrombocytopenia, aplastic / hemolytic anemia, methemoglobinemia;
- Central nervous system: violation of falling asleep, dizziness, increased irritability;
- Organ of vision: paresis of accommodation, dilated pupil, increased intraocular pressure;
- Allergic reactions: itching, angioedema, skin rash, urticaria.
Overdose
Rinza overdose is most often caused by paracetamol and manifests itself after taking the latter in high doses (10-15 g). Among the possible symptoms, it is worth noting an increase in prothrombin time, increased activity of hepatic transaminases, pallor of the skin, hepatonecrosis, nausea, vomiting, and anorexia. If you suspect an overdose, you should immediately consult a doctor.
As a treatment, gastric lavage is usually recommended, followed by the intake of a sorbent (activated carbon). In the future, symptomatic therapy is also prescribed, including the introduction of methionine 8-9 hours after the overdose and acetylcysteine - 12 hours later.
special instructions
While taking Rinza, you need to refrain from drinking alcohol, anxiolytic / hypnotic drugs.
Do not take the drug in combination with other drugs containing paracetamol.
During the period of therapy, it is necessary to refuse to drive vehicles and work in which the patient requires an increased concentration of attention and quick psychomotor reactions.
Drug interactions
The combined use of Rinza with certain drugs / substances can lead to the development of the following effects:
- Halothane: increased likelihood of ventricular arrhythmias;
- Monoamine oxidase inhibitors, sedatives, ethanol: enhancing their action;
- Antidepressants, antiparkinsonian / antipsychotics, phenothiazine derivatives: increased likelihood of developing dry mouth, urinary retention, constipation;
- Tricyclic antidepressants: enhancing the adrenomimetic effect of phenylephrine;
- Glucocorticosteroids: increased likelihood of developing glaucoma;
- Diuretic drugs: decrease in their effectiveness;
- Monoamine oxidase inhibitors, furazolidone: development of arousal, hypertensive crisis, hyperpyrexia;
- Ethanol: enhancing the sedative effect of antihistamines;
- Barbiturates, diphenin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes: increasing the likelihood of developing hepatotoxic effects of paracetamol;
- Guanethidine: a decrease in its hypotensive action, an increase in the alpha-adrenergic activity of phenylephrine.
Analogs
Rinza's analogs are: Combigripp HotSip, Rinzasip, Fervex, Theraflu, Antigrippin, Gripout, Coldrex, Paralen Extra, Gripex Active, Antiflu.
Terms and conditions of storage
Store in a dark, dry place out of reach of children at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Rinza
Numerous reviews about Rinza, which are left by doctors and patients, are mostly positive. There are practically no reports of cases of overdose or the development of adverse reactions. Sometimes there are discussions among patients about Rinza's belonging to antibiotics, but the drug does not have an antibacterial effect, according to the explanations of experts.
Price for Rinza in pharmacies
On average, the price of Rinza in pharmacies is 139-221 rubles (the package includes 10 tablets).
Rinza: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Rinza tablets 4 pcs. 73 rbl. Buy |
|
Rinza tablets 4 pcs. RUB 81 Buy |
|
Rinza pills for colds with paracetamol, 10pcs 143 r Buy |
|
Rinza tablets 10 pcs. 143 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
