Acecardol
Acecardol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Acecardol
ATX code: B01AC06, N02BA01
Active ingredient: acetylsalicylic acid (acetylsalicylic acid)
Producer: Sintez, JSC (Russia)
Description and photo update: 2019-19-08
Prices in pharmacies: from 18 rubles.
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Acecardol is a non-steroidal anti-inflammatory drug with an antiplatelet effect.
Release form and composition
Acecardol is produced in the form of round biconvex tablets, coated in white.
1 tablet contains:
- Active substance: acetylsalicylic acid (ASA) - 50, 100 or 300 mg;
- Auxiliary components: lactose, titanium dioxide, magnesium stearate, castor oil, microcrystalline cellulose, povidone, corn starch.
Pharmacological properties
Pharmacodynamics
The active ingredient of Acecardol is acetylsalicylic acid (ASA). The mechanism of its antiplatelet effect is based on the ability to irreversibly inhibit cyclooxygenase (COX-1). As a result of this action, the synthesis of thromboxane A 2 is blocked, and platelet aggregation is suppressed. It is believed that the drug also has other mechanisms for inhibiting platelet aggregation.
The antiplatelet effect develops even when taking ASA in small doses and lasts for 7 days after a single dose.
When taken in high daily doses (more than 300 mg), ASA also has antipyretic, anti-inflammatory and analgesic effects.
Pharmacokinetics
After oral administration, ASA is rapidly and completely absorbed from the gastrointestinal tract, during which it is partially metabolized. During and after absorption, ASA is converted into the main metabolite - salicylic acid, which is metabolized mainly in the liver (under the influence of enzymes) with the formation of such metabolites as salicylic acid, salicylic acid glucuronide and phenyl salicylate. They are found in many tissues and urine. In women, the metabolic process is slower than in men.
After taking Acecardol inside, the maximum concentration of ASA in the blood plasma is observed after 10–20 minutes, salicylic acid - after 0.3–2 hours.
Acecardol tablets are coated with an acid-resistant membrane, which prevents the drug from dissolving in the stomach, so the active substance is released in the alkaline environment of the duodenum. In this regard, the absorption of ASA is carried out 3-6 hours slower than when taking conventional tablets (not covered with such a shell).
Acetylsalicylic and salicylic acids bind to blood plasma proteins (depending on the dose, this figure is 66–98%) and are quickly distributed in the body. Salicylic acid passes through the placenta and into breast milk.
The metabolism of salicylic acid is limited by the capabilities of the enzymatic system, so its excretion is dose-dependent. The half-life lasts from 2-3 hours (in the case of taking low doses) to 15 hours (when using high doses as an antipyretic and analgesic agent).
With long-term use, non-hydrolyzed ASA does not accumulate in the blood serum, unlike other salicylates.
Salicylic acid and its metabolites are excreted by the kidneys. With normal renal function, 80 to 100% of a single dose of ASA is excreted within 24-72 hours.
Indications for use
According to the instructions, Acecardol is prescribed for unstable angina pectoris, as well as for the prevention of the following diseases:
- Acute and repeated myocardial infarction in the presence of such risk factors as hyperlipidemia, diabetes mellitus, obesity, old age, smoking, arterial hypertension;
- Thromboembolism in the postoperative period and during invasive interventions on the vessels (for example, endarterectomy and angioplasty of the carotid arteries, coronary arteries and arteriovenous bypass grafting);
- Stroke (including for patients with transient circulatory disorders of the brain);
- Deep vein thrombosis and thromboembolism of the branches of the pulmonary artery (for example, with long-term immobilization due to surgery).
Contraindications
- Gastrointestinal bleeding and erosive and ulcerative lesions of the gastrointestinal tract;
- Bronchial asthma and the Fernand-Vidal triad (a combination of ASA intolerance, recurrent polyposis of the nose and paranasal sinuses and bronchial asthma);
- Hemorrhagic diathesis;
- Hypersensitivity to ASA or Acecardol's auxiliary components;
- I and III trimester of pregnancy;
- Lactation period (breastfeeding);
- Combination with methotrexate at a dosage of 15 mg per week or more;
- Age under 18.
Acecardol should be used with caution:
- Hyperuricemia;
- Gout;
- II trimester of pregnancy;
- Combination with methotrexate at a dosage of up to 15 mg per week;
- A history of renal and liver dysfunctions, gastrointestinal ulcers, nasal polyposis, chronic respiratory diseases, bronchial asthma, hay fever.
Instructions for the use of Acecardol: method and dosage
Acecardol is taken orally before meals with plenty of water. The drug is intended for long-term use.
In order to prevent pulmonary embolism and deep vein thrombosis, as well as in case of suspected acute myocardial infarction, the daily dosage of Acecardol is 100 mg, or 300 mg every other day.
In case of unstable angina pectoris, as well as for the prevention of recurrent myocardial infarction, stroke and thromboembolic postoperative complications, the minimum dosage of the drug is from 100 to 300 mg per day.
Side effects
The use of Acecardol can cause the following side effects:
- From the respiratory system: bronchospasm;
- From the side of the central nervous system: tinnitus, hearing loss, dizziness, headache;
- From the hematopoietic system: anemia, increased likelihood of bleeding;
- From the gastrointestinal tract: heartburn, vomiting, nausea, duodenal ulcer, gastric ulcer, gastrointestinal bleeding, liver dysfunction;
- Allergic reactions: itching, rash, urticaria, rhinitis, Quincke's edema, anaphylactic shock.
Overdose
Symptoms of an overdose of ASA from mild to moderate severity: hearing impairment, tinnitus, headache, dizziness, confusion, nausea, vomiting, increased sweating (including profuse), hyperventilation, tachypnea, respiratory alkalosis.
Therapeutic measures: lavage of the gastrointestinal tract, repeated intake of activated carbon, forced alkaline diuresis, restoration of the acid-base state and water-electrolyte balance.
Symptoms of an overdose of ASA from moderate to severe: tinnitus, deafness, hyperpyrexia (extremely high body temperature), disturbances in the water and electrolyte balance (dehydration, impaired renal function from oliguria to renal failure, characterized by hypernatremia, hypokalemia, hyponatremia), respiratory alopecia with compensatory metabolic acidosis, gastrointestinal bleeding, impaired glucose metabolism (ketoacidosis, hyperglycemia and hypoglycemia, especially in children), hematological disorders (from inhibition of platelet aggregation to coagulopathy, hypoprothrombinemia, prolongation of prothrombin time), neurological disorders (toxic encephalopathy and oppression central nervous system - drowsiness, confusion, convulsions, coma),disorders of the cardiovascular system (decreased blood pressure, heart rhythm disturbances, cardiac depression), respiratory disorders (hyperventilation, respiratory depression, noncardiogenic pulmonary edema, asphyxia).
With the development of such symptoms, urgent hospitalization and emergency therapy are required, including washing the gastrointestinal tract, repeated intake of activated charcoal, hemodialysis, forced alkaline diuresis, restoration of the acid-base state and water-electrolyte balance, as well as the appointment of symptomatic therapy aimed at eliminating developed violations. Forced alkaline diuresis is performed when the plasma concentration of salicylates exceeds 500 mg / l (3.6 mmol / l) in adults, 300 mg / l (2.2 mmol / l) in children. When carrying out alkaline diuresis, it is necessary to achieve pH values of 7.5–8.
special instructions
In the first trimester of pregnancy, the use of large doses of salicylates can increase the incidence of fetal defects, in particular, heart defects and cleft palate. In the last trimester of pregnancy, the use of a high dosage of Acecardol inhibits labor, causes premature closure of the ductus arteriosus in the child, and increases the likelihood of bleeding in the mother and fetus. The use of Acecardol just before childbirth can cause intracranial hemorrhage, especially in a premature baby. In this regard, the appointment of Acecardol in the I and III trimester of pregnancy is contraindicated.
In the second trimester of pregnancy, the drug is prescribed only with a strict assessment of the benefits and risks.
Influence on the ability to drive vehicles and complex mechanisms
During the course of treatment, care must be taken when driving and working with complex mechanisms.
Application during pregnancy and lactation
In the first trimester of pregnancy, salicylates in large doses increase the risk of fetal developmental defects (split palate, heart defects), therefore, Acecardol is strictly contraindicated for use.
In the second trimester of pregnancy, the drug can be prescribed only if the expected benefit is definitely higher than the potential risks. At the same time, it is recommended to use Acecardol in doses not exceeding 150 mg for the shortest possible courses.
In the third trimester of pregnancy, salicylates in large doses (more than 300 mg / day) weaken labor, cause increased bleeding in the mother and fetus and premature closure of the ductus arteriosus in the fetus. Taking ASA just before childbirth can lead to intracranial hemorrhage, especially in premature babies. In this regard, in the last trimester of pregnancy, Acecardol is strictly contraindicated for use.
Salicylates and their metabolites pass into breast milk, therefore, Acecardol is contraindicated for use in women who are breastfeeding. If the drug is clinically justified, breastfeeding should be discontinued.
Pediatric use
Acecardol is not used to treat children and adolescents under the age of 18.
With impaired renal function
- severe renal failure (creatinine clearance <30 ml / min): the use of Acecardol is contraindicated;
- impaired renal function (creatinine clearance> 30 ml / min): care must be taken during therapy.
For violations of liver function
- severe hepatic impairment (classes B and C on the Child-Pugh scale): the use of Acecardol is contraindicated;
- liver dysfunction (class A on the Child-Pugh scale): caution is required during therapy.
Drug interactions
In the case of simultaneous use, acetylsalicylic acid weakens the action of the following drugs: diuretics, angiotensin-converting enzyme (ACE) inhibitors, uricosuric drugs (benzbromarone).
In the case of simultaneous use, acetylsalicylic acid enhances the effect of the following drugs: antiplatelet agents and thrombolytic drugs, digoxin, heparin and indirect anticoagulants, methotrexate, valproic acid, hypoglycemic drugs (insulin and sulfonylurea derivatives).
Also, the combination of ASA with methotrexate is accompanied by an increased risk of adverse reactions from the hematopoietic organs, with thrombolytics, antiplatelet agents and anticoagulants - an increased risk of bleeding.
ASA enhances the toxic effect of ethanol on the central nervous system. This increases the likelihood of damage to the mucous membrane of the gastrointestinal tract and lengthening the bleeding time.
Systemic glucocorticosteroids enhance the elimination of the drug, thereby weakening its effect.
Analogs
Structural analogs of Acecardol are the drugs Trombo ACC, Aspirin, Cardiopyrin, Aspinat, Aspikor, Taspir, Trombopol, Acetylsalicylic acid.
Storage conditions and periods
Store at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Acecardol
According to reviews, Acecardol is an effective antiplatelet agent that thinns the blood and prevents blood clots. Its additional advantages include a low price (compared to most analogs), ease of administration (1 time per day), dosage form (enteric coating protects the stomach from the harmful effects of acetylsalicylic acid), as well as the presence of various dosages of tablets (50, 100 and 300 mg), which allows you to choose the most optimal one.
The disadvantages of Acecardol include the presence of contraindications. However, they are present in all salicylates, therefore, treatment should be prescribed by the attending physician.
Price for Acecardol in pharmacies
The price of Acecardol for a package containing 30 tablets varies approximately in the range of 13-25 rubles. (tablets of 50 mg), 18-33 rubles. (tablets of 100 mg), 29-49 rubles. (300 mg tablets).
Acecardol: prices in online pharmacies
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Drug name Price Pharmacy |
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Acecardol 50 mg enteric-coated tablets 30 pcs. RUB 18 Buy |
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Acecardol 100 mg enteric-coated tablets 30 pcs. RUB 23 Buy |
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Acecardol tablets p.o. enteric solution. 100mg 30 pcs. RUB 26 Buy |
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Acecardol 300 mg enteric-coated tablets 30 pcs. 28 RUB Buy |
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Acecardol 100 mg enteric-coated tablets 50 pcs. RUB 45 Buy |
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Acecardol tab. p.o ksh / solution 300mg n30 RUB 53 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
