Ampiox
Ampiox: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Ampiox
ATX code: J01CR50, J01CA51
Active ingredient: ampicillin (ampicillin) + oxacillin (oxacillin)
Producer: Bryntsalov-A, JSC (Russia)
Description and photo update: 2019-09-09
Ampiox is a combined broad-spectrum antibiotic.
Release form and composition
Dosage form - capsules: size No. 0, white; contents - granules of white or almost white color (10 pcs. in blisters and 20 pcs. in dark glass jars, in a cardboard box 2 packs or 1 can and instructions for use of Ampiox).
Active ingredients in capsules:
- ampicillin trihydrate (in terms of ampicillin) - 0.125 g;
- oxacillin sodium salt (in terms of oxacillin) - 0.125 g
Auxiliary components: sugar (sucrose), potato starch, magnesium stearate, talc, primellose.
The composition of the capsule shell: gelatin, titanium dioxide.
Pharmacological properties
Pharmacodynamics
Ampiox is a combined antibiotic that combines the spectrum of action of two active substances:
- Ampicillin: is a semi-synthetic penicillin, has a bactericidal effect, exhibits acid resistance. It is active against gram-positive, non-forming penicillinase (Streptococcus pneumoniae, Streptococcus spp., Staphylococcus spp.) And gram-negative (Neisseria meningitidis, Neisseria gonorrhoeae, Salmonella spp., Escherichia coli, Shigilella spp., Influenza miroorganizm, Shigilella spp.;
- Oxacillin: is a penicillinase-resistant semi-synthetic antibiotic from the penicillin group, showing acid resistance. Possesses bactericidal action against gram-positive microorganisms (Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus spp., Including Streptococcus pneumoniae, Bacillus anthracis, Actinomyces spp., Anaerobic spore-forming rods, including Gram-negative bacteria), including Gram-negative bacteria gonorrhoeae), K. pneumoniae, E. coli, H. influenzae, Treponema spp., Actinomyces spp., Pr. mirabilis.
Pharmacokinetics
After intramuscular administration, C max (maximum concentration) in the blood of the active substances, ampicillin and oxacillin, is reached after 30-50 minutes, after oral administration - after 90-120 minutes.
Ampicillin and oxacillin are excreted by the kidneys, in small quantities - with bile.
With repeated use, the active substances do not accumulate.
Indications for use
Ampiox capsules are prescribed for the following diseases:
- Respiratory tract and lung infections (pneumonia, bronchitis);
- Angina;
- Inflammation of the renal pelvis and kidney tissue (pyelitis, pyelonephritis);
- Inflammation of the gallbladder and bile ducts (cholecystitis, cholangitis);
- Inflammation of the bladder (cystitis);
- Infected wounds and burns, skin infections;
- Sepsis (bacterial blood poisoning);
- Postpartum infection;
- Prevention and treatment of infections in newborns;
- Prevention of purulent postoperative complications.
The use of the drug is also advisable with an unidentified antibioticogram and an unselected pathogen.
Contraindications
Ampiox capsules are not prescribed for hypersensitivity to the components of the drug, lymphocytic leukemia, infectious mononucleosis. Particular care is required when prescribing the drug to children whose mothers have an increased sensitivity to penicillin.
During pregnancy, it is possible to use Ampiox according to indications. During lactation, if it is necessary to use the drug, it is recommended to refuse breastfeeding.
Ampiox, instructions for use: method and dosage
Before starting therapy, the desired procedure is to determine the sensitivity to the drug of the microflora that caused the disease.
Ampiox is prescribed in a daily dosage:
- Adults and children over 14 years old - 2-4 g;
- Children 7-14 years old - 50 mg / kg;
- Children 3-7 years old - 100 mg / kg.
The daily dose of the drug should be divided into 4-6 doses. The average duration of treatment is 1-2 weeks.
Side effects
When using the drug, vomiting, nausea, and loose stools may occur.
Overdose
The main symptoms: toxic effect on the central nervous system, which manifests itself in the form of headache, tremors, seizures.
Therapy: drug withdrawal, emergency measures.
special instructions
During the course of treatment, the state of the functions of the kidneys, liver and hematopoietic organs should be monitored.
Application during pregnancy and lactation
- Pregnancy: the use of Ampiox is possible according to indications;
- Lactation period: it is not recommended to use the drug.
Pediatric use
Children who were born to mothers with hypersensitivity to penicillins should use Ampiox with caution.
Drug interactions
- Aminoglycosides, antacids, laxatives, glucosamine, food: slowing down and decreasing the absorption of Ampiox;
- Ascorbic acid: increased absorption of the drug;
- Bacteriostatic drugs (including lincosamides, macrolides, tetracyclines, chloramphenicol, sulfonamides): antagonistic action;
- Bactericidal antibiotics (including rifampicin, vancomycin, cephalosporins, aminoglycosides): synergistic action;
- Oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol: a decrease in their effectiveness, an increase in the likelihood of breakthrough bleeding;
- Indirect anticoagulants: increasing their effectiveness, which occurs due to the suppression of intestinal microflora, a decrease in the synthesis of vitamin K and the prothrombin index;
- Allopurinol: the likelihood of a skin rash increases;
- Probenecid, diuretics, phenylbutazone, allopurinol, non-steroidal anti-inflammatory drugs: tubular secretion decreases, the concentration of Ampiox in plasma increases, which leads to an increased risk of toxic effects.
Analogs
The analogs of Ampiox are Oxamp and Oxampicin.
Storage conditions and periods
Store in a dry, dark place at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ampiox
Reviews about Ampiox are different, although in most cases they are positive. The drug has a wide spectrum of action, but today it is rarely prescribed.
Ampiox price in pharmacies
The approximate price for Ampiox (20 capsules) is 128 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
