Ampiox - Instructions For Use, Price, Reviews, Capsule Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Ampiox

Ampiox: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Ampiox

ATX code: J01CR50, J01CA51

Active ingredient: ampicillin (ampicillin) + oxacillin (oxacillin)

Producer: Bryntsalov-A, JSC (Russia)

Description and photo update: 2019-09-09

Ampiox is a combined broad-spectrum antibiotic.

Release form and composition

Dosage form - capsules: size No. 0, white; contents - granules of white or almost white color (10 pcs. in blisters and 20 pcs. in dark glass jars, in a cardboard box 2 packs or 1 can and instructions for use of Ampiox).

Active ingredients in capsules:

• ampicillin trihydrate (in terms of ampicillin) - 0.125 g;
• oxacillin sodium salt (in terms of oxacillin) - 0.125 g

Auxiliary components: sugar (sucrose), potato starch, magnesium stearate, talc, primellose.

The composition of the capsule shell: gelatin, titanium dioxide.

Pharmacological properties

Pharmacodynamics

Ampiox is a combined antibiotic that combines the spectrum of action of two active substances:

• Ampicillin: is a semi-synthetic penicillin, has a bactericidal effect, exhibits acid resistance. It is active against gram-positive, non-forming penicillinase (Streptococcus pneumoniae, Streptococcus spp., Staphylococcus spp.) And gram-negative (Neisseria meningitidis, Neisseria gonorrhoeae, Salmonella spp., Escherichia coli, Shigilella spp., Influenza miroorganizm, Shigilella spp.;
• Oxacillin: is a penicillinase-resistant semi-synthetic antibiotic from the penicillin group, showing acid resistance. Possesses bactericidal action against gram-positive microorganisms (Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus spp., Including Streptococcus pneumoniae, Bacillus anthracis, Actinomyces spp., Anaerobic spore-forming rods, including Gram-negative bacteria), including Gram-negative bacteria gonorrhoeae), K. pneumoniae, E. coli, H. influenzae, Treponema spp., Actinomyces spp., Pr. mirabilis.

Pharmacokinetics

After intramuscular administration, C _max (maximum concentration) in the blood of the active substances, ampicillin and oxacillin, is reached after 30-50 minutes, after oral administration - after 90-120 minutes.

Ampicillin and oxacillin are excreted by the kidneys, in small quantities - with bile.

With repeated use, the active substances do not accumulate.

Indications for use

Ampiox capsules are prescribed for the following diseases:

• Respiratory tract and lung infections (pneumonia, bronchitis);
• Angina;
• Inflammation of the renal pelvis and kidney tissue (pyelitis, pyelonephritis);
• Inflammation of the gallbladder and bile ducts (cholecystitis, cholangitis);
• Inflammation of the bladder (cystitis);
• Infected wounds and burns, skin infections;
• Sepsis (bacterial blood poisoning);
• Postpartum infection;
• Prevention and treatment of infections in newborns;
• Prevention of purulent postoperative complications.

The use of the drug is also advisable with an unidentified antibioticogram and an unselected pathogen.

Contraindications

Ampiox capsules are not prescribed for hypersensitivity to the components of the drug, lymphocytic leukemia, infectious mononucleosis. Particular care is required when prescribing the drug to children whose mothers have an increased sensitivity to penicillin.

During pregnancy, it is possible to use Ampiox according to indications. During lactation, if it is necessary to use the drug, it is recommended to refuse breastfeeding.

Ampiox, instructions for use: method and dosage

Before starting therapy, the desired procedure is to determine the sensitivity to the drug of the microflora that caused the disease.

Ampiox is prescribed in a daily dosage:

• Adults and children over 14 years old - 2-4 g;
• Children 7-14 years old - 50 mg / kg;
• Children 3-7 years old - 100 mg / kg.

The daily dose of the drug should be divided into 4-6 doses. The average duration of treatment is 1-2 weeks.

Side effects

When using the drug, vomiting, nausea, and loose stools may occur.

Overdose

The main symptoms: toxic effect on the central nervous system, which manifests itself in the form of headache, tremors, seizures.

Therapy: drug withdrawal, emergency measures.

special instructions

During the course of treatment, the state of the functions of the kidneys, liver and hematopoietic organs should be monitored.

Application during pregnancy and lactation

• Pregnancy: the use of Ampiox is possible according to indications;
• Lactation period: it is not recommended to use the drug.

Pediatric use

Children who were born to mothers with hypersensitivity to penicillins should use Ampiox with caution.

Drug interactions

• Aminoglycosides, antacids, laxatives, glucosamine, food: slowing down and decreasing the absorption of Ampiox;
• Ascorbic acid: increased absorption of the drug;
• Bacteriostatic drugs (including lincosamides, macrolides, tetracyclines, chloramphenicol, sulfonamides): antagonistic action;
• Bactericidal antibiotics (including rifampicin, vancomycin, cephalosporins, aminoglycosides): synergistic action;
• Oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol: a decrease in their effectiveness, an increase in the likelihood of breakthrough bleeding;
• Indirect anticoagulants: increasing their effectiveness, which occurs due to the suppression of intestinal microflora, a decrease in the synthesis of vitamin K and the prothrombin index;
• Allopurinol: the likelihood of a skin rash increases;
• Probenecid, diuretics, phenylbutazone, allopurinol, non-steroidal anti-inflammatory drugs: tubular secretion decreases, the concentration of Ampiox in plasma increases, which leads to an increased risk of toxic effects.

Analogs

The analogs of Ampiox are Oxamp and Oxampicin.

Storage conditions and periods

Store in a dry, dark place at a temperature not exceeding 25 ° C.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Ampiox

Reviews about Ampiox are different, although in most cases they are positive. The drug has a wide spectrum of action, but today it is rarely prescribed.

Ampiox price in pharmacies

The approximate price for Ampiox (20 capsules) is 128 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!