Azithromycin-Akrikhin
Azithromycin-Akrikhin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Azithromycin-Akrihin
ATX code: J01FA10
Active ingredient: azithromycin (Azithromycin)
Producer: Micro Labs Limited (India)
Description and photo update: 2019-10-07
Prices in pharmacies: from 161 rubles.
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Azithromycin-Akrikhin is a broad-spectrum antibiotic.
Release form and composition
Dosage form - film-coated tablets: oblong, white, dosage of 500 mg - with a risk on one side (dosage of 250 mg - 6 and 10 pcs. In blisters, in a cardboard box 1 blister of 6 tablets or 10 blisters of 10 tablets, dosage of 500 mg - 3 and 10 pcs. in blisters, in a cardboard box 1 blister of 3 tablets, 1 or 10 blisters of 10 tablets. Each pack also contains instructions for the use of Azithromycin-Akrihin).
Composition of 1 tablet:
- active substance: azithromycin (in the form of a dihydrate) - 250 or 500 mg;
- auxiliary components: povidone, talc, croscarmellose sodium, calcium hydrogen phosphate, lactose, magnesium stearate, sodium lauryl sulfate, microcrystalline cellulose, colloidal silicon dioxide, corn starch;
- film shell: propylene glycol, talc, titanium dioxide, hypromellose.
Pharmacological properties
Pharmacodynamics
Azithromycin is a broad-spectrum antibacterial drug, the first representative of azalides - a new subgroup of macrolides.
The drug binds to the 50S subunit of ribosomes and inhibits peptide translocase at the translation stage, slows down the reproduction and growth of bacteria, and suppresses protein synthesis. It has a bacteriostatic effect, in high concentrations - a bactericidal effect. Acts on extra- and intracellular pathogens.
Azithromycin-Akrikhin is active against the following microorganisms:
- gram-negative bacteria: Campylobacter jejuni, Bordetella pertussis, Haemophilus influenzae, Haemophilus ducreyi, Bordetella parapertussis, Neisseria gonorrhoeae, Legionella pneumophila, Gardnerella vaginalis, Moraxella catarrhalis;
- gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Streptococcus spp. (groups C, F and G, except for those resistant to erythromycin);
- some anaerobes: Clostridium perfringens, Bacteroides bivius, Peptostreptococcus spp.;
- others: Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia trachomatis, Borrelia burgdorferi, Mycobacterium avium complex, Treponema pallidum, Ureaplasma urealyticum.
Azithromycin is ineffective for infections caused by erythromycin-resistant gram-positive bacteria.
Pharmacokinetics
After oral administration from the gastrointestinal tract, azithromycin is rapidly absorbed, since it is stable in an acidic environment and lipophilic.
After applying a dose of 500 mg, the maximum plasma concentration (C max) is 0.4 mg / l and is noted after 2.5–3 hours. Bioavailability is 37%. Azithromycin is characterized by a first pass effect through the liver.
The drug penetrates well into the respiratory tract, soft tissues and skin, organs and tissues of the urogenital tract (in particular, the prostate gland), through the histohematogenous barriers. It accumulates in a low pH environment and in lysosomes, which plays an important role in the eradication of intracellular pathogens. It is also transported by phagocytes, macrophages and polymorphonuclear leukocytes. Penetrates through cell membranes, where it creates high concentrations.
The high concentration in tissues and cells (10-50 times higher than serum) and the long half-life (T ½) of azithromycin are due to its low binding. The volume of distribution is 31.1 l / kg.
In the foci of infection, compared with healthy tissues, the drug reaches significantly higher concentrations (by 24–34%), which correlate with the severity of inflammatory edema, and remains in effective concentrations for 5–7 days after taking the last dose. Plasma proteins bind 7-50% (inverse proportion to the concentration in the blood).
Undergoes the process of demethylation in the liver with the formation of pharmacologically inactive metabolites. Plasma clearance is 630 ml / min. T ½ when taking the drug at intervals of 8-24 hours is 14-20 hours, at intervals of 24-72 hours - 41 hours, which allows you to take Azithromycin-Akrikhin 1 time per day.
It is excreted: 50% - unchanged through the intestines, 6% - by the kidneys.
Indications for use
Azithromycin-Akrikhin is used to treat diseases caused by sensitive microorganisms:
- infections of ENT organs and upper respiratory tract: sinusitis, laryngitis, tonsillitis, pharyngitis, otitis media;
- infections of the lower respiratory tract: bronchitis, pneumonia (including atypical);
- scarlet fever;
- infections of the urogenital tract: cervicitis, urethritis (including gonorrheal);
- infections of the skin and soft tissues: impetigo, erysipelas, secondarily infected dermatoses;
- the initial stage (erythema migrans) of Lyme disease (borreliosis);
- peptic ulcer of the stomach and duodenum associated with the bacterium Helicobacter pylori (as part of combination therapy).
Contraindications
Absolute:
- liver failure;
- renal failure;
- age up to 12 years;
- period of pregnancy and lactation;
- hypersensitivity to the components of the drug or other antibiotics of the macrolide group.
Azithromycin-Akrikhin should be used with caution in patients with arrhythmias, as well as in children with impaired renal and / or liver function.
Azithromycin-Akrikhin, instructions for use: method and dosage
Azithromycin-Akrikhin should be taken orally, 1 hour before meals or 2 hours after meals.
Recommended doses for adults:
- infections of the upper and lower respiratory tract: Azithromycin-Akrikhin 500 mg once a day for 3 days;
- infections of the skin and soft tissues: the first day - 1000 mg once a day, from the second to the fifth day - 500 mg once a day;
- acute urinary tract infections: 1000 mg once;
- Stage I (erythema migrans) of Lyme disease: the first day - 1000 mg, from the second to the fifth day - 500 mg once a day;
- peptic ulcer and 12 duodenal ulcer associated with Helicobacter pylori: 1000 mg 1 time per day for 3 days in addition to standard anti-Helicobacter pylori therapy.
For children from 12 years old, the dose of Azithromycin-Akrikhin is determined depending on body weight and clinical features of the disease. Possible treatment options:
- 10 mg / kg 1 time per day for 3 days.
- On the first day - 10 mg / kg, over the next 3-4 days - 5-10 mg / kg once a day (course dose - 30 mg / kg).
For the treatment of erythema migrans in children on the first day, 20 mg / kg is prescribed, from the second to the fifth day - 10 mg / kg once a day.
If the next dose is missed, the drug should be taken as soon as possible, and subsequent doses should be carried out at intervals of 24 hours.
Side effects
- digestive system: diarrhea (5%), nausea (3%), abdominal pain (3%), flatulence, vomiting, increased activity of hepatic transaminases; in children - constipation, gastritis, anorexia;
- genitourinary system: rarely - nephritis, vaginal candidiasis;
- nervous system: rarely - drowsiness, sleep disturbance, headache, anxiety, dizziness, neurosis;
- cardiovascular system: very rarely - chest pain, palpitations;
- allergic reactions: very rarely - itching, rash, angioedema;
- others: candidomycosis of the oral mucosa, increased fatigue.
Overdose
An overdose of Azithromycin-Akrikhin can manifest itself with the following symptoms: diarrhea, severe nausea, vomiting, temporary hearing loss.
After taking an excessive dose, you should rinse the stomach and take activated charcoal. Further treatment is symptomatic.
special instructions
With the simultaneous appointment of antacids, it is necessary to maintain intervals between doses of drugs in 2 hours.
After the abolition of Azithromycin-Akrikhin, in some cases, hypersensitivity reactions may persist, therefore, specific therapy is required under the supervision of a physician.
Influence on the ability to drive vehicles and complex mechanisms
In rare cases, Azithromycin-Akrikhin may cause drowsiness and dizziness. If these side effects occur, you should refrain from driving a car and performing potentially hazardous work.
Application during pregnancy and lactation
During pregnancy, Azithromycin-Akrikhin is contraindicated.
Breastfeeding should be discontinued if treatment is necessary during lactation.
Pediatric use
Azithromycin-Akrikhin is contraindicated in children under 12 years of age. It should be used with caution in the presence of concomitant functional disorders of the kidneys and / or liver.
With impaired renal function
In renal failure, antibiotic use is contraindicated.
For violations of liver function
In liver failure, the use of Azithromycin-Akrikhin is contraindicated.
Use in the elderly
There is no information on the need to adjust the dose for elderly patients.
Drug interactions
The absorption of azithromycin is reduced with the simultaneous intake of food, ethanol, antacids containing magnesium or aluminum hydroxide.
Lincosamides weaken the effect of azithromycin, while chloramphenicol and tetracycline enhance it.
With the combined use of ergotamine and dihydroergotamine, the toxic effect (dysesthesia, vasospasm) increases.
Azithromycin is pharmacologically incompatible with heparin.
At therapeutic doses, azithromycin does not affect prothrombin time (PTT) in patients receiving warfarin. However, a possible increase in the anticoagulant effect cannot be ruled out, so PTT should be carefully monitored.
The effect of azithromycin on other concomitantly used drugs:
- increases the concentration of digoxin by weakening its inactivation by the intestinal flora;
- reduces clearance and enhances the effect of triazolam;
- slows down the excretion and increases the plasma concentration and toxicity of the following drugs (by inhibiting microsomal oxidation in hepatocytes with azithromycin): indirect anticoagulants, cycloserine, felodipine, methylprednisolone, as well as agents that undergo microsomal oxidation, such as ergot alkaloids, phenyphenadic acid, valphenytoin, terp. bromocriptine, hexobarbital, carbamazepine, disopyramide, cyclosporine, theophylline and other xanthine derivatives, oral hypoglycemic drugs.
Analogs
Analogs of Azithromycin-Akrikhin are: Azibiot, Azimycin, Azitrox, ZI-Factor, Zitrolide, Sumaclid, Sumamed, Sumamox, Tremak-Sanovel, Hemomycin, etc.
Terms and conditions of storage
Store in a dry, dark place, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Azithromycin-Akrikhin
According to most reviews, Azithromycin-Akrikhin is an inexpensive but effective antibacterial agent that helps with diseases caused by sensitive microorganisms. At the same time, there are many reports in which patients complain of the development of side effects, including dizziness, drowsiness, decreased vision, tachycardia, weakness, abdominal pain, a feeling of discomfort in the intestines, candidiasis.
Price for Azithromycin-Akrikhin in pharmacies
The price of Azithromycin-Akrihin 500 mg starts at about 133 rubles. per pack of 3 film-coated tablets.
Azithromycin-Akrikhin: prices in online pharmacies
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Drug name Price Pharmacy |
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Azithromycin-Akrikhin 500 mg film-coated tablets 3 pcs. 161 r Buy |
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Azithromycin-Akrikhin tablets p.o. 500mg 3 pcs. RUB 165 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
