Furagin-LekT
Furagin-LekT: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Furagin-LekT
ATX code: J01XE03
Active ingredient: furazidin (Furazidin)
Producer: Tyumen Chemical-Pharmaceutical Plant, JSC (Russia)
Description and photo update: 2019-05-07
Prices in pharmacies: from 136 rubles.
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Furagin-LekT is an antimicrobial agent, uroantiseptic.
Release form and composition
Dosage form - tablets: flat-cylindrical, from yellow to yellow with an orange tint (10 pcs. In cell / non-cell contour packs, in a cardboard box 3 packs; 30 pcs. In cans, in a cardboard box 1 can; in each pack also contains instructions for the use of Furagin-LekT).
Composition of 1 tablet:
- active substance: furazidine - 50 mg;
- auxiliary components: calcium stearate, lactose monohydrate (milk sugar), potato starch, polysorbate-80 (tween-80), granulated sugar.
Pharmacological properties
Pharmacodynamics
Furazidin - the active component of Furagin-LekT - is a nitrofuran derivative, an antifungal agent. Effective for diseases caused by gram-positive cocci (Streptococcus spp., Staphylococcus spp.) Or gram-negative bacilli (Shigella spp., Salmonella spp., Klebsiella spp., E. coli).
Acinetobacter spp., Enterococcus spp., Plasmodium, aeruginosa, as well as most Proteus spp. Strains are resistant to furazidine. and Serratia spp.
The mechanism of action of the drug is due to its ability to inhibit the synthesis of nucleic acids. Depending on the concentration, it exhibits bactericidal or bacteriostatic activity. With regard to a large number of bacteria, the bacteriostatic concentration of furazidine is 10–20 μg / ml. The bactericidal concentration is approximately 2 times higher.
Furagin-LekT suppresses the activity of the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) in microorganisms, and also inhibits other biochemical processes, as a result of which the membrane or cytoplasmic membrane of the bacterium is destroyed.
Pharmacokinetics
After taking the drug inside, furazidine is absorbed in the distal segment of the intestine by passive diffusion.
In urine, it creates concentrations that are many times higher than bacteriostatic, the maximum is 5.7 μg / ml. Approximately 6% of the dose is excreted by the kidneys.
Indications for use
- infectious diseases of the urinary tract and kidneys: cystitis, acute and chronic pyelonephritis, urethritis, infections after surgery;
- infectious and inflammatory diseases of the respiratory tract.
Contraindications
Absolute:
- deficiency of lactase, sucrase / isomaltase, lactose / fructose intolerance, glucose-galactose malabsorption;
- severe renal failure;
- age up to 18 years;
- 38–42 weeks of pregnancy;
- lactation period;
- hypersensitivity to any component of the drug.
Relative (Furagin-LekT tablets are used with caution, under close medical supervision):
- deficiency of glucose-6-phosphate dehydrogenase;
- renal failure;
- impaired hepatic function;
- diseases of the nervous system;
- diabetes.
Furagin-LekT, instructions for use: method and dosage
Furagin-LekT tablets should be taken orally, after meals.
For medicinal purposes, the drug is prescribed at 50-100 mg 3 times a day. The duration of therapy is 7-10 days. If necessary, the course is repeated at intervals of 10-15 days.
For the prevention of infections during urological operations, catheterization and cystoscopy, the drug is used once at a dose of 50 mg 30 minutes before surgery / manipulation.
For patients with functional impairment of the kidneys, the dose is reduced.
Side effects
Furagin-LekT can cause the following side effects:
- from the digestive system: decreased appetite, anorexia, nausea, vomiting;
- from the central nervous system: dizziness;
- allergic reactions: itching, skin rash, enanthema, joint swelling, angioedema.
Overdose
Taking an excessive dose of furazidine is fraught with the development of neurotoxic reactions, including ataxia and tremor.
In this case, Furagin-LekT is canceled. The intake of a large amount of liquid and the conduct of symptomatic treatment are indicated, including the appointment of antihistamines and vitamins of group B. The specific antidote is unknown.
special instructions
To avoid the development of side effects, Furagin-LekT tablets are recommended to be taken with plenty of water. If necessary, you can reduce the dose of the drug and conduct desensitizing therapy. The most common adverse reactions are observed in patients with reduced renal excretory function.
With prolonged treatment, periodic monitoring of the level of leukocytes in the blood, kidney and liver function is necessary.
During therapy, you should refrain from drinking alcohol.
Influence on the ability to drive vehicles and complex mechanisms
In some patients, during therapy, dizziness is noted, which should be taken into account by vehicle drivers and persons employed in potentially hazardous industries that require speed of reactions and increased attention.
Application during pregnancy and lactation
Furagin-LekT is contraindicated in pregnant women during the 38-42 week period, as well as during breastfeeding.
Pediatric use
The drug is not used in pediatrics to treat children and adolescents under 18 years of age.
With impaired renal function
In case of impaired renal function, Furagin-LekT should be used with caution, correction of the dosage regimen is required.
In severe renal failure, the drug is contraindicated.
For violations of liver function
With caution, Furagin-LekT is used to treat patients with liver diseases.
Drug interactions
- nalidixic acid: the bacteriostatic effect of furazidine decreases;
- antacids, which include magnesium trisilicate: absorption of furazidine decreases;
- uricosuric drugs (probenecid, sulfinpyrazone): the excretion of furazidine in the urine and its therapeutic efficacy decrease, as a result of which the risk of accumulation of the drug in the body and an increase in its toxicity increases.
Patients should inform the doctor about all medications they are taking.
Analogs
Furagin-LekT analogs are Urofuragin, Furagin, Furagin-Aktifur, Furagin-SZ, Furamag, Furassol, etc.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C in a dark place out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Furagin-LekT
There are no reviews of Furagin-LekT on specialized forums and sites. On other drugs containing furazidine as an active substance, patients leave mostly positive reviews, noting a quick and mild action, good tolerance and affordable cost.
In rare negative messages, there are complaints about the lack of effect or the development of side reactions.
Price for Furagin-LekT in pharmacies
The approximate price for Furagin-LekT for a pack of 30 tablets of 50 mg is 211–260 rubles.
Furagin-LekT: prices in online pharmacies
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Drug name Price Pharmacy |
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Furagin-LekT 50 mg tablets 30 pcs. 136 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
