Celebrex - Instructions For Use, Indications, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Celebrex

Instructions for use:

1. 1. Pharmacological action
2. 2. Indications for use
3. 3. Instructions for use
4. 4. Side effects
5. 5. Contraindications
6. 6. Pregnancy
7. 7. Interaction with other medicinal products
8. 8. Overdose
9. 9. Release form
10. 10. Analogs
11. 11. Storage conditions
12. 12. Additional information

Prices in online pharmacies:

from 191 rub.

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Celebrex is a drug belonging to the group of non-steroidal anti-inflammatory drugs.

pharmachologic effect

Celebrex predominantly suppresses COX-2 and at the same time has a minimal effect on the activity of COX-1. The drug has anti-inflammatory, antipyretic and analgesic effects.

Experiments on animals have shown that the use of Celebrex significantly reduces the incidence of colon cancer.

According to reviews, Celebrex, to a much lesser extent than other nonsteroidal anti-inflammatory drugs, contributes to the development of gastroduodenal ulcers and related complications. These data have been confirmed by repeated endoscopic studies.

Clinical studies have also shown that the use of Celebrex in a dose of no more than 1.2 g per day does not cause changes in blood coagulation indicators.

In the instructions for Celebrex, it is noted that this drug somewhat increases the risk of developing non-fatal heart attacks and strokes, but does not affect the mortality rate from cardiovascular diseases.

Celebrex is very well absorbed from the intestines. The maximum concentration in the blood is reached two hours after ingestion of the drug. Fatty foods impair absorption of this drug. Excreted in bile.

With the appointment of therapeutic doses of Celebrex, higher concentrations of this drug in the blood are noted in women, patients with low body weight and representatives of the Negroid race. Therefore, these categories of patients begin treatment with minimal doses.

According to reviews of Celebrex, in some cases it can lead to a decrease in the excretion of sodium in the urine, which leads to the development of peripheral edema. However, no increase in blood pressure was observed. These edemas do not require treatment and will go away on their own.

In the course of the studies, the embryotoxic and teratogenic effects of the drug were not revealed.

Indications for use

This drug can be used as a symptomatic agent in the complex therapy of the following diseases:

• Spondylitis;

• Deforming osteoarthritis;

• Rheumatoid arthritis;

• Algodismenorrhea.

The indication for Celebrex is also a pronounced pain syndrome, the development of which is caused by injuries, surgical interventions and other reasons.

According to the instructions, Celebrex can be used for complex therapy of patients suffering from familial adenomatous polyposis. The use of Celebrex in this case helps to reduce the size and total number of colorectal adenomatous polyps.

Instructions for use

It is recommended to take this drug 200 mg twice a day. Considering that the development of complications from the cardiovascular system directly depends on the dosage of this drug, Celebrex should be administered in short courses and in the minimum effective dose.

With arthritis and other joint diseases, the daily dose of Celebrex can be increased to 800 mg per day.

For acute pain, 600 mg of Celebrex is initially prescribed, then 200 mg is given every 12 hours.

With familial adenomatous polyposis, the drug is prescribed twice a day, 400 mg.

When prescribing Celebrex to elderly patients weighing less than 50 kg, it is necessary to reduce the dosage.

Indications for Celebrex should be carefully evaluated in patients with severe hepatic impairment. If it is necessary to prescribe this drug, its dosage in this category of patients should be reduced by 50%.

Side effects

• Allergic reactions;

• Thrombocytopenia;

• Anxiety;

• Heart rhythm disorders;

• Arterial hypertension;

• Noise in ears;

• Alopecia.

According to reviews, Celebrex rarely leads to an increase in the activity of hepatic transaminases and the development of pancreatitis.

With prolonged (more than 3 years) use of Celebrex, the following may develop:

• Arterial hypertension;

• Non-systemic fungal infections;

• Stool disorders;

• Coronary heart disease;

• Ear infections;

• Dysphagia and nausea;

• Prostatitis;

• Formation of calculi (stones) in the kidneys;

• Increased serum creatinine.

Contraindications

• Individual intolerance to the drug;

• Allergic reactions to sulfonamides.

Also, Celebrex should not be prescribed to relieve pain after coronary artery bypass grafting.

Pregnancy

Indications for Celebrex in pregnant women should be carefully evaluated by doctors. This drug can be prescribed only if the expected benefit from the therapy is significantly greater than the potential risk of developing pathology in the fetus.

In the last trimester of pregnancy, Celebrex is contraindicated, because it can disrupt the contractile activity of the uterus during labor and lead to premature closure of the oval window.

Interaction of Celebrex with other drugs

Celebrex should not be administered concurrently with indirect anticoagulants and other non-steroidal anti-inflammatory drugs, because this increases the risk of bleeding. Celebrex reduces the antihypertensive effect of angiotensin II blockers.

Overdose

There is no specific antidote, therefore, symptomatic therapy is carried out for treatment, aimed at maintaining vital functions and accelerating the elimination of Celebrex from the patient's body.

Release form

Celebrex is available in capsules containing 100 and 200 mg of the active substance (Celecoxib). The capsules are packed in blisters of 10 and 20 pieces.

Analogs of Celebrex

Other medicinal substances (analogs of Celebrex) have a similar therapeutic effect with this drug: Celecoxib, Revmoxib, Phlogoxib-Health, Ranselex. Analogs of Celebrex have exactly the same indications and contraindications to the appointment, as well as Celebrex itself.

Storage conditions

Celebrex should be stored in a dry place out of the reach of children at room temperature.

Additional Information

According to reviews, Celebrex can lead to an increased risk of thrombus formation, so it is advisable for them to carry out therapy with minimal doses and for a short period. The drug has no antiplatelet properties and cannot replace acetylsalicylic acid (Aspirin).

The instructions for Celebrex emphasize that during treatment it is necessary to control the level of blood pressure, especially in elderly patients.

This medicinal product should not be used in pediatric practice, because there is currently not enough evidence for its safe use in children.

Celebrex penetrates well into breast milk and can become hazardous to the health of the baby. Therefore, for the period of treatment, it is necessary to stop breastfeeding.

Celebrex: prices in online pharmacies

Drug name Price Pharmacy

Celebrex 400 mg + 200 mg capsule set 6 pcs. 191 r Buy

Celebrex capsules 400mg No. 1 + 200mg 5 pcs. 202 RUB Buy

Celebrex 100 mg capsules 10 pcs. RUB 350 Buy

Celebrex capsules 200mg 10 pcs. 441 r Buy

Celebrex 200 mg capsule 10 pcs. 441 r Buy

Celebrex capsules 100mg 10 pcs. 535 RUB Buy

Celebrex capsules 200mg 30 pcs. 1135 RUB Buy

Celebrex 200 mg capsule 30 pcs. 1135 RUB Buy

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!