Cellex - Instructions For Use, Price, Reviews, Analogues

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Cellex - Instructions For Use, Price, Reviews, Analogues
Cellex - Instructions For Use, Price, Reviews, Analogues

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Video: Cellex - Instructions For Use, Price, Reviews, Analogues
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Cellex

Cellex: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. Drug interactions
  12. 12. Analogs
  13. 13. Terms and conditions of storage
  14. 14. Terms of dispensing from pharmacies
  15. 15. Reviews
  16. 16. Price in pharmacies

Latin name: Cellex

ATX code: N06BX

Active ingredient: polypeptides from the brain of pig embryos

Producer: LLC "Company" DEKO "(Russia), CJSC" Pharm-Sintez "(Russia)

Description and photo update: 2018-21-11

Prices in pharmacies: from 6520 rubles.

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Cellex solution for subcutaneous administration
Cellex solution for subcutaneous administration

Cellex is a neuroprotective nootropic drug.

Release form and composition

Dosage form - solution for subcutaneous administration: clear liquid of light yellow color or colorless with a characteristic odor or odorless; the presence of separate threads of coagulum is allowed; opalescence is allowed (in dark glass ampoules of 1 or 2 ml, in a blister contour packaging made of polyvinyl chloride film 1, 2 or 5 ampoules, in a cardboard box 1 or 2 packages complete with sterile syringe filters with a pore size of 0.22 microns in an amount equal to the number of ampoules).

Composition of 1 ml solution:

  • active substance: Cellex substance-solution (frozen, in terms of protein *) - 0.1 mg;
  • auxiliary components: glycine, sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate monohydrate, sodium chloride, water for injection.

* Composition for 1 ml:

  • active substance: polypeptides from the brain of pig embryos in terms of total protein - 0.9–2.4 mg (nominal total protein content of 1.65 mg per 1 ml of substance);
  • excipients: glycine, disodium hydrogen phosphate, sodium chloride, polysorbate-80, purified water.

Pharmacological properties

Pharmacodynamics

The direct neuroreparative effect of Cellex is due to the presence of tissue-specific receptor proteins and polypeptides in the preparation, which are factors of growth and differentiation of nerve cells. The mechanism of action is to regulate the concentration of the pool of biologically active neurotransmitters and inhibit the diffusion of excitatory amino acids.

By stimulating the process of synaptogenesis, restoring autophagy signals, increasing tissue immunoregulation, and inhibiting the immunogenic cytotoxicity of macrophages, Cellex promotes the activation of secondary neuroprotection. The drug has a tissue-specific and systemic reparative effect, restoring the regenerative and reparative potential of brain cells, improving microcirculation and general perfusion and reducing the number of damaged cells and the severity of perifocal edema in the penumbra area, which significantly limits the focus of brain tissue necrosis.

Due to the restoration and regulatory stimulation of various compartments of the central nervous system with a systemic effect of growth factors, differentiation and neurotransmitters, as a result of the use of Cellex, there is a decrease in the recovery and rehabilitation periods in case of damage to the central and peripheral nervous system of vascular origin, as well as restoration of sensory, motor and cognitive functions. The therapeutic effect of the drug, as a rule, develops within 3-5 days from the beginning of its administration.

Pharmacokinetics

Cellex has a complex composition, its active fraction includes a balanced and stable mixture of biologically active proteins and polypeptides, which have a total multifunctional effect, which makes it difficult to carry out the usual pharmacokinetic analysis of individual components of the drug.

Indications for use

  • cerebrovascular diseases;
  • disorders of cerebral circulation in the acute phase and in the early rehabilitation period of the course of the disease (as part of complex therapy).

Contraindications

Absolute:

  • manic psychosis;
  • epilepsy;
  • delirium;
  • productive delirium;
  • age up to 18 years.

Relative (Cellex's appointment requires special care):

  • arterial hypertension of a malignant course in the phase of decompensation;
  • sympathoadrenal crises like panic attacks;
  • severe anxiety-depressive disorders;
  • a history of allergic reactions to protein-peptide drugs.

Instructions for the use of Cellex: method and dosage

Cellex solution is injected subcutaneously through a sterile syringe filter with a pore size of 0.22 μm, which is included in the kit.

Method of administration: a solution is drawn into the syringe in the required amount, the needle is removed, then a sterile syringe filter and a new needle are put on the syringe. The preparation is ready to use.

Adults are recommended to inject Cellex at a dose of 0.1–0.2 mg subcutaneously once a day for 10 days, depending on the severity of the patient's condition. If necessary, it is possible to repeat the course in 10 days.

Side effects

During treatment, hypersensitivity reactions (itching, skin rash, angioedema), headache, sleep disturbance, subfebrile condition, as well as allergic reactions in the form of unexpressed hyperemia at the injection site may occur.

Overdose

At this time, there is no information on overdose.

special instructions

The preparation does not contain prion infections and viruses.

Influence on the ability to drive vehicles and complex mechanisms

There are currently no data on the effect of Cellex on the ability to drive transport and perform work requiring high concentration of attention and speed of motor / mental reactions.

Application during pregnancy and lactation

It is not recommended to use the drug in pregnant and breastfeeding women, since no relevant studies have been conducted.

Pediatric use

According to the instructions, Cellex is contraindicated for use in children and adolescents under 18 years of age due to insufficient clinical data.

Drug interactions

With the simultaneous use of Cellex with psychostimulant drugs and alcohol, sleep disturbance, psychomotor agitation can be observed.

In the case of joint use with Cellex, a decrease in the activity of tranquilizers, anesthetics, antipsychotics is possible.

Analogs

Cellex analogs are Cerebrolysate and Cerebrolysin.

Terms and conditions of storage

Store in a dark place at a temperature of 2 to 8 ° C.

Keep out of the reach of children.

Shelf life is 1 year.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews of Cellex

Judging by the reviews about Cellex, it often helps restore movement in patients after a stroke. The effect usually occurs after several days of regular administration of the drug. There are practically no complaints about side effects.

Users note, however, that Cellex is expensive and is not always available in pharmacies.

The price of Cellex in pharmacies

On average, the price for Cellex is about 7,000 rubles for a package of 5 ampoules.

Cellex: prices in online pharmacies

Drug name

Price

Pharmacy

Cellex 0.1 mg / ml solution for subcutaneous administration 1 ml 5 pcs.

6520 RUB

Buy

Cellex s / c solution 0.1 mg / ml 1 ml 5 pcs + syringe filters erased 5 pcs

RUB 7407

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Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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