Flamax forte
Flamax forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Flamax forte
ATX code: M01AE03
Active ingredient: ketoprofen (ketoprofen)
Manufacturer: Replekpharm A. O. (Republic of Macedonia), Sotex PharmFirma (Russia)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 129 rubles.
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Flamax forte is a non-steroidal anti-inflammatory drug (NSAID).
Release form and composition
Dosage form Flamax forte - film-coated tablets: blue, biconvex, round (in blisters of 10 pcs., In a cardboard box 2 blisters).
Composition of 1 tablet:
- active substance: ketoprofen - 0.1 g;
- auxiliary components: brilliant blue, titanium dioxide, talc, macrogol 6000, hypromellose, colloidal silicon dioxide, sodium lauryl sulfate, magnesium stearate, microcrystalline cellulose, povidone, croscarmellose sodium, rice starch, lactose monohydrate.
Pharmacological properties
Pharmacodynamics
Flamax forte has antiaggregatory, antipyretic, analgesic and anti-inflammatory properties, and exhibits antibradykinin activity. The drug inhibits the activity of cyclooxygenase-1 (COX-1) and COX-2, which regulate the synthesis of prostaglandins, stabilizes lysosomal membranes.
The tablets have an analgesic effect, which is due to both central and peripheral mechanisms.
Pharmacokinetics
Pharmacokinetic characteristics of ketoprofen:
- absorption: quickly absorbed; bioavailability is 90%; With max (maximum concentration in blood plasma) is achieved after ½ – 2 hours after administration due to low Vd (volume of distribution); absolute bioavailability varies within 64–80%; food intake has no effect on its absorption; equilibrium concentration (Css) in plasma is reached after 1 day after the start of regular intake; With max in synovial fluid - 30% of the concentration in serum, after 4-6 hours it increases; well penetrates into connective tissues and synovial fluid; penetrates the blood-brain barrier;
- distribution: Vd - 0.1–0.2 l per 1 kg; almost 99% of absorbed ketoprofen binds to proteins (mainly albumin);
- metabolism: through glucuronidation, it is almost completely metabolized in the liver; has the effect of the first passage through the liver;
- excretion: mainly excreted by the kidneys and intestines (1–8%); T 1/2 (half-life) varies from 1.6 to 1.9 hours; T 1/2 in elderly patients increases to 3-5 hours, in patients with renal insufficiency - approximately 3.5 hours; does not cumulate.
Indications for use
According to the instructions, Flamax forte is used to treat inflammatory and degenerative pathologies of the musculoskeletal system:
- pain syndrome;
- toothache and headache;
- post-traumatic and postoperative pain syndrome, accompanied by inflammation;
- oncological diseases;
- algodismenorrhea;
- arthritis: rheumatoid, psoriatic, gouty;
- ankylosing spondylitis (ankylosing spondylitis);
- osteoarthritis;
- radiculitis, tendinitis, bursitis;
- otitis;
- adnexitis;
- myalgia, neuralgia, arthralgia, ossalgia.
Contraindications
Absolute:
- hemophilia and other blood clotting disorders;
- insufficiency of the circulatory system;
- severe hepatic / renal failure;
- cerebrovascular, gastrointestinal and other bleeding (or suspicion of them);
- a history of bronchial asthma, the development of which was the use of ketoprofen, another NSAID, including acetylsalicylic acid;
- peptic ulcer;
- diverticulitis, Crohn's disease, ulcerative colitis;
- recurrent peptic ulcer of the stomach and duodenum;
- age under 15;
- pregnancy;
- lactation period;
- individual intolerance to the components contained in the drug.
Relative (diseases / conditions in the presence of which the appointment of Flamax Forte requires caution): hepatic and renal failure, alcoholic cirrhosis of the liver, alcoholism, tobacco smoking, chronic heart failure, coronary heart disease, dehydration, edema, blood pathologies (including leukopenia), diabetes mellitus, history of gastrointestinal ulcers, bronchial asthma, anemia, arterial hypertension, hyperbilirubinemia, sepsis, stomatitis, adolescence from 15 to 18 years, old age.
Instructions for the use of Flamax forte: method and dosage
Flamax forte tablets are taken orally, along with food.
The adult dose is 1 pc. 2-3 times a day every 8 hours. The maximum dose is 3 pcs. in a day.
Side effects
- digestive system: hepatitis, increased activity of hepatic transaminases in blood serum, hemorrhoidal / gastrointestinal / gingival bleeding, ulceration and perforation of the gastrointestinal mucosa, taste changes, stomatitis, dyspepsia, abdominal pain, NSAID-gastropathy;
- nervous system: peripheral neuropathy, migraine, forgetfulness, confusion or loss of consciousness, asthenia, depression, drowsiness, nervousness, agitation, insomnia, dizziness, headache;
- sensory organs: vertigo, hearing loss, conjunctival hyperemia, eye pain, dryness of the mucous membrane of the eye, conjunctivitis, blurred vision, noise or ringing in the ears;
- cardiovascular system: tachycardia, increased blood pressure;
- blood and hematopoietic organs: rarely - leukopenia, thrombocytopenia, hemolytic anemia, agranulocytosis, anemia;
- urinary system: hematuria, nephrotic syndrome, interstitial nephritis, impaired renal function, urethritis, cystitis, edematous syndrome;
- respiratory organs: shortness of breath, nosebleeds, laryngeal edema, rhinitis, bronchospasm, dyspnea, hemoptysis;
- skin: photodermatitis, toxic epidermal necrolysis (Lyell's syndrome), exudative erythema (including Stevens-Johnson syndrome), alopecia, eczema, skin rash;
- allergic reactions: anaphylactic shock, exfoliative dermatitis, angioedema, rhinitis, itching of the skin, skin rash (including urticaria, erythematous rash);
- others: vaginal bleeding, thirst, muscle twitching, myalgia, increased sweating.
Overdose
In case of an overdose, it is possible to develop abdominal pain, vomiting, nausea, drowsiness, impaired renal and liver function, and bleeding.
Therapy: symptomatic treatment, including gastric lavage and / or intake of activated charcoal (or other sorbents).
special instructions
Strict medical supervision is required when combined therapy with ketoprofen with coumarin anticoagulants (including warfarin), lithium salts.
During the period of application of the drug in patients with a history of ulcerative pathologies of the gastrointestinal tract, renal / hepatic insufficiency, control the picture of peripheral blood and the functional state of the liver and kidneys.
Reducing the dose of the drug and careful medical supervision is required when prescribing Flamax forte to patients with impaired liver and kidney function.
The drug is discontinued 48 hours before the determination of 17-ketosteroids.
The drug, like other drugs in this group, can mask the signs of infectious diseases.
In cases of development of violations of the organ of vision, it is recommended to contact an ophthalmologist for advice.
Influence on the ability to drive vehicles and complex mechanisms
It is important for patients during the period of taking Flamax forte to be careful when driving and conducting potentially hazardous activities.
Application during pregnancy and lactation
Flamax forte is contraindicated for use during pregnancy and lactation.
Pediatric use
- under 15 years of age: use is contraindicated;
- from 15 to 18 years: appoint with caution.
With impaired renal function
- severe renal failure: use is contraindicated;
- renal failure: appoint with caution.
For violations of liver function
- severe hepatic impairment: use is contraindicated;
- hepatic failure: appoint with caution.
Use in the elderly
Flamax forte is prescribed with caution to elderly patients.
Drug interactions
The effect of ketoprofen on drugs / substances in combined use:
- uricosuric, antihypertensive drugs, diuretics: reduces their effectiveness;
- ethanol, fibrinolytics, antiplatelet agents, anticoagulants, estrogens, mineralocorticosteroids, glucocorticosteroids: enhances their effect;
- oral hypoglycemic agents, insulin: increases their hypoglycemic effect;
- lithium preparations, nifedipine, verapamil: increases their plasma concentration.
The effect of drugs / substances on ketoprofen in combination therapy:
- tricyclic antidepressants, phenylbutazone, rifampicin, barbiturates, ethanol, phenytoin (inducers of microsomal oxidation in the liver): increase the production of its hydroxylated active metabolites;
- cholestyramine, antacids: reduce its absorption;
- myelotoxic drugs: increase the manifestations of its hematotoxicity.
With the simultaneous use of ketoprofen with other NSAIDs, corticotropin, ethanol, glucocorticosteroids, ulceration, the development of gastrointestinal bleeding, an increased risk of renal dysfunction is possible; with sodium valproate - violation of platelet aggregation; with cefotetan, cefamandol, cefoperazone, antiplatelet agents, thrombolytics, heparin, oral anticoagulants - an increased risk of bleeding.
Analogs
Flamax forte analogues are: Flexen, Profenid, OKI, Ketoprofen, Ketonal, Bystrumkaps, Artrum, Artrozilen and others.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Flamax Fort
According to reviews, Flamax Forte is an effective drug with a pronounced analgesic effect. Taking the pills greatly relieves the condition after the operation.
Price for Flamax forte in pharmacies
The approximate price of Flamax forte film-coated tablets (20 per pack) is 140 rubles.
Flamax forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Flamax forte 100 mg film-coated tablets 20 pcs. 129 RUB Buy |
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Flamax Forte tablets p.o. 100mg 20 pcs. 133 rbl. Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
