Phlebopress
Phlebopress: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Flebopress
ATX code: C05CA04
Active ingredient: troxerutin (Troxerutin)
Manufacturer: OOO Ozon Pharm (Russia); LLC "Ozon" (Russia)
Description and photo updated: 2020-19-03
Prices in pharmacies: from 251 rubles.
Buy
Phlebopress is a venotonic and venoprotective drug used for circulatory disorders; angioprotector.
Release form and composition
Phlebopress is produced in capsules: gelatinous, solid, opaque, size No. 0, body - light yellow with a brown tint, lid - light purple; the contents of the capsules are a mixture of powder and granules or granular powder from yellow to greenish-yellow color, its clumping is possible (10 or 30 capsules each in blister contour packages made of PVC film and varnished printed aluminum foil, in a carton box 1, 2, 3, 5, 6, 10 packs; 10, 20, 30, 50, 60 or 100 capsules each in polypropylene / polyethylene terephthalate cans, sealed with polypropylene lids with a push-turn system or low / high pressure polyethylene lids with first opening control, in a pack of cardboard 1 can. Each pack also contains instructions for the use of Phlebopress).
Composition of 1 capsule:
- active ingredient: troxerutin - 300 mg;
- additional substances: milk sugar (lactose monohydrate), magnesium stearate, sodium carboxymethyl starch;
- capsule body: gelatin, titanium dioxide, dyes - iron oxide yellow and iron oxide red;
- capsule cap: gelatin, titanium dioxide, dyes - charming red and brilliant blue.
Pharmacological properties
Pharmacodynamics
Troxerutin is a semi-synthetic bioflavonoid (rutin derivative) belonging to the benzopyran class, which exhibits P-vitamin activity, has venotonic, angioprotective, anti-inflammatory and decongestant properties. The drug reduces capillary fragility and permeability.
The pharmacodynamic properties of troxerutin are due to the participation of its bioflavonoids in redox processes and suppression of hyaluronidase. By exerting an influence on it, troxerutin stabilizes the hyaluronic acid of the cell membranes and reduces their permeability. It exhibits antioxidant activity, which prevents the oxidation of ascorbic acid, lipids and adrenaline. In addition, it reduces capillary fragility and permeability, prevents damage to the basement membrane of endothelial cells in the event of exposure to various factors. Phlebopress helps to increase the density of the vascular wall, reduce diapedesis of blood cells and exudate the liquid part of the plasma. Due to the action of troxerutin, exudative inflammation in the vascular wall decreases, and platelet adhesion to its surface decreases. Besides,the drug inhibits aggregation and increases the degree of erythrocyte deformation.
The use of Phlebopress is equally effective in the initial and late stages of the treatment of chronic venous insufficiency. The drug can be used as one of the components of complex therapy. The use of an angioprotector helps to reduce swelling and a feeling of heaviness in the legs, reduce the intensity of cramps and pain, improve tissue trophism, and alleviate symptoms associated with hemorrhoids - pain, exudation, itching, bleeding.
Acting on the resistance and permeability of the capillary walls, troxerutin slows down the progression of diabetic retinopathy, and its ability to influence the rheological properties of blood prevents the development of retinal vascular microthrombosis.
Pharmacokinetics
Pharmacokinetic characteristics of troxerutin:
- absorption and distribution: when taken orally, troxerutin is rapidly absorbed. The maximum concentration of the substance in the blood plasma (C max) is established on average 1.75 ± 0.46 hours after ingestion. Absorption is approximately 10-15%. With an increase in the dose, the bioavailability of the drug increases. The therapeutic concentration of the agent in the blood plasma is maintained for 8 hours. Half an hour after administration, the second peak of troxerutin concentration in the blood plasma occurs, which is due to enterohepatic recirculation;
- metabolism: Troxerutin is partially metabolized in the liver to form trihydroethyl quercitin and glucuronide;
- excretion: excreted mainly through the intestines (up to 65–70%), to a lesser extent - by the kidneys (up to 25%) unchanged. The half-life (T 1/2) is 6.77 ± 2.37 hours.
Indications for use
Phlebopress is used as part of the complex therapy of the following conditions / diseases:
- chronic venous insufficiency;
- trophic ulcers and trophic disorders in chronic venous insufficiency;
- superficial periphlebitis / thrombophlebitis;
- phlebeurysm;
- diabetic retinopathy / angiopathy;
- post-thrombotic syndrome;
- hemorrhoids (to relieve symptoms)
- post-traumatic edema and soft tissue hematomas.
In addition, Phlebopress capsules are used after sclerotherapy and / or removal of varicose veins of the lower extremities as a means of auxiliary therapy.
Contraindications
Absolute:
- chronic gastritis in the acute phase;
- peptic ulcer of the stomach and / or duodenum;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome;
- I trimester of pregnancy;
- lactation period (breastfeeding);
- age up to 18 years (due to lack of sufficient experience in application);
- hypersensitivity to troxerutin or one or more auxiliary components that make up the drug.
With caution, it is recommended to prescribe Phlebopress to patients with chronic renal failure (if there is a need for prolonged use of an angioprotector).
Phlebopress, instructions for use: method and dosage
Phlebopress capsules are taken orally during meals, swallowing whole and drinking plenty of water.
The initial dose of the drug is 1 capsule (300 mg) 3 times a day. As a rule, the effect develops within 14 days. In the future, therapy is continued at the same dose or reduced to the average therapeutic dose - 1 capsule 2 times a day (600 mg). In some cases, treatment is suspended (the effect achieved by this time remains for at least 4 weeks). If necessary, after consulting a specialist, you can increase the dose. The duration of the course is on average 21-28 days.
The dose of Phlebopress for maintenance therapy is 1 capsule (300 mg) per day for 21–28 days.
Dose for diabetic retinopathy - 2 capsules 3 times a day (single dose - 600 mg, daily - 1800 mg). The duration of the therapeutic course is on average 21-28 days. The decision on the need for longer treatment is determined individually for each patient and after consultation with a doctor.
Side effects
Troxerutin is very well tolerated; in rare cases, mild adverse reactions may occur.
Possible side effects from systems and organs when taking Phlebopress capsules:
- central nervous system: headache;
- digestive system: erosive and ulcerative lesions of the gastrointestinal tract, stomach pain, vomiting, nausea, diarrhea, flatulence;
- cardiovascular system: flushing of the face;
- skin and subcutaneous tissues: pruritus, skin rash, erythema;
- immune system: hypersensitivity reactions.
In case of aggravation of any of the above side effects or the appearance of new ones, you should immediately inform your doctor.
Overdose
Troxerutin is a substance with very low toxicity. In case of overdose, headache, nausea, agitation, flushing of the face may occur.
To relieve symptoms, you should rinse the stomach, take activated charcoal. These measures are relevant within an hour after taking the drug. If necessary, symptomatic and supportive therapy is prescribed.
If you suspect an overdose of Phlebopress, you should immediately seek medical help.
special instructions
In the treatment of deep vein thrombosis or superficial thrombophlebitis while taking the drug, it is possible to use anti-thrombotic and anti-inflammatory therapy.
Phlebopress has no therapeutic effect in edema caused by concomitant diseases of the heart, liver or kidneys.
If the patient uses the drug on his own, it is important to comply with the recommended dosage regimen and not exceed the maximum treatment times and the doses indicated in the instructions.
If the severity of symptoms persists during the period of use of the drug or if they worsen, it is necessary to urgently seek medical advice.
Influence on the ability to drive vehicles and complex mechanisms
Reception of Phlebopress does not affect the psychophysiological reactions of a person, therefore, it does not interfere with driving and other complex mechanisms.
Application during pregnancy and lactation
In the course of experimental studies, fetotoxicity and teratogenicity of preparations containing troxerutin were not observed. Studies on the fetotoxicity and teratogenicity of Phlebopress in humans have not been carried out, but there is data indicating a possible relationship between troxerutin intake during gestation and anomalies in the structure of the outer ear in children.
It is strictly contraindicated to take Phlebopress to women during the first trimester of pregnancy. In the II and III trimesters, the possibility of using the drug is determined by the doctor, and is allowed only if the intended benefit to the mother is significantly higher than the potential risk to the fetus. If you need to take Phlebopress capsules during the II and III trimesters of pregnancy, you should definitely consult a specialist.
There is no data on the penetration of troxerutin into breast milk, therefore, taking the drug for women who are breastfeeding is contraindicated.
Pediatric use
Phlebopress is contraindicated in patients under 18 years of age (due to the lack of sufficient experience in this age group).
With impaired renal function
It is recommended to prescribe Phlebopress with caution to patients with chronic renal failure (especially if long-term use of an angioprotector is necessary).
For violations of liver function
There are no special instructions for the use of the drug in patients with impaired hepatic function.
Use in the elderly
There are no special instructions for the use of Phlebopress in elderly patients.
Drug interactions
Joint reception with ascorbic acid enhances its effect on the resistance and permeability of the vascular wall.
Analogs
Phlebopress analogs are Troxevasin, Troxerutin, Troxerutin Velpharm, Troxerutin VERTEX, Troxerutin Vramed, Troxerutin Sanofi, Troxerutin MIK, Troxerutin Zentiva, etc.
Terms and conditions of storage
Keep out of the reach of children. Store at a temperature not exceeding 25 ° C.
The shelf life is 3 years. After the expiration date indicated on the package, it is prohibited to use the drug.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Phlebopress
There are no reviews on Phlebopress on the Internet, therefore, it is not possible to assess the degree of its effectiveness as a venotonic and venoprotective drug.
Price for Phlebopress in pharmacies
The price of Phlebopress, 300 mg capsules, in pharmacy chains is from 270 rubles. for 30 pcs. in the package and from 350 rubles. for 60 pcs. packaged.
Phlebopress: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Phlebopress capsules 300mg 30pcs 251 RUB Buy |
|
Phlebopress 300 mg capsules 30 pcs. 251 RUB Buy |
|
Phlebopress 300 mg capsules 60 pcs. 328 RUB Buy |
|
Phlebopress capsules 300mg 60pcs 386 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
