Tsefekon D
Latin name: Cefecon D
ATX code: N02BE01
Active ingredient: Paracetamol (Paracetamol)
Producer: Nizhpharm, JSC (Russia)
Description and photo update: 2018-23-10
Prices in pharmacies: from 29 rubles.
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Cefekon D is a drug with analgesic and antipyretic effects, used in children under 12 years of age.
Release form and composition
Dosage form Tsefekon D - rectal suppositories for children: torpedo-shaped, white or white with a creamy or yellowish tinge (5 pcs. In blisters, in a cardboard box 2 packs).
Composition of 1 suppository:
- active substance: paracetamol - 50, 100 or 250 mg;
- additional component: solid fat (supposir, witepsol) - until a suppository weighing 1250 mg is obtained.
Pharmacological properties
Pharmacodynamics
Cefekon D has an analgesic and antipyretic effect.
Paracetamol, acting on the centers of pain and thermoregulation, blocks cyclooxygenase in the central nervous system. Cellular peroxidases in the inflammation focus neutralize the effect of paracetamol on cyclooxygenase. This explains the lack of a pronounced anti-inflammatory effect.
Cefekon D has no negative effect on water-electrolyte metabolism and the mucous membrane of the gastrointestinal tract.
Pharmacokinetics
Paracetamol is rapidly and highly absorbed from the gastrointestinal tract. C max (maximum concentration of the substance) is reached after 30-60 minutes. Plasma protein binding is 15%. Penetrates the blood-brain barrier.
Metabolized in the liver. 80% of the substance reacts with glucuronic acid and sulfates, resulting in the formation of inactive metabolites. 17% of paracetamol undergoes hydroxylation with the formation of active metabolites, which are subsequently conjugated with glutathione and form inactive metabolites. These metabolites, in case of a lack of glutathione, can block the enzyme systems of hepatocytes and lead to the development of necrosis. T 1/2 (half-life) - from 2 to 3 hours. 85–95% of paracetamol is excreted by the kidneys within 24 hours in the form of sulfates and glucuronides, unchanged - about 3%.
V d (volume of distribution) and bioavailability in children (including neonates) are similar to those in adult patients. The main metabolite of paracetamol in newborns during the first 2 days of life and in children 3–10 years old is paracetamol sulfate, in children over 12 years old - conjugated glucuronide. There is no significant age-related difference in the rate of elimination of paracetamol and in the total amount of substance excreted in the urine.
Indications for use
- acute respiratory viral infection, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature - as an antipyretic agent;
- pain syndrome of mild / moderate intensity, including headache, toothache, muscle pain, neuralgia, pain in burns and injuries - as a pain reliever.
Contraindications
Absolute:
- age up to 1 month;
- individual intolerance to the components of the drug.
Relative (Tsefekon D is prescribed under medical supervision):
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- functional disorders of the kidneys and liver;
- diseases of the blood system (thrombocytopenia, anemia, leukopenia);
- syndromes of Gilbert, Dubin - Johnson, Rotor.
Instructions for the use of Cefekon D: method and dosage
Cefekon D is used rectally. Suppositories should be injected into the rectum after a cleansing enema or spontaneous bowel movement.
The scheme of application is set depending on age and weight. The average single dose is 10-15 mg / kg, the frequency of use is 2-3 times a day (observing the intervals of 4-6 hours). The maximum dose is 60 mg / kg per day.
Recommended single doses:
- 1-3 months (4-6 kg): Tsefekon D 50 mg (the drug can be administered once after vaccination to lower the temperature, the possibility of its use in other cases is determined by the doctor);
- 3–12 months (7–10 kg): Cefecon D 100 mg;
- 1-3 years (11-16 kg): 100-200 mg;
- 3-10 years (17-30 kg): Tsefekon D 250 mg;
- 10-12 years (31-35 kg): 500 mg.
As an antipyretic agent, Tsefekon D can be used for 3 days, as an anesthetic - 5 days. The duration of use should not be increased without the agreement of a doctor.
Side effects
- digestive system: vomiting, nausea, abdominal pain;
- hematopoietic system: rarely - leukopenia, thrombocytopenia, anemia, agranulocytosis;
- allergic reactions: urticaria, itching, rash on the mucous membranes and skin, Quincke's edema.
During a long course with high doses, aplastic / hemolytic anemia, methemoglobinemia, pancytopenia, hepatotoxic and nephrotoxic (papillary necrosis and interstitial nephritis) effects may occur.
Overdose
There is no information.
special instructions
If symptoms persist after a course of therapy, you should consult a specialist.
With the quantitative determination of uric acid and glucose in plasma, paracetamol can distort laboratory tests.
Combined use with other paracetamol-containing drugs should be avoided, as this can lead to an overdose of paracetamol.
When conducting a long course, it is necessary to monitor the functional state of the liver and peripheral blood parameters.
Pediatric use
According to the instructions, Tsefekon D is intended for use in children from 3 months to 12 years old. For children 1-3 months, the drug can be administered once after vaccination to reduce fever.
With impaired renal function
Therapy in the presence of impaired renal function should be carried out with caution.
For violations of liver function
Therapy in the presence of impaired hepatic function should be carried out with caution.
Drug interactions
Possible interactions:
- inhibitors of microsomal oxidation (cimetidine): reducing the likelihood of hepatotoxic effects;
- hepatotoxic drugs, ethanol, as well as phenytoin, barbiturates, flumecinol, phenylbutazone, rifampicin, tricyclic antidepressants and other inducers of microsomal oxidation in the liver: an increase in the production of hydroxylated active metabolites, which, even with a small overdose, can cause the development of severe intoxication;
- chloramphenicol: increasing its toxic effects;
- salicylates: increased risk of nephrotoxic effects;
- anticoagulants of indirect action: enhancing their action;
- drugs with uricosuric action: decrease in their effectiveness.
Analogs
Analogs of Tsefekon D are: Children's Panadol, Ksumapar, Calpol, Paracetamol, Daleron, Apap, Ifimol, Efferalgan, Strimol, Panadol, Perfalgan.
Terms and conditions of storage
Store in a place protected from moisture at temperatures up to 20 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Tsefekon D
According to reviews, Cefekon D is a safe, affordable and effective drug used to relieve pain and lower fever. The convenience of this dosage form for children is noted, especially for those who do not want or cannot take drugs orally. The development of adverse reactions, mainly allergic, is rarely indicated.
Price for Tsefekon D in pharmacies
The approximate price for Cefekon D of 50, 100 or 250 mg (10 pcs. In a package) is 31–49, 38–59 or 39–67 rubles, respectively.
Cefekon D: prices in online pharmacies
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Drug name Price Pharmacy |
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Cefekon D 50 mg rectal suppositories for children 10 pcs. RUB 29 Buy |
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Cefekon D rectal suppositories. 50mg 10 pcs. 42 RUB Buy |
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Cefekon D 100 mg rectal suppositories for children 10 pcs. RUB 44 Buy |
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Cefekon D 250 mg rectal suppositories for children 10 pcs. RUB 47 Buy |
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Cefekon D rectal suppositories. 100mg 10 pcs. RUB 51 Buy |
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Cefekon D rectal suppositories. 250mg 10 pcs. RUB 58 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
