Proviron
Proviron: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Proviron
ATX code: G03BB01
Active ingredient: mesterolone (mesterolone)
Manufacturer: Bayer Weimar GmbH & Co. KG (Bayer Weimar GmbH und Co. KG) (Germany)
Description and photo update: 2019-20-08
Proviron is an androgenic agent that compensates for the lack of production of androgens (male sex hormones), has a stimulating effect on the development of male secondary sexual characteristics and genitals, improves potency and libido, exhibits anabolic properties, stimulates erythropoiesis.
Release form and composition
Dosage form - tablets (20 pcs. In bottles, 1 bottle per package).
The active substance is mesterolone, its content in 1 tablet is 25 mg.
Pharmacological properties
Pharmacodynamics
The active component of Proviron, mesterolone, compensates for the lack of endogenous androgens due to a decrease in their production with age or for other reasons.
Taking the recommended therapeutic doses of the drug has the following effect on the male body:
- eliminates or softens the weakened working capacity, irritability, fatigue, weakening of memory and concentration of attention, impaired libido, depressive conditions, sleep disorders, psycho-vegetative disorders, caused by a deficiency of male sex hormones;
- eliminates potency disorders caused by androgen deficiency; if erectile dysfunction is caused by other reasons, Proviron is recommended to be used as an additional drug as part of complex therapy;
- stimulates the growth, development and function of organs dependent on male sex hormones; with a lack of androgens before the end of puberty, mesterolone promotes the development of external (secondary) sexual characteristics in patients; after reaching the age of puberty, Proviron helps to eliminate the loss of endocrine function;
- promotes an increase / normalization of the quantitative and qualitative composition of the ejaculate in infertility caused by oligozoospermia and insufficiency of interstitial Leydig cells; provides an increase in the level of fructose in the cytoplasm of sperm cells, increasing the likelihood of fertilization.
Pharmacokinetics
- absorption: as a result of oral administration of doses in the range of 25-100 mg, meterolone is absorbed quickly and almost completely; its absolute bioavailability is ~ 3%; the maximum level (C max) in the blood serum after 1.6 ± 0.6 hours is 3.1 ± 1.1 ng / ml, after which the serum concentration of the drug decreases;
- distribution: up to 98% of the substance binds to serum proteins, of which up to 40% with albumin, up to 58% with sex steroid binding globulin (SHBG);
- metabolism: meterolone is rapidly metabolized, serum clearance is 4.4 ± 1.6 ml × min -1 × kg -1; the main metabolite is 1α-methyl-androsterone, the other metabolite (making up about 3% of metabolites excreted by the kidneys) is 1α-methyl-5α-androstane-3α, 17β-diol. There was no metabolic conversion of mesterolone to estrogens or corticosteroids;
- excretion: Mesterolone is practically not excreted in an unchanged state. Up to 80% of its dose in the form of metabolites is excreted by the kidneys (55–70% in the conjugated form of 1α-methyl-androsterone) and about 13% with feces; in one week, up to 93% of the taken drug is excreted, while half of the indicated dose is excreted by the kidneys during the day. T 1/2 (terminal half-life) is 12-13 hours.
With daily intake of Proviron, its serum concentration increases by 30%.
Indications for use
According to the instructions, Proviron is prescribed for men in the following cases:
- Psychovegetative disorders and decreased performance in middle and old age, due to a lack of androgens (including irritability, rapid fatigue, weakening of memory and ability to concentrate, depressive moods, sleep disorders);
- Hypogonadism (decreased function of the gonads);
- Violations of potency and libido;
- Aplastic anemia;
- Infertility due to oligospermia and Leydig cell deficiency;
- Loss of function, such as the sex gland after reaching puberty.
Contraindications
Absolute:
- Liver tumors, including a history of
- Prostate cancer;
- Individual intolerance to the drug.
The androgenic agent is not intended for women.
Instructions for the use of Proviron: method and dosage
Proviron should be taken orally: swallow the tablets whole and wash down with liquid.
Unless the doctor has prescribed a different treatment regimen, the drug is usually used in the following doses:
- Reduced functional ability and potency disorders: initial dose - 1 tablet 3 times a day, then 1 tablet 1-2 times a day, the duration of treatment is determined individually, but the drug should be taken continuously for several months;
- Underdevelopment of the gonads: 1-2 tablets 3 times a day for several months, then it is possible to reduce the dose to a maintenance one - 1 tablet 2-3 times a day;
- Infertility (to improve the quality and quantity of sperm): 1 tablet 2-3 times a day during the spermatogenesis cycle (approximately 90 days). If necessary, after a break of several weeks, repeat the course of treatment;
- Lack of interstitial Leydig cells after reaching the age of puberty (to increase the concentration of fructose in the ejaculate): 1 tablet 2 times a day.
Side effects
In some patients, frequent and prolonged erections are possible. This side effect disappears after dose reduction or drug withdrawal.
In very rare cases, benign, and even less often, malignant changes in the liver occur, which lead to life-threatening bleeding in the abdominal cavity.
Overdose
Proviron is classified as a non-toxic drug. One-time cases of its reception in doses many times higher than therapeutic, are not capable of causing the development of undesirable reactions. However, long-term therapy with higher doses of mesterolone enhances its effectiveness and may have undesirable consequences.
special instructions
Proviron should not be taken by healthy men for the purpose of improving overall physical performance and muscle strengthening.
In connection with the risk of developing formations in the liver, it is recommended to consult a doctor in case of complaints in the epigastric region.
Influence on the ability to drive vehicles and complex mechanisms
There are no reports of a negative effect of the use of the drug on the ability to drive motor vehicles and other potentially dangerous mechanisms.
Application during pregnancy and lactation
Proviron is not intended for use in women.
Pediatric use
It is contraindicated to use a ganglion blocker for children and adolescents under 18 years of age.
For violations of liver function
Proviron is contraindicated in patients with liver tumors, including a history of data.
Drug interactions
There is no information on the interaction of Proviron with other medicinal substances / agents.
Analogs
Proviron analogs are: Mesterolone, Proviron-ver, Tamoxifen.
Terms and conditions of storage
Store in a cool, dry place out of reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Proviron
Reviews about Proviron are mainly left by bodybuilders, who usually take pills to suppress female sex hormones - estrogens, which cause breast enlargement in athletes (gynecomastia). It is noted that in this capacity the drug is more effective than its analogues.
Experts warn against the uncontrolled use of the drug, which can cause a gross hormonal imbalance.
Price for Proviron in pharmacies
Estimated price of Proviron (25 mg tablets) for 20 pcs. in the package is 665 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
