Pencrofton
Pencrofton: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Pencroftonum
ATX code: G03XB01
Active ingredient: mifepristone (mifepristone)
Producer: Pharmsintez JSC, Biochemist (Russia)
Description and photo updated: 2018-26-11
Pencrofton is an antiprogesterone drug that increases the tone of the myometrium and its contractile activity.
Release form and composition
Pencrofton is available in the form of tablets: light yellow with a green tinge, flat-cylindrical, with a dividing line (3 pcs.: In blister packs, in a cardboard box 1 pack; in polymer or glass jars of dark color, in a cardboard box 1 can) …
1 tablet contains:
- active substance: mifepristone - 200 mg;
- auxiliary components: milk sugar (lactose), calcium stearate 1-water, microcrystalline cellulose, corn starch, colloidal silicon dioxide (Aerosil A-300).
Pharmacological properties
Pharmacodynamics
Pencrofton is a synthetic steroidal antigestagenic drug. The mechanism of action of the active substance, mifepristone, is due to the blocking of progesterone activity at the receptor level, which causes desquamation of the decidua. As a result, there is an expulsion of the ovum.
The drug increases the contractility and sensitivity of the myometrium to prostaglandins. Does not possess gestagenic activity.
Pharmacokinetics
The maximum concentration after a single oral administration of mifepristone at a dose of 600 mg is reached after 1.5 hours and is 1.98 mg / l. Absolute bioavailability - 69%.
Plasma protein binding (albumin and acid alpha-1-glycoprotein) - 98%.
The half-life is 18 hours.
The distribution phase lasts up to 12 hours, then between 12–72 hours after administration, a slow elimination of mifepristone occurs, during this period its concentration decreases by 2 times. Further, a faster elimination of the drug occurs.
Indications for use
According to the instructions, Pencrofton is indicated for medical interruption of uterine pregnancy in the period up to 42 days of amenorrhea.
In addition, the drug is used in preparation for childbirth and for induction of labor during full-term pregnancy.
Contraindications
- acute or chronic form of renal and / or hepatic failure;
- hemostatic disorders, including previous anticoagulant therapy;
- adrenal insufficiency;
- long-term use of glucocorticosteroids;
- porphyria;
- anemia;
- uterine fibroids;
- inflammatory diseases of the genital organs;
- the presence of a scar on the uterus;
- severe extragenital pathology;
- smoking over the age of 35 - without consulting a therapist;
- individual intolerance to the components of the drug.
Additional contraindications when using the drug for abortion:
- the gestation period exceeds 42 days of amenorrhea;
- the presence of suspicions of an ectopic pregnancy;
- lack of clinical studies confirming pregnancy;
- conception occurred after the withdrawal of hormonal contraception or with the use of intrauterine contraception.
Additional contraindications for the use of mifepristone in preparation for childbirth or for induction of labor:
- premature or post-term pregnancy;
- abnormal position of the fetus;
- severe gestosis;
- preeclampsia, eclampsia;
- placenta previa;
- discrepancy between the size of the woman's pelvis and the fetal head;
- spotting from the vagina of unknown etiology.
With caution, Pencrofton should be prescribed for severe arterial hypertension, heart failure, heart rhythm disturbances, chronic obstructive pulmonary diseases (including bronchial asthma).
Instructions for the use of Pencrofton: method and dosage
Pencrofton tablets are taken orally.
The use of the drug is carried out in the presence of a doctor in specialized medical institutions equipped with the necessary resuscitation equipment. After taking Pencrofton, the woman's condition should be carefully monitored.
Recommended dosage:
- early medical termination of pregnancy: 3 tablets (600 mg) once. During the first two hours, the patient must be provided with medical supervision. After 1.5–2 days, an ultrasound examination (ultrasound) is shown. In order to confirm the termination of pregnancy, a clinical examination is carried out after 8-14 days, which includes an ultrasound scan and determination of the level of beta-chorionic hormone. If, on the 14th day after taking the drug, an ongoing pregnancy or an incomplete abortion is diagnosed, vacuum aspiration is performed and subsequent histological examination of the aspirate;
- preparation and induction of labor in full-term pregnancy: 1 tablet 1 time per day for two days. After 2-3 days, an assessment of the condition of the birth canal should be carried out. If necessary, the appointment of prostaglandins or oxytocin is possible.
Side effects
- postpartum complication: subinvolution of the uterus, lochiometer, metrorrhagia, discomfort and pain in the lower abdomen;
- from the urinary and reproductive systems: violation of the menstrual cycle, exacerbation of inflammatory diseases of the uterus, appendages and / or urinary tract, amenorrhea;
- others: weakness, nausea, vomiting, hyperthermia, diarrhea, chills, headache, dizziness, urticaria.
Overdose
Symptoms: Taking more than 10 tablets (2 g of mifepristone) may cause symptoms of adrenal insufficiency.
The appointment of symptomatic therapy is recommended.
special instructions
The use of Pencrofton should be carried out in compliance with all abortion-related requirements, including examination to prevent Rh alloimmunization.
The patient should be informed that if there is no effect from the use of the drug for medical abortion within 10-14 days, the ongoing pregnancy must be terminated in another way, since there is a high probability of fetal malformations.
In women with infective endocarditis or an artificial heart valve, mifepristone should be given in combination with antibiotics for prophylaxis.
You can not use the drug as a permanent contraception.
Pencrofton has no protective effect against sexually transmitted diseases and AIDS (acquired immunodeficiency syndrome).
Influence on the ability to drive vehicles and complex mechanisms
Reception of Pencrofton does not affect the speed of psychomotor reactions and the ability to concentrate.
Application during pregnancy and lactation
After taking the drug during lactation, breastfeeding should be stopped for 14 days.
With impaired renal function
The use of Pencrofton is contraindicated in acute or chronic renal failure.
For violations of liver function
It is contraindicated to take Pencrofton tablets for women with acute or chronic hepatic insufficiency.
Drug interactions
Avoid the appointment of Pencrofton while using acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (NSAIDs).
After taking the drug, you can start NSAID treatment only after 8-12 days.
Analogs
Pencrofton's analogs are Agesta, Ginepristone, Ginestril, Zhenale, Miropriston, Mifepristone, Mifolian, Mifegin, Mifeprex.
Terms and conditions of storage
Keep out of the reach of children.
Store at a temperature of 18-22 ° C, protected from moisture and light.
Shelf life is 2 years.
Terms of dispensing from pharmacies
The drug is not dispensed through the pharmacy chain. It is possible to purchase pills directly for the procedure only in medical obstetric and gynecological institutions belonging to the state health care system, municipal and private institutions licensed for this type of activity.
Reviews about Pencrofton
Reviews about Pencrofton regarding its effectiveness when used to terminate an unwanted pregnancy, the patient leaves mostly positive. At the same time, they especially emphasize that one cannot resort to using the drug at home, using sources from the Internet for consultation. Medical termination of pregnancy, like any other abortion, is fraught with the development of severe bleeding and other serious consequences.
Price for Pencrofton in pharmacies
The price of Pencrofton in pharmacies is unknown, since the drug is supplied only to specialized medical institutions.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
