Tafen Nazal
Tafen Nazal: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tafen nasal
ATX code: R01AD05
Active ingredient: budesonide (budesonide)
Manufacturer: LEK d.d. (LEK dd) (Slovenia)
Description and photo update: 2019-20-08
Prices in pharmacies: from 275 rubles.
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Tafen Nasal is a glucocorticosteroid (GCS) drug for intranasal use.
Release form and composition
The dosage form of the drug is a dosed nasal spray: a homogeneous suspension of white or almost white color (200 doses in dark glass vials, complete with a dispenser, a tip and a nosepiece; in a cardboard box 1 set).
Composition of 1 dose of the drug:
- active substance: budesonide - 50 mcg;
- auxiliary components: propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium carboxymethyl cellulose / microcrystalline cellulose, polysorbate 80, simethicone emulsion, sucrose, EDTA disodium salt, hydrochloric acid, propylene glycol, purified water.
Pharmacological properties
Pharmacodynamics
The active component of Tafen Nasal is budesonide, a glucocorticosteroid for intranasal use, which has a pronounced anti-inflammatory and antiallergic effect. Does not possess mineralocorticoid activity. When used in therapeutic doses, it has almost no resorptive effect. Well tolerated with long-term treatment.
Budesonide inhibits the release of inflammatory mediators, increases the synthesis of anti-inflammatory proteins, and reduces the number of eosinophilic granulocytes and mast cells. Reduces the release of lymphokines from lymphocytes, free radicals from macrophages and toxic proteins from eosinophils. Also, budesonide reduces the binding of adhesive molecules to endothelial cells, thereby reducing the flow of leukocytes to the site of allergic inflammation. Increases the number of beta-adrenergic receptors of smooth muscles. It inhibits the activity of phospholipase 2A, as a result of which the synthesis of surfactants (surfactants), leukotrienes and prostaglandins, which are mediators that induce an inflammatory reaction, is inhibited.
Budesonide also inhibits the synthesis of histamine, as a result of which its level in mast cells decreases.
Tafen Nasal suppresses the late and early phases of an allergic reaction, reduces the severity of symptoms in allergic rhinitis, and reduces inflammation in the upper respiratory tract. The therapeutic effect appears after 2-3 days of using the drug.
Pharmacokinetics
After inhalation of budesonide at the maximum recommended daily dose (400 μg), the maximum plasma concentration is 1 nmol / L and is reached within 0.7 hours. Approximately 20% of the dose enters the systemic circulation.
Budesonide is characterized by good tissue distribution and binding to plasma proteins. The volume of distribution is 301 liters.
The systemic bioavailability of the drug is low, since more than 90% of absorbed budesonide is inactivated during the one-step metabolism in the liver. The glucocorticoid activity of metabolites does not exceed 1%.
The half-life is 2-3 hours. The metabolites are excreted mainly in the urine (90%) and feces.
Indications for use
Spray Tafen Nasal is recommended for the treatment and prevention of year-round and seasonal allergic rhinitis, non-allergic rhinitis and nasal polyposis.
Contraindications
- mycoses, viral and bacterial infections of the respiratory tract;
- pulmonary tuberculosis in active form;
- children under 6 years old;
- individual hypersensitivity to budesonide or other components of the drug.
Instructions for the use of Tafena Nazal: method and dosage
Spray Tafen Nasal is intended for injection into the nasal passages.
Recommended dosage regimen for children over 6 years of age and adult patients:
- the initial period of treatment: in each nostril, 2 doses (100 mcg of budesonide) 2 times a day;
- standard maintenance therapy: in each nostril 1 dose 2 times a day or 2 doses 1 time a day, in the morning (maintenance dose is the lowest effective dose that relieves rhinitis symptoms).
The maximum single dose is 200 mcg (100 mcg in each nostril), the maximum daily dose is 400 mcg, the duration of use is no more than three months.
For a full therapeutic effect, it is necessary to apply the spray regularly and correctly.
If the next dose is missed, it should be taken as soon as possible, but no later than an hour before the next regular dose.
Side effects
Side effects that develop when using Tafen Nasal spray (usually extremely rare and transient):
- respiratory system: cough, irritation of the mucous membrane of the nasal passage and throat, nosebleeds; less often there is dryness of the nasal mucosa, sneezing;
- dermatological responses: urticaria, rash, dermatitis;
- others: dizziness, increased fatigue.
In isolated cases, due to the use of nasal corticosteroids, the following were noted: angioedema, perforation of the nasal septum, loss of smell, growth retardation, tachycardia.
Overdose
In case of an accidental overdose of Tafen Nasal, no obvious symptoms were recorded. Acute overdose is unlikely.
Long-term use of high doses, as well as the simultaneous administration of other corticosteroids, can cause signs of hypercortisolism. In this case, you should stop using the drug, reducing the dose gradually.
special instructions
When switching from therapy with systemic corticosteroids to a nasal spray (due to the risk of developing adrenal insufficiency), increased attention to patients is required during the period of restoration of the function of the hypothalamic-pituitary-adrenal system (HPA).
GCS slow down wound healing, therefore, when prescribing Tafen Nasal spray, patients who have recently undergone a nose injury / operation should be careful.
In the treatment of allergic rhinitis, the drug must be taken regularly for the full therapeutic effect.
Avoid getting the spray in the eyes.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Tafen Nazal does not affect the concentration of attention and the speed of psychomotor reactions necessary for driving vehicles and controlling complex mechanisms.
Application during pregnancy and lactation
Tafen Nasal can be used during pregnancy only as directed by a doctor, who will assess the degree of the ratio of the expected benefits and potential risks.
If treatment is necessary during lactation, it is recommended to stop breastfeeding.
Pediatric use
Tafen Nazal is allowed to be used to treat children over 6 years old.
Drug interactions
- phenytoin, phenobarbital, rifampicin (inducers of microsomal oxidation): the effectiveness of the drug may decrease;
- methandrostenolone, ketoconazole, estrogens: enhance the effect of budesonide.
Analogs
The analogues of Tafen Nazal are Pulmicort Turbuhaler, Benacort, Benacap, Budenofalk, Budenit Steri-Neb, Budesonide Easyheiler, Kortiment, Budoster, etc.
Terms and conditions of storage
Store out of the reach of children at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tafen Nazal
According to reviews, Tafen Nazal is an effective treatment for rhinitis. The spray has a mild effect, eliminates nasal congestion well, does not dry out and does not irritate the mucous membrane, does not cause addiction. The drug helped many patients to overcome addiction to vasoconstrictor drops, as well as get rid of chronic rhinitis.
The disadvantages include a short-term burning sensation in the nose after instillation, as well as the relatively high cost of the drug, but most patients consider it justified.
Price for Tafen Nazal in pharmacies
The approximate price for Tafen Nazal for 1 bottle of 10 ml is 335–395 rubles.
Tafen Nazal: prices in online pharmacies
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Drug name Price Pharmacy |
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Tafen nasal 50 mcg / dose 200 doses nasal spray dosed 10 ml 1 pc. 275 RUB Buy |
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Tafen nasal spray nasal. dosage. 50mcg / dose 200 doses 10ml 292 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
