Tazepam
Tazepam: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Tazepam
ATX code: N05BA04
Active ingredient: oxazepam (oxazepam)
Manufacturer: Tarkhominsk pharmaceutical plant "Polfa", A. O. (Tarchomin Pharmaceutical Works "Polfa", SA) (Poland)
Description and photo update: 2019-26-08
Tazepam is a drug that has a hypnotic, muscle relaxant, anticonvulsant and anxiolytic effect.
Release form and composition
The dosage form of Tazepam is film-coated tablets (25 pieces in blisters, in a cardboard box 2 blisters).
Composition of 1 tablet:
- active substance: oxazepam - 10 mg;
- auxiliary components: potato starch - 5.5 mg; magnesium stearate - 1 mg; gelatin - 2.4 mg; polysorbate 80 - 0.1 mg; lactose monohydrate - 53.8 mg; sodium carboxymethyl starch (type A) - 0.5 mg; talc - 1.7 mg;
- shell: macrogol 6000 - 0.03 mg; hypromellose - 0.17 mg.
Pharmacological properties
Pharmacodynamics
Oxazepam is a psychotropic substance and belongs to the category of 1,4-benzodiazepine derivatives. Tazepam acts on many structures of the central nervous system (CNS), mainly on the hypothalamus and limbic system, which are responsible for the regulation of emotional activity. Similar to other benzodiazepines, oxazepam activates the inhibitory effect of GABAergic neurons localized in the hypothalamus, thalamus, cerebral cortex, cerebellum and hippocampus. In the course of research, benzodiazepine-specific binding sites were found, which are protein structures of the cell membrane that are associated with a complex that includes a chlorine channel and a GABA-A receptor.
The mechanism of action of oxazepam is explained by the modulation of the sensitivity of the GABAergic receptor, which causes an increase in the affinity of the receptor for gamma-aminobutyric acid (GABA), which is an inhibitory endogenous neurotransmitter. Activation of the GABA-A or benzodiazepine receptor leads to the activation of the transport of chlorine ions along the chlorine channel into the neuron, which results in hyperpolarization of the cell membrane and, as a result, suppression of neuronal activity.
Tazepam has a hypnotic effect and has a slight relaxing effect on skeletal muscles.
Pharmacokinetics
After oral administration, oxazepam is absorbed from the gastrointestinal tract (GIT) slowly but completely. Its degree of binding to blood plasma proteins is 97%. After taking Tazepam at a dose of 30 mg, the maximum concentration of the active component in the blood plasma is 450 ng / ml and is reached in 1–4 hours. Oxazepam crosses the placental and blood-brain barriers, and is also determined in breast milk.
The drug is metabolized in the liver, forming glucuronides, which do not exhibit pharmacological activity.
The half-life varies from 5 to 15 hours. Oxazepam is excreted through the kidneys and intestines. The equilibrium concentration of a substance in the blood is determined 1-3 days after the start of the course of treatment. With repeated administration, oxazepam is accumulated in the body in minimal amounts, since it belongs to the group of benzodiazepines with a short and medium half-life. After the abolition of Tazepam, the active substance is excreted from the body quickly enough.
Indications for use
- falling asleep disorders;
- tension and excitement, developed against the background of abstinence and chronic alcoholism;
- state of anxiety (in old age);
- anxiety on the background of neurasthenic / depressive syndromes.
Contraindications
Absolute:
- dizziness;
- myasthenia gravis;
- breathing disorder of central origin;
- glaucoma;
- balance disorders;
- I trimester of pregnancy and lactation;
- individual intolerance to the components of the drug.
Relative (Tazepam is prescribed with caution under medical supervision in the presence of such diseases / conditions as):
- the likelihood of developing drug addiction;
- II – III trimesters of pregnancy (therapy can be carried out only if there are strict indications).
Instructions for the use of Tazepam: method and dosage
Tazepam tablets are taken orally with plenty of liquid.
Recommended dosage regimen:
- withdrawal symptoms and anxiety: 15-30 mg per day, divided into 3-4 doses; if necessary, in a hospital setting, the daily dose can be increased to 120 mg;
- insomnia: 10-30 mg per day; the preferred time to take the drug is 1 hour before bedtime.
The daily dose of Tazepam for elderly patients (from 65 years) is up to 40 mg.
Side effects
Possible side reactions: fatigue, memory impairment, weakness, drowsiness, decreased ability to concentrate, impaired assessment of space / orientation, allergic skin manifestations, digestive system disorders (in the form of diarrhea, nausea, abdominal discomfort), paradoxical reactions (in the form of insomnia, psychomotor agitation, muscle tremor, aggressiveness, seizures).
Overdose
An overdose of Tazepam can lead to the development of symptoms such as slurred speech, disorientation, drowsiness, loss of consciousness, coma. The greatest danger to the patient's life is intoxication associated with the joint intake of oxazepam and alcoholic beverages or other drugs that inhibit the activity of the central nervous system.
In case of an overdose, it is necessary to carry out procedures aimed at removing oxazepam from the body and / or reducing its absorption in the gastrointestinal tract (gastric lavage, intake of activated carbon). It is also recommended to constantly monitor vital functions (pressure, pulse, respiratory activity), and if necessary, symptomatic therapy is prescribed.
Flumazenil is a specific antidote for oxazepam. In case of deliberate overdose, it should be remembered that the patient may have taken several different medicines at the same time.
special instructions
Continuous therapy with Tazepam for several months can lead to addiction and psychophysical dependence.
For pediatric and elderly patients (under 18 and over 65 years of age), Tazepam can be taken only as directed by a doctor and in reduced doses.
It is necessary to cancel treatment gradually.
Drinking alcohol while taking Tazepam is not recommended.
Influence on the ability to drive vehicles and complex mechanisms
During the course of treatment with Tazepam, it is necessary to stop driving vehicles and engage in potentially hazardous activities that require increased concentration, as well as drinking alcohol.
Application during pregnancy and lactation
Oxazepam has a toxic effect on the fetus and increases the risk of developing congenital defects when taken in the first trimester of pregnancy. Taking the drug in therapeutic doses at later stages of pregnancy can lead to depression of the central nervous system of the newborn. In children, especially young children, there is an increased sensitivity to the action of benzodiazepines, which suppress the activity of the central nervous system. The use of Tazepam immediately before the onset of labor or during childbirth can provoke hypothermia, depression of the respiratory center, hypotension, decreased muscle tone and sluggish sucking syndrome of the newborn in a newborn.
Breastfeeding your baby is a contraindication to taking oxazepam.
Pediatric use
According to the instructions, it is unacceptable to prescribe Tazepam to children under 6 years of age.
With impaired renal function
Patients with renal insufficiency Tazepam is used with caution.
For violations of liver function
Patients with hepatic impairment Tazepam is used with caution.
Use in the elderly
The drug is prescribed with caution to elderly patients.
Drug interactions
Combined use with drugs with neuroleptic, antiepileptic, hypnotic, antihistamine, analgesic and narcotic effects can lead to an increase in the effect of Tazepam.
Analogs
Tazepam analogues are: Nozepam, Grandaksin, Fenazepam IC, Diazepam, Sibazon, Fazepam-Zn, Elenium, Relanium, Afobazol, Zolomax, etc.
Terms and conditions of storage
Store in a dark place at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tazepam
Almost all reviews about Tazepam are favorable and emphasize its qualitative advantage over analogues: it has a milder effect and practically does not cause serious adverse reactions. However, experts report that taking this drug often leads to the development of addiction.
Price for Tazepam in pharmacies
At the moment, the price of Tazepam remains unknown, since the drug is not available for sale.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
