Sulfalen
Sulfalen: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Sulfalen
ATX code: J01ED02
Active ingredient: sulfalene (Sulfalene)
Producer: Obolenskoe - pharmaceutical company, CJSC (Russia)
Description and photo update: 2019-26-08
Sulfalene is a drug that has antibacterial, bacteriostatic and antimicrobial effects.
Release form and composition
Sulfalena dosage form - tablets: color - white or white with a yellowish tinge, shape - flat-cylindrical (10 pcs. In blister and non-cell contour packages, 1–5 packages in a cardboard box).
Composition of 1 tablet:
- active substance: sulfalene - 200 mg;
- additional components: magnesium stearate, potato starch, polyvinylpyrrolidone.
Pharmacological properties
Pharmacodynamics
Sulfalene has a bacteriostatic effect, has antimicrobial activity.
The main effect of the substance is to block the utilization of para-aminobenzoic acid by microorganisms and the synthesis of folate, due to which the reproduction of gram-positive / gram-negative microorganisms (including anaerobes, streptococci, pneumococci, staphylococci) is inhibited.
Sulfalene has no effect on bacterial strains showing resistance to sulfonamides.
Pharmacokinetics
After oral administration, sulfalene is rapidly absorbed from the gastrointestinal tract.
C max (maximum concentration) in the blood is reached in 4-6 hours. The substance binds to plasma proteins to a lesser extent than other ultra-long-term and long-acting sulfonamides. This provides a high concentration of free active sulfalene in the blood.
It penetrates well into tissues and body fluids. It is found in bile in high concentrations. It circulates in the blood for a long time. The half-life is on average 65 hours. 60% of the dose is eliminated in 9 days. Slow excretion is associated with intense reabsorption in the renal tubules. It is excreted mainly in the urine as metabolites.
Indications for use
According to the instructions, Sulfalen is prescribed for the treatment of infections that are sensitive to the action of the active substance:
- pneumonia, bronchitis (respiratory organs);
- cystitis, pyelitis, urethritis, etc. (urinary tract);
- cholangitis, cholecystitis (biliary tract);
- otitis media, osteomyelitis, wound infection, mastitis, abscesses, sinusitis (purulent infections of various localization).
Contraindications
Absolute:
- drug fever;
- dermatitis in severe course;
- hemolytic anemia;
- agranulocytosis;
- chronic renal failure with azotemia;
- hepatitis;
- deficiency of glucose-6-phosphate dehydrogenase;
- pregnancy and lactation;
- hypersensitivity to drug components.
Relative (when prescribing Sulfalena, caution is required, therapy should be carried out under the supervision of blood and urine tests):
- diseases of the hematopoietic system;
- decompensation of cardiac activity;
- functional disorders of the kidneys;
- liver disease.
Instructions for the use of Sulfalena: method and dosage
Sulfalene tablets are taken orally, preferably 30 minutes before meals.
Dosing regimen for adults:
- fast infections in acute course: daily, daily dose on the first day - 1000 mg, then - 200 mg;
- chronic, long-term current infections: 1 time in 7-10 days, daily dose - 2000 mg, course 1-1.5 months.
Side effects
Possible disorders: agranulocytosis, leukopenia, headache, allergic reactions, dyspepsia, crystalluria, drug fever.
Overdose
The main symptoms of an overdose: vomiting, nausea, allergic reactions, agranulocytosis, crystalluria.
special instructions
To prevent the loss of crystals in the kidneys, patients are advised to drink plenty of fluids.
In the presence of impaired renal excretory function, Sulfalen is taken under the control of blood and urine tests.
Application during pregnancy and lactation
Sulfalene is not prescribed during pregnancy / lactation.
With impaired renal function
- chronic renal failure with azotemia: therapy is contraindicated;
- impaired renal function: Sulfalene should be used under medical supervision (under the supervision of urine / blood tests).
For violations of liver function
In the presence of liver disease, therapy is carried out with caution (under the supervision of urine / blood tests).
Drug interactions
With the combined use of Sulfalena with certain drugs / substances, the following effects may develop:
- methotrexate and other folic acid antagonists: the likelihood of folic acid deficiency increases;
- phenytoin (in the treatment of epilepsy): the likelihood of toxic reactions increases;
- diaminopyrimidine derivatives (tetroxoprim, trimethoprim, pyrimethamine): the effectiveness of sulfalene is enhanced;
- methoxalen (in the treatment of psoriasis): the likelihood of photosensitization increases;
- hexamethylenetetramine or drugs that increase the formation of uric acid (ammonium chloride): the likelihood of insoluble compounds in the renal pelvis in the form of calculi increases.
Analogs
The analogues of Sulfalene are: Sulfalene-HC, Sulfadimethoxin, Kelfizin, Sulfalene-meglumine, Sulfapyridazine, Sulfadimethoxin, etc.
Terms and conditions of storage
Store in a dry place at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Sulfalene
According to few reviews, Sulfalene is an effective drug. But before using it, it is necessary to pass an analysis for the sensitivity of the pathogen to the action of the drug. They also indicate that during the period of therapy, an abundant drink is recommended.
Price for Sulfalene in pharmacies
The price of Sulfalene is unknown, since the drug is not available in pharmacies.
The approximate cost of the analogue: Sulfadimethoxin (10 tablets of 500 mg) - 34–41 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
