Subetta
Subetta: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Subetta
ATX code: A10BX
Active ingredient: antibodies to the C-terminal fragment of the beta subunit of the insulin receptor + antibodies to endothelial NO synthase
Producer: NPF Materia Medica Holding, LLC (Russia)
Description and photo update: 2018-27-07
Prices in pharmacies: from 150 rubles.
Buy
Subetta is a hypoglycemic drug.
Release form and composition
The drug is available in the form of tablets for sucking: flat-cylindrical, from almost white to white, with a line and a chamfer, on the side with a dividing line there is the inscription MATERIA MEDICA, on the other side - SUBETTA (20 pcs. In blisters, in a cardboard box 1, 2 or 5 packs and instructions for using Subetta).
1 tablet contains:
- active ingredients: antibodies to the C-terminal fragment of the beta subunit of the insulin receptor affinity purified - 0.006 g, antibodies to endothelial NO (nitric oxide) synthase affinity purified - 0.006 g (a mixture of three active aqueous-alcoholic dilutions of each substance, diluted, respectively, is applied to isomalt 100 12, 100 30, 100 200 times);
- auxiliary components: isomalt, magnesium stearate, crospovidone.
Pharmacological properties
Pharmacodynamics
Subetta is a complex hypoglycemic drug intended for inclusion in the complex therapy of patients with diabetes mellitus if they have insulin resistance. The mechanism of action of the drug is due to the effect of a synergistic effect on the sensitivity of somatic cells to insulin, which occurs due to nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor. This increases the effectiveness of insulin therapy, allows you to stabilize the doses used, and reduce the likelihood of side effects.
Through the mechanisms of allosteric modulation, antibodies to the C-terminal fragment of the beta subunit sensitize the insulin receptor, which leads to an increase in its sensitivity to endogenous and administered insulin and activation of the metabolism of insulin-dependent glucose.
Antibodies to the beta subunit have a moderately pronounced hypoglycemic effect (when taken on an empty stomach, the level of glycemia decreases by 0.7-1.4 mmol / l). Their long-term use is not accompanied by the development of side effects in the form of hypoglycemia, acidosis, impaired hemostasis and hematopoiesis, increased body weight.
The effect of antibodies to endothelial NO synthase causes an increase in the activity of endothelial NO synthase and the content of NO, which has an endothelioprotective effect. There is a decrease in vascular reactivity, a decrease in vascular spasm, the level of blood pressure normalizes, and peripheral microcirculation improves. In addition, antibodies to endothelial NO synthase have a moderately pronounced psychotropic effect, which is manifested by such effects as anti-anxiety, antiasthenic, vegetative stabilizing.
While taking the drug, the severity of complications of diabetes mellitus decreases: cardiovascular disorders, nephropathies, neuropathies.
Pharmacokinetics
Ultra-low doses of antibodies are technically impossible to detect in biological fluids, tissues and organs, therefore, the pharmacokinetics of the drug has not been studied.
Indications for use
The use of Subetta is indicated for patients with diabetes mellitus with insulin resistance as part of complex therapy.
Contraindications
The use of Subetta tablets is contraindicated in patients with individual hypersensitivity to the drug components.
Subetta, instructions for use: method and dosage
Subetta tablets are taken orally, without swallowing whole, but holding in the mouth until they are completely dissolved. The drug should not be taken during meals.
Recommended dosage: 1 pc. 2-4 times a day. The doctor sets the frequency of admission individually, taking into account the degree of diabetes compensation.
Side effects
Development of hypersensitivity reactions is possible.
Overdose
Symptoms: dyspeptic symptoms.
Treatment: the appointment of symptomatic therapy.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
Subetta does not affect the patient's ability to drive vehicles and complex mechanisms.
Drug interactions
There is no information about the incompatibility of the drug with other drugs.
Analogs
There is no information about Subetta's analogues.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C in a dark place.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Subetta
Reviews about Subetta are currently not available.
Price for Subetta in pharmacies
The price of Subetta for a pack containing 100 tablets can range from 260 rubles.
Subetta: prices in online pharmacies
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Drug name Price Pharmacy |
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Subetta lozenges 100 pcs. RUB 150 Buy |
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Subetta tablets for rasas. 100 pieces. RUB 300 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
