Sorbifer Durules
Sorbifer Durules: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Sorbifer Durules
ATX code: B03AA07
Active ingredient: Ascorbic acid + Ferrous sulfate
Manufacturer: OJSC Pharmaceutical Plant Egis, Vergria
Description and photo update: 19.10.2018
Prices in pharmacies: from 329 rubles.
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Sorbifer Durules is an iron preparation, a remedy with antianemic action.
Release form and composition
Dosage form Sorbifer Durules - coated tablets: round, convex on both sides, light yellow, engraved on one of the sides with the letter "Z", a gray core is visible on the fracture; have a characteristic odor (30 and 50 tablets in brown glass bottles, sealed with a polyethylene lid, with an accordion-shock absorber and control of the first opening; each bottle is packed in a cardboard box).
Composition of the preparation:
- active substance: ferrous sulfate, in 1 tablet - 320 mg, which corresponds to the content of 100 mg Fe 2+ and 60 mg of ascorbic acid;
- auxiliary components: polyethylene powder, macrogol 6000, hypromellose, carbomer 934 R, povidone K-25, magnesium stearate;
- shell composition: hard paraffin, yellow iron oxide, titanium dioxide.
Pharmacological properties
Pharmacodynamics
Sorbifer Durules is a drug that compensates for the lack of iron - an irreplaceable component that takes part in the oxidative processes of the body and is necessary for the formation of hemoglobin.
Thanks to a special production technology, the drug provides a gradual release of iron ions for a long time. The plastic matrix of the tablets is absolutely inert in the digestive juice, but completely disintegrates under the influence of intestinal peristalsis - this is how the active substance Sorbifer Durules is released.
Pharmacokinetics
Durules is a technology that provides a gradual release and an even supply of iron ions. When taking Sorbifer Durules at a dose of 100 mg 2 times a day, there is 30% more iron absorption compared to the use of conventional iron preparations.
Iron is characterized by high bioavailability and absorption. Absorbed mainly in the duodenum and proximal jejunum. Its connection with plasma proteins is at least 90%. It is deposited in the cells of the system of phagocytic macrophages and hepatocytes in the form of ferritin or hemosiderin, in the muscles - in the form of myoglobin.
The half-life of iron is approximately 6 hours.
Indications for use
According to the instructions, Sorbifer Durules is recommended to be taken with iron deficiency and iron deficiency anemia.
As a prophylactic agent, it can be prescribed to blood donors, pregnant and lactating women.
Contraindications
Absolute contraindications:
- conditions characterized by impaired utilization of iron (lead, sideroblastic or hemolytic anemia);
- conditions accompanied by an increased content of iron in the body (hemochromatosis, hemosiderosis);
- obstructive changes in the digestive tract and / or esophageal stenosis;
- children under 12 years old;
- hypersensitivity to any component of the drug.
Relative contraindications (diseases requiring caution in the use of iron preparations):
- inflammatory bowel diseases such as enteritis, ulcerative colitis, Crohn's disease, diverticulitis;
- peptic ulcer and 12 duodenal ulcer.
Instructions for the use of Sorbifer Durules: method and dosage
Coated tablets Sorbifer Durules should be taken orally without chewing, swallowing whole and drinking plenty of water (at least ½ cup).
Adults and adolescents from 12 years old are prescribed 1 tablet 1-2 times a day. With iron deficiency anemia, it is possible to increase the daily dose to 3-4 tablets in 2 divided doses (morning and evening) until the iron depot in the body is replenished (approximately 3-4 months).
For prophylactic purposes, pregnant and breastfeeding women are prescribed 1 tablet once a day, for medicinal purposes - 1 tablet 2 times a day with an interval of 12 hours.
The duration of treatment is determined by the moment the optimal hemoglobin level is reached. For further replenishment of the iron depot, taking Sorbifer Durules can be continued for another 2 months.
Side effects
The most common side effects are from the gastrointestinal tract: diarrhea or constipation, abdominal pain, nausea and vomiting. The frequency of adverse reactions increases with increasing dose from 100 to 400 mg.
In rare cases (<1/100), dizziness, headache, weakness, hyperthermia of the skin, allergic reactions (itching, rash), ulceration and stenosis of the esophagus are possible.
Overdose
Symptoms: pallor of the skin, fatigue or weakness, diarrhea mixed with blood, vomiting, cold clammy sweat, paresthesia, hyperthermia, acidosis, palpitations, decreased blood pressure, weak pulse.
In case of a severe overdose, muscle cramps, renal failure, liver damage, coagulopathy, hypoglycemia, signs of peripheral circulatory collapse, and coma may appear in 6–12 hours.
In case of taking the drug in a dose significantly higher than the recommended one, you must urgently consult a doctor. As a first aid, you should wash your stomach, drink milk or a raw egg (to bind iron ions in the gastrointestinal tract). As a therapeutic measure, deferoxamine (a complexing agent that binds free iron) is administered and symptomatic therapy is carried out.
special instructions
Like other iron preparations, Sorbifer Durules can stain feces in a dark color - this phenomenon is not a reason for stopping therapy, since it has no clinical significance.
Influence on the ability to drive vehicles and complex mechanisms
While taking Sorbifer Durules, there is a possibility of dizziness, and therefore you should be careful when driving and performing potentially hazardous activities.
Application during pregnancy and lactation
For pregnant and breastfeeding women, Sorbifer Durules tablets can be used according to indications.
Pediatric use
In pediatrics, iron is not used to treat children under 12 years of age.
Drug interactions
Antacids, the content of magnesium carbonate or aluminum hydroxide, reduce the absorption of iron, therefore, a minimum of 2-hour intervals should be observed between doses of the drugs.
Sorbifer Durules, with simultaneous use, can reduce the absorption of methyldopa, levodopa, enoxacin, levofloxacin, thyroid hormones, clodronate, penicillamine, grepafloxacin and tetracyclines. For this reason, 2-hour intervals should also be maintained between doses, with the exception of the combined use of drugs from the tetracyclines group - in this case, the break should be at least 3 hours.
During therapy with Sorbifer Durules, you should not take ofloxacin, doxycycline, ciprofloxacin and norfloxacin.
Analogs
The analogues of Sorbifer Durules are: Aktiferin, Feron forte, Ranferol-12, Globigen, Hemoferon, Feroplekt, Totema, Gemsinerad-TD.
Terms and conditions of storage
Store in compliance with the temperature regime 15-25 ° С out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Sorbifer Durules
According to reviews, Sorbifer Durules is an effective remedy that, if taken correctly, quickly enough helps to fill the lack of iron.
Pregnant women who took it to restore hemoglobin levels also speak well of the drug.
Patients note the good tolerance of Sorbifer Durules, the rare development of side effects.
Price for Sorbifer Durules in pharmacies
The price of Sorbifer Durules is 340–530 rubles for a pack of 30 tablets and 450–690 rubles for a pack of 50 tablets.
Sorbifer Durules: prices in online pharmacies
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Drug name Price Pharmacy |
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Sorbifer Durules 100 mg + 60 mg film-coated tablets 30 pcs. 329 r Buy |
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Sorbifer Durules tablets p.o. 30 pcs. 342 r Buy |
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Sorbifer Durules 100 mg + 60 mg film-coated tablets 50 pcs. 370 rbl. Buy |
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Sorbifer Durules tablets p.o. 50 pcs. 468 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
