Silibinin
Silibinin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Silibinin
ATX code: A05BA03
Active ingredient: milk thistle fruit extract (Silybi mariani fructuum extract)
Manufacturer: CJSC "Vifitech" (Russia)
Description and photo update: 2019-25-12
Prices in pharmacies: from 83 rubles.
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Silibinin is a hepatoprotective agent of plant origin.
Release form and composition
The drug is produced in the form of tablets: round, flat-cylindrical, beveled, from pale brown to brown interspersed (10 pieces in a blister strip; in a cardboard box 1 or 3 packages and instructions for use of Silibinin).
1 tablet contains:
- active substance: silybinin dry extract (milk thistle fruit extract) with the inclusion of the sum of flavolignans in terms of absolute dry matter and silybin 65% - 100 mg;
- additional components: magnesium stearate, potato starch, milk sugar (lactose).
Pharmacological properties
Silibinin is a herbal preparation characterized by hepatoprotective and antitoxic properties, the therapeutic effect of which is associated with an effect on the metabolism of hepatocytes. The flavolignans contained in the drug help stabilize lysosomal and cell membranes, prevent the release of enzymes from cells. The drug activates the production of enzymes and proteins in hepatocytes, blocks the penetration of toxins into liver cells, suppresses degenerative processes and enhances regenerative processes in the liver. Interacts with free radicals and inhibits lipid peroxidation.
Indications for use
Silibinin tablets are used for the following conditions / diseases:
- chronic hepatitis, toxic liver damage, liver cirrhosis (as part of a combination treatment);
- conditions after hepatitis;
- chronic intoxication, including professional (for prevention purposes).
The drug is also used for prophylaxis with prolonged intake of drugs and alcohol.
Contraindications
- age up to 12 years;
- hypersensitivity to the components of the hepatoprotective agent.
Silibinin, instructions for use: method and dosage
Silibinin tablets are taken orally.
For adults and children over 12 years of age, the following dosage regimen is recommended: 3 times a day, 30 minutes before meals, 1-2 tablets, course - 25-30 days.
If necessary, you can repeat the course of therapy after 1–3 months.
Side effects
Allergic reactions may develop during treatment with the drug. In some patients, a laxative effect may be observed.
Overdose
In case of an overdose, an increase in the severity of side effects is possible.
Treatment is symptomatic.
special instructions
There is no data.
Influence on the ability to drive vehicles and complex mechanisms
The effect of a hepatoprotective agent on the ability to drive a car and control complex mechanisms has not been studied.
Application during pregnancy and lactation
Pregnant and lactating women are not recommended to take the drug.
Pediatric use
Children under 12 years of age should not use the drug.
Drug interactions
The interaction of Silibinin with other drugs / substances has not been studied.
Analogs
Silibinin's analogues are: Silimar, Karsil, Legalon 140, Forliver Help, Legalon 70, Carsil Max, Carsil Forte, etc.
Terms and conditions of storage
Store in a place protected from moisture and light, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Silibinin
According to most reviews, Silibinin is an effective herbal preparation used to treat diseases of the hepatobiliary system. The use of the drug as part of complex therapy is effective in the treatment of toxic liver damage, chronic hepatitis, and cirrhosis of the liver. The drug is successfully used to protect the liver in case of chronic intoxication, drug and ethanol poisoning.
At the same time, some patients note that, against the background of serious violations of hepatic function, a tangible result from therapy was not achieved. The positive effect of the phytopreparation was observed only in diseases of mild severity and a slight increase in liver function tests. Moreover, the course of treatment was quite long (up to 3 months) and silibinin was taken in high doses. In any case, the attending physician should prescribe the drug, set the duration of treatment and the dosage. There are no complaints about the development of side effects.
The price of Silibinin in pharmacies
The price of Silibinin, tablets 100 mg, for 30 pcs. in the package can be 100-110 rubles.
Silibinin: prices in online pharmacies
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Drug name Price Pharmacy |
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Silibinin 100 mg tablets 30 pcs. 83 rbl. Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
