Rinzasip for children
Rinzasip for children: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Rinzasip for children
ATX code: N02BE51
Active ingredient: paracetamol (Paracetamol), ascorbic acid (Ascorbic acid), pheniramine (Pheniramine)
Manufacturer: Unique Pharmaceutical Laboratories (India)
Description and photo update: 12.12.2019
Prices in pharmacies: from 243 rubles.
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Rinzasip for children is a symptomatic remedy for the treatment of colds and acute respiratory diseases.
Release form and composition
Dosage form - granular powder for the preparation of a solution for oral administration: pink color of varying intensity with white and dark pink blotches, with raspberry flavor (3 g each in multilayer sachets, in a cardboard box 5 or 10 sachets and instructions for using Rinzasip for children) …
The composition of the preparation for 1 sachet:
- active substances: paracetamol - 280 mg, ascorbic acid - 100 mg, pheniramine maleate - 10 mg;
- auxiliary components: raspberry flavor Permasil 11036-31, sucrose, acesulfame potassium, aspartame, magnesium citrate, dye azorubin red.
Pharmacological properties
Pharmacodynamics
The action of the combined preparation Rinzasip for children is due to the properties of its active ingredients:
- paracetamol (non-narcotic analgesic) - antipyretic and analgesic agent that reduces fever and reduces pain associated with colds (headache, joint and muscle pain, sore throat);
- ascorbic acid (vitamin agent) - an antioxidant involved in the regulation of carbohydrate metabolism, redox processes and blood clotting, in the synthesis of steroid hormones and tissue regeneration; reduces vascular permeability, increases the body's resistance to the adverse effects of various environmental factors;
- pheniramine (a blocker of H1-histamine receptors) is an antiallergic agent that eliminates symptoms typical of colds, such as itching in the eyes, nose and throat, swelling and hyperemia of the nasal mucosa, paranasal sinuses and nasopharynx, exudative manifestations (lacrimation, rhinorrhea).
Pharmacokinetics
Paracetamol is absorbed quickly and almost completely from the gastrointestinal tract (GIT). The maximum plasma concentration (C max) is observed 10-60 minutes after taking the drug. The drug is distributed in most tissues of the body, including penetrates the placental barrier and into breast milk. When used in therapeutic doses, it binds to plasma proteins slightly, but the binding increases with increasing concentration. The primary metabolism of paracetamol occurs in the liver. It is excreted from the body mainly in the form of sulfates and glucuronides through the kidneys. The half-life (T 1/2) is 1–3 hours.
Ascorbic acid is completely and rapidly absorbed in the gastrointestinal tract. Plasma proteins bind 25%. It is excreted in the urine as metabolites. In case of taking excessive doses, it is excreted quickly unchanged.
Pheniramine C max reaches within 1–2.5 hours. About 70–80% of the dose is excreted unchanged or in the form of metabolites in the urine. T 1/2 is 16-19 hours.
Indications for use
Rinzasip for children is used to eliminate symptoms of colds, including influenza, acute respiratory diseases, as well as rhinitis and rhinopharyngitis of allergic or infectious-inflammatory etiology.
Contraindications
Absolute:
- age up to 6 years;
- period of pregnancy and lactation;
- glucose-galactose malabsorption;
- intolerance to fructose;
- deficiency of sucrase / isomaltase;
- phenylketonuria;
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- blood diseases;
- severe liver / kidney dysfunction;
- portal hypertension;
- alcoholism;
- hypersensitivity to any active or auxiliary component of the drug.
Relative (Rinzasip for children should be used with caution):
- congenital hyperbilirubinemia (Dubin-Johnson, Gilbert or Rotor syndromes);
- difficulty urinating;
- Chronical bronchitis;
- bronchial asthma;
- pyloroduodenal obstruction;
- stenosing ulcer of the stomach and / or duodenum;
- emphysema;
- diabetes;
- co-administration of tricyclic antidepressants or monoamine oxidase inhibitors (MAO);
- simultaneous use of drugs with a potential negative effect on the liver (carbamazepine, isoniazid, rifampicin, phenytoin, zidovudine, phenobarbital, barbiturates and other inducers of microsomal liver enzymes).
Rinzasip for children, instructions for use: method and dosage
A solution is prepared from Rinzasip granular powder for children: 1 sachet per glass (200 ml) of warm water. The drug is taken orally.
Recommended amount of sachets for children of different ages:
- 6-10 years old - 1 sachet 2 times a day;
- 10-12 years old - 1 sachet 3 times a day;
- 12-15 years old - 1 sachet 4 times a day.
The minimum acceptable interval between doses is 4 hours.
Treatment with the drug is carried out for no more than 5 days.
Side effects
When taking Rinzasip for children, the following adverse reactions may develop:
- from the digestive system: dryness of the oral mucosa, pain in the epigastric region, nausea, vomiting, hepatotoxic symptoms;
- from the urinary system: difficulty urinating, nephrotoxic manifestations (interstitial nephritis, glucosuria, renal colic, papillary necrosis);
- from the senses: paresis of accommodation, mydriasis, increased intraocular pressure;
- from the nervous system: sleep disturbance, drowsiness, headache, irritability, dizziness;
- on the part of the hematopoietic organs: agranulocytosis, thrombocytopenia, leukopenia, pancytopenia, methemoglobinemia, anemia (including aplastic and hemolytic);
- allergic reactions: urticaria and other skin rashes, itching of the skin, anaphylactic shock, angioedema;
- others: bronchospasm.
In very rare cases, while taking Rinzasip for children, the following serious skin reactions occur:
- Stevens-Johnson syndrome (malignant exudative erythema): a severe form of erythema multiforme, accompanied by the appearance of blisters on the skin and mucous membranes, including the eyes, mouth, throat and genitals;
- acute generalized exanthematous pustulosis: an acute condition manifested by fever, the appearance of a pustular rash, diffuse erythema with burning and itching, sometimes accompanied by swelling of the mucous membranes, face and hands;
- toxic epidermal necrolysis (Lyell's syndrome): severe allergic bullous dermatitis, which is a consequence of extensive death of epithelial tissue cells (keratinocytes) and leading to the detachment of large areas of the skin in places of the dermoepidermal junction (externally, the skin looks like they are scalded with boiling water).
Overdose
In case of an overdose of Rinzasip for children, you should urgently call a doctor. Prompt first aid is critical, even in the absence of any toxic symptoms.
Symptoms of a pheniramine overdose: impaired consciousness, convulsions, coma.
In children under 12 years of age, an acute overdose of paracetamol is possible if taken ≤ 0.15 g / kg, it is not associated with hepatotoxicity. In adolescents over 12 years old and adults, overdose symptoms occur within 8 hours after taking paracetamol at a dose of more than 7.5 g. Deaths are possible in the absence of medical care after taking a dose of 15 g or more, are rare (<3-4% of patients, who have not received appropriate treatment).
It should be borne in mind that the threshold of sensitivity to paracetamol can be reduced in children, as well as in some patients due to malnutrition, alcohol consumption or taking certain medications (for example, inducers of liver microsomal enzymes).
Symptoms that occur in the first 24 hours after taking an excessive dose of the drug: increased sweating, general malaise, pallor of the skin, abdominal pain, nausea, vomiting.
After 12–48–72 hours, signs of a functional liver disorder may develop: increased activity of liver enzymes, hepatonecrosis. With severe intoxication, liver failure, progressive encephalopathy, coma are possible. In rare cases, liver failure has a fulminant course and is complicated by renal failure (tubular necrosis).
It is expected that acute liver failure may lead to the following clinical disorders: bleeding from the gastrointestinal tract, pancreatitis, lactic acidosis, metabolic acidosis, hypoglycemia, respiratory failure, coagulopathy, disseminated intravascular coagulation, thrombocytopenia, bacterial / fungal infection, encephalitis, cerebral edema, arterial hypotension, cardiomyopathy, multiple organ failure, coma. The fulminant development of liver failure or its consequences can be fatal.
The patient is first washed out of the stomach. If no more than 6 hours have passed since taking the drug, the intake of activated carbon is indicated. After 8-9 hours donors of SH-groups and precursors of glutathione (methionine) synthesis are introduced, after 12 hours - acetylcysteine. Additional medical measures (the need for the subsequent administration of methionine and acetylcysteine) are determined individually after finding out the concentration of paracetamol in the blood, and also depending on the period after taking the drug. To eliminate the negative manifestations of an overdose, symptomatic therapy is performed.
special instructions
Rinzasip for children should not be taken together with other drugs that contain paracetamol.
During treatment with the drug, the peripheral blood parameters, the state of the kidneys and liver should be monitored.
The composition of Rinzasip powder for children includes sucrose: in 1 sachet - 2361.7 mg, which is equivalent to 0.2 bread units. This should be taken into account when treating children with diabetes mellitus and patients on a low-calorie diet.
People receiving paracetamol should not be tested for plasma glucose or uric acid, as the drug distorts the results.
If symptoms of the disease persist or worsen after 5 days of taking Rinzasip for children, you should consult a doctor.
Influence on the ability to drive vehicles and complex mechanisms
The drug can cause drowsiness, which should be taken into account when doing activities that require increased attention and speed of reactions.
Application during pregnancy and lactation
Clinical studies of the effect of the drug on the fetus / child when taken during pregnancy and lactation have not been conducted, therefore, Rinzasip for children is contraindicated for women to take during the indicated periods of life.
Pediatric use
Rinzasip for children is not intended for the treatment of patients under the age of 6 years.
With impaired renal function
Taking the drug is contraindicated in severe functional disorders of the kidneys.
For violations of liver function
Reception of Rinzasip for children is contraindicated in severe functional disorders of the liver.
Drug interactions
- uricosuric drugs: under the influence of paracetamol, their effect decreases;
- glucocorticosteroids: the risk of glaucoma increases;
- inhibitors of microsomal oxidation (for example, cimetidine): the likelihood of developing the hepatotoxic effect of paracetamol decreases;
- ethanol, inducers of microsomal liver enzymes (including isoniazid, carbamazepine, phenytoin, barbiturates, zidovudine, rifampicin): the hepatotoxic effect of paracetamol is enhanced;
- ethanol, sedatives, MAO inhibitors: their effect is enhanced;
- cardiac glycosides (including digoxin): arrhythmia may develop, the risk of myocardial infarction increases;
- indirect anticoagulants (warfarin and other coumarin derivatives): with occasional intake of paracetamol, the international normalized ratio does not change, however, with prolonged use, the effect of these drugs increases, the risk of bleeding increases;
- salicylates: the nephrotoxic effect is enhanced;
- chloramphenicol: its half-life increases;
- antipsychotics (phenothiazine derivatives), antiparkinsonian drugs, antidepressants: the sedative effect increases, there is a risk of dryness of the oral mucosa, urinary retention and constipation;
- other drugs with anticholinergic properties (atropine-like antispasmodic drugs, antipsychotics of the phenothiazine series, antihistamines): central atropine-like effects are enhanced.
Analogs
Rinzasip's analogues for children are Rinza for children, Antigrippin for children, DesGrippin, Fervex for children, etc.
Terms and conditions of storage
Store in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Rinzasip for children
Parents who used the drug to treat children leave mostly positive reviews about Rinzasip for children. They note that when taking the drug, unpleasant cold symptoms are effectively eliminated: headache, rhinorrhea, fever, nasal congestion. The action of the drug develops rapidly. The prepared solution has a raspberry flavor, which, however, not all children like. The powder is relatively inexpensive.
Of the shortcomings, they indicate the content of the dye, the presence of a large list of contraindications and possible side effects. In isolated cases, there are complaints about the lack of effect from taking Rinzasip for children.
Price for Rinzasip for children in pharmacies
The price of Rinzasip for children in the form of a powder for the preparation of a solution for oral administration is approximately 290–330 rubles. for a pack of 10 sachets.
Rinzasip for children: prices in online pharmacies
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Drug name Price Pharmacy |
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Rinzasip for children 280 mg + 10 mg + 100 mg powder for preparation of oral solution raspberry 3 g 10 pcs. 243 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
